| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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199 genes differentially expressed following the methotrexate-1957 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| ACAN | aggrecan |
| AMBRA1 | autophagy/beclin-1 regulator 1 |
| ANKRD12 | ankyrin repeat domain 12 |
| ARF3 | ADP-ribosylation factor 3 |
| B3GALT4 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 |
| C21ORF91 | chromosome 21 open reading frame 91 |
| CD2BP2 | CD2 (cytoplasmic tail) binding protein 2 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| CHD3 | chromodomain helicase DNA binding protein 3 |
| CIZ1 | CDKN1A interacting zinc finger protein 1 |
| CLIP2 | CAP-GLY domain containing linker protein 2 |
| CPA4 | carboxypeptidase A4 |
| CRTC1 | CREB regulated transcription coactivator 1 |
| CUEDC1 | CUE domain containing 1 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 |
| DXO | decapping exoribonuclease |
| EFNA3 | ephrin-A3 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 |
| ERN2 | endoplasmic reticulum to nucleus signaling 2 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
| EXOSC7 | exosome component 7 |
| FAM189A2 | family with sequence similarity 189, member A2 |
| FAM89B | family with sequence similarity 89, member B |
| FARSA | phenylalanyl-tRNA synthetase, alpha subunit |
| FSD1 | fibronectin type III and SPRY domain containing 1 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 |
| GJD2 | gap junction protein, delta 2, 36kDa |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide |
| HIST1H3G | histone cluster 1, H3g |
| HLA-G | major histocompatibility complex, class I, G |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) |
| HMOX2 | heme oxygenase 2 |
| HYAL3 | hyaluronoglucosaminidase 3 |
| KCTD2 | potassium channel tetramerization domain containing 2 |
| KDM4D | lysine (K)-specific demethylase 4D |
| KYNU | kynureninase |
| LY6G6C | lymphocyte antigen 6 complex, locus G6C |
| MAP2K5 | mitogen-activated protein kinase kinase 5 |
| MAPK10 | mitogen-activated protein kinase 10 |
| MAPK11 | mitogen-activated protein kinase 11 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 |
| MED12 | mediator complex subunit 12 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria |
| MTF1 | metal-regulatory transcription factor 1 |
| MVK | mevalonate kinase |
| MYO9B | myosin IXB |
| NCR2 | natural cytotoxicity triggering receptor 2 |
| NSUN5P1 | NOP2/Sun domain family, member 5 pseudogene 1 |
| NTHL1 | nth endonuclease III-like 1 (E. coli) |
| NTRK3 | neurotrophic tyrosine kinase, receptor, type 3 |
| NUDT3 | nudix (nucleoside diphosphate linked moiety X)-type motif 3 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa |
| PDE4DIP | phosphodiesterase 4D interacting protein |
| PECR | peroxisomal trans-2-enoyl-CoA reductase |
| PISD | phosphatidylserine decarboxylase |
| PLEKHO2 | pleckstrin homology domain containing, family O member 2 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit |
| POLR2F | polymerase (RNA) II (DNA directed) polypeptide F |
| PSMC2 | proteasome (prosome, macropain) 26S subunit, ATPase, 2 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) |
| PTK6 | protein tyrosine kinase 6 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) |
| PVR | poliovirus receptor |
| RAMP3 | receptor (G protein-coupled) activity modifying protein 3 |
| RBM47 | RNA binding motif protein 47 |
| RRBP1 | ribosome binding protein 1 |
| RUNX1 | runt-related transcription factor 1 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| SIGLEC15 | sialic acid binding Ig-like lectin 15 |
| SIRPA | signal-regulatory protein alpha |
| SLC38A7 | solute carrier family 38, member 7 |
| SLC7A6 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 |
| SMG5 | SMG5 nonsense mediated mRNA decay factor |
| SREBF1 | sterol regulatory element binding transcription factor 1 |
| SSX2IP | synovial sarcoma, X breakpoint 2 interacting protein |
| TES | testin LIM domain protein |
| TEX40 | testis expressed 40 |
| TLN2 | talin 2 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 |
| TMEM104 | transmembrane protein 104 |
| TMEM97 | transmembrane protein 97 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b |
| TRA2B | transformer 2 beta homolog (Drosophila) |
| TRIM29 | tripartite motif containing 29 |
| TSKU | tsukushi, small leucine rich proteoglycan |
| TTC3 | tetratricopeptide repeat domain 3 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 |
| UBTF | upstream binding transcription factor, RNA polymerase I |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) |
| WSCD1 | WSC domain containing 1 |
| ZKSCAN5 | zinc finger with KRAB and SCAN domains 5 |
| ZNF609 | zinc finger protein 609 |
| ZNF75D | zinc finger protein 75D |
| ZSCAN26 | zinc finger and SCAN domain containing 26 |
| Symbol | Name |
|---|---|
| ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 |
| ACADM | acyl-CoA dehydrogenase, C-4 to C-12 straight chain |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
| ACTL6A | actin-like 6A |
| ACTR6 | ARP6 actin-related protein 6 homolog (yeast) |
| AHR | aryl hydrocarbon receptor |
| APIP | APAF1 interacting protein |
| C12ORF29 | chromosome 12 open reading frame 29 |
| C1D | C1D nuclear receptor corepressor |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase |
| CDC42SE1 | CDC42 small effector 1 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 |
| CLASRP | CLK4-associating serine/arginine rich protein |
| CPOX | coproporphyrinogen oxidase |
| CRYBG3 | beta-gamma crystallin domain containing 3 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 |
| DCK | deoxycytidine kinase |
| DIP2A | DIP2 disco-interacting protein 2 homolog A (Drosophila) |
| DMTF1 | cyclin D binding myb-like transcription factor 1 |
| DMXL1 | Dmx-like 1 |
| DNAAF2 | dynein, axonemal, assembly factor 2 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 |
| DOCK1 | dedicator of cytokinesis 1 |
| DPYD | dihydropyrimidine dehydrogenase |
| EAPP | E2F-associated phosphoprotein |
| ERBB2IP | erbb2 interacting protein |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) |
| FAM50B | family with sequence similarity 50, member B |
| FBXO5 | F-box protein 5 |
| FGFBP1 | fibroblast growth factor binding protein 1 |
| FNBP1L | formin binding protein 1-like |
| GCLM | glutamate-cysteine ligase, modifier subunit |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GJA1 | gap junction protein, alpha 1, 43kDa |
| GTF2F2 | general transcription factor IIF, polypeptide 2, 30kDa |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 |
| HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 |
| ITGAV | integrin, alpha V |
| JRKL | JRK-like |
| KIAA0753 | KIAA0753 |
| KIAA1598 | |
| KLF10 | Kruppel-like factor 10 |
| KTN1 | kinectin 1 (kinesin receptor) |
| LACTB2 | lactamase, beta 2 |
| LGMN | legumain |
| LYPLA1 | lysophospholipase I |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MEX3C | mex-3 RNA binding family member C |
| MRPS15 | mitochondrial ribosomal protein S15 |
| NAP1L2 | nucleosome assembly protein 1-like 2 |
| NEMF | nuclear export mediator factor |
| NET1 | neuroepithelial cell transforming 1 |
| ORC6 | origin recognition complex, subunit 6 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 |
| PAQR3 | progestin and adipoQ receptor family member III |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 |
| PDCD10 | programmed cell death 10 |
| PIGK | phosphatidylinositol glycan anchor biosynthesis, class K |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) |
| PLA2G12A | phospholipase A2, group XIIA |
| POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) |
| PROCR | protein C receptor, endothelial |
| PVRL3 | poliovirus receptor-related 3 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 |
| SAR1B | secretion associated, Ras related GTPase 1B |
| SDCCAG3 | serologically defined colon cancer antigen 3 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 |
| SFMBT1 | Scm-like with four mbt domains 1 |
| SGMS1 | sphingomyelin synthase 1 |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 |
| SLMO2 | slowmo homolog 2 (Drosophila) |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 |
| SP3 | Sp3 transcription factor |
| SRBD1 | S1 RNA binding domain 1 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 |
| STXBP1 | syntaxin binding protein 1 |
| TAF1A | TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa |
| TBX3 | T-box 3 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) |
| THUMPD1 | THUMP domain containing 1 |
| TMEM106B | transmembrane protein 106B |
| TMEM165 | transmembrane protein 165 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit |
| TSPYL4 | TSPY-like 4 |
| TTC13 | tetratricopeptide repeat domain 13 |
| TVP23B | trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) |
| UBE2NL | ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) |
| UBXN2B | UBX domain protein 2B |
| VASP | vasodilator-stimulated phosphoprotein |
| ZNF143 | zinc finger protein 143 |
| ZNF239 | zinc finger protein 239 |
| ZNF652 | zinc finger protein 652 |
