| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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199 genes differentially expressed following the methotrexate-2041 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit |
| AP5Z1 | adaptor-related protein complex 5, zeta 1 subunit |
| APP | amyloid beta (A4) precursor protein |
| ARMT1 | acidic residue methyltransferase 1 |
| ATP11A | ATPase, class VI, type 11A |
| AZI2 | 5-azacytidine induced 2 |
| BLZF1 | basic leucine zipper nuclear factor 1 |
| BMP2K | BMP2 inducible kinase |
| C22ORF29 | chromosome 22 open reading frame 29 |
| CAST | calpastatin |
| CBY1 | chibby homolog 1 (Drosophila) |
| CHMP6 | charged multivesicular body protein 6 |
| CLCC1 | chloride channel CLIC-like 1 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 |
| CMC4 | C-x(9)-C motif containing 4 |
| CPOX | coproporphyrinogen oxidase |
| CR1 | complement component (3b/4b) receptor 1 (Knops blood group) |
| CTH | cystathionine gamma-lyase |
| CTSS | cathepsin S |
| CTTN | cortactin |
| CYB5A | cytochrome b5 type A (microsomal) |
| DHFR | dihydrofolate reductase |
| DHRS11 | dehydrogenase/reductase (SDR family) member 11 |
| EID1 | EP300 interacting inhibitor of differentiation 1 |
| EIF4E | eukaryotic translation initiation factor 4E |
| ELMO2 | engulfment and cell motility 2 |
| FAM114A2 | family with sequence similarity 114, member A2 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog |
| FRY | furry homolog (Drosophila) |
| GCFC2 | GC-rich sequence DNA-binding factor 2 |
| GLRX3 | glutaredoxin 3 |
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) |
| HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U-like 1 |
| HSF2 | heat shock transcription factor 2 |
| ITM2B | integral membrane protein 2B |
| IVNS1ABP | influenza virus NS1A binding protein |
| KANK1 | KN motif and ankyrin repeat domains 1 |
| KBTBD4 | kelch repeat and BTB (POZ) domain containing 4 |
| KLHL23 | kelch-like family member 23 |
| LAMP2 | lysosomal-associated membrane protein 2 |
| MAGOHB | mago-nashi homolog B (Drosophila) |
| MVK | mevalonate kinase |
| NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit |
| NAT6 | N-acetyltransferase 6 (GCN5-related) |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 |
| NUDT2 | nudix (nucleoside diphosphate linked moiety X)-type motif 2 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin |
| PAOX | polyamine oxidase (exo-N4-amino) |
| PCIF1 | PDX1 C-terminal inhibiting factor 1 |
| PGF | placental growth factor |
| PLAA | phospholipase A2-activating protein |
| PLS1 | plastin 1 |
| PMS2P3 | postmeiotic segregation increased 2 pseudogene 3 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 |
| RBBP5 | retinoblastoma binding protein 5 |
| RBM8A | RNA binding motif protein 8A |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 |
| RPS2 | ribosomal protein S2 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SDC2 | syndecan 2 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| SETD6 | SET domain containing 6 |
| SH2D2A | SH2 domain containing 2A |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 |
| SLMO2 | slowmo homolog 2 (Drosophila) |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
| SNAPC5 | small nuclear RNA activating complex, polypeptide 5, 19kDa |
| SRBD1 | S1 RNA binding domain 1 |
| SUMO1 | small ubiquitin-like modifier 1 |
| TBC1D4 | TBC1 domain family, member 4 |
| THTPA | thiamine triphosphatase |
| TLE2 | transducin-like enhancer of split 2 |
| TLN1 | talin 1 |
| TMED1 | transmembrane emp24 protein transport domain containing 1 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 |
| TPD52 | tumor protein D52 |
| TRABD | TraB domain containing |
| TRIM68 | tripartite motif containing 68 |
| TUBGCP2 | tubulin, gamma complex associated protein 2 |
| TWIST1 | twist family bHLH transcription factor 1 |
| UGDH | UDP-glucose 6-dehydrogenase |
| UNG | uracil-DNA glycosylase |
| URI1 | URI1, prefoldin-like chaperone |
| VAC14 | Vac14 homolog (S. cerevisiae) |
| WDR61 | WD repeat domain 61 |
| ZC4H2 | zinc finger, C4H2 domain containing |
| ZNF133 | zinc finger protein 133 |
| ZNF226 | zinc finger protein 226 |
| ZNF79 | zinc finger protein 79 |
| Symbol | Name |
|---|---|
| ABT1 | activator of basal transcription 1 |
| ARG1 | arginase 1 |
| ARMC6 | armadillo repeat containing 6 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
| ATAT1 | alpha tubulin acetyltransferase 1 |
| ATF3 | activating transcription factor 3 |
| AURKB | aurora kinase B |
| C9ORF40 | chromosome 9 open reading frame 40 |
| CCNB1 | cyclin B1 |
| CCNB2 | cyclin B2 |
| CCZ1 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) |
| CDC20 | cell division cycle 20 |
| CDCA3 | cell division cycle associated 3 |
| CENPE | centromere protein E, 312kDa |
| CHRNB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) |
| CHST4 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 |
| COG7 | component of oligomeric golgi complex 7 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) |
| CRYBB2P1 | crystallin, beta B2 pseudogene 1 |
| CSTF3 | cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa |
| DEPDC1 | DEP domain containing 1 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
| EGLN2 | egl-9 family hypoxia-inducible factor 2 |
| ELP4 | elongator acetyltransferase complex subunit 4 |
| EMC9 | ER membrane protein complex subunit 9 |
| FGF4 | fibroblast growth factor 4 |
| FOXM1 | forkhead box M1 |
| GPR21 | G protein-coupled receptor 21 |
| H1FX | H1 histone family, member X |
| HIST1H1C | histone cluster 1, H1c |
| HIST1H1E | histone cluster 1, H1e |
| HIST1H4C | histone cluster 1, H4c |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) |
| HSPA14 | heat shock 70kDa protein 14 |
| KIF11 | kinesin family member 11 |
| KIF14 | kinesin family member 14 |
| KIF20A | kinesin family member 20A |
| KIFC1 | kinesin family member C1 |
| KIZ | kizuna centrosomal protein |
| LONRF3 | LON peptidase N-terminal domain and ring finger 3 |
| MAPK10 | mitogen-activated protein kinase 10 |
| MELK | maternal embryonic leucine zipper kinase |
| METTL4 | methyltransferase like 4 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase |
| MICALL2 | MICAL-like 2 |
| MPDU1 | mannose-P-dolichol utilization defect 1 |
| MSL2 | male-specific lethal 2 homolog (Drosophila) |
| MTERF4 | mitochondrial transcription termination factor 4 |
| MTMR14 | myotubularin related protein 14 |
| MUC3A | mucin 3A, cell surface associated |
| NCAPD2 | non-SMC condensin I complex, subunit D2 |
| NCKAP1L | NCK-associated protein 1-like |
| NDC80 | NDC80 kinetochore complex component |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| NPPA | natriuretic peptide A |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit |
| PLEKHM2 | pleckstrin homology domain containing, family M (with RUN domain) member 2 |
| PLEKHO2 | pleckstrin homology domain containing, family O member 2 |
| PLK1 | polo-like kinase 1 |
| PMEL | premelanosome protein |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 |
| PVRL2 | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
| RAB3IL1 | RAB3A interacting protein (rabin3)-like 1 |
| RGP1 | RGP1 retrograde golgi transport homolog (S. cerevisiae) |
| RPL13P5 | ribosomal protein L13 pseudogene 5 |
| RPUSD2 | RNA pseudouridylate synthase domain containing 2 |
| RUFY2 | RUN and FYVE domain containing 2 |
| SAP30L | SAP30-like |
| SCN10A | sodium channel, voltage gated, type X alpha subunit |
| SKI | SKI proto-oncogene |
| SKIV2L2 | superkiller viralicidic activity 2-like 2 (S. cerevisiae) |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 |
| SLC39A1 | solute carrier family 39 (zinc transporter), member 1 |
| SLC5A5 | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
| SMG9 | SMG9 nonsense mediated mRNA decay factor |
| SPAG5 | sperm associated antigen 5 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TAC3 | tachykinin 3 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| TBC1D31 | TBC1 domain family, member 31 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 |
| TMPRSS6 | transmembrane protease, serine 6 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TPX2 | TPX2, microtubule-associated |
| TRPM2 | transient receptor potential cation channel, subfamily M, member 2 |
| TTC23 | tetratricopeptide repeat domain 23 |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| VILL | villin-like |
| WWC3 | WWC family member 3 |
| ZC3H4 | zinc finger CCCH-type containing 4 |
| ZNF804A | zinc finger protein 804A |
