| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
| Downloads & Tools |
197 genes differentially expressed following the methotrexate-5000 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase |
| ADAM22 | ADAM metallopeptidase domain 22 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) |
| ARVCF | armadillo repeat gene deleted in velocardiofacial syndrome |
| ASIC3 | acid sensing (proton gated) ion channel 3 |
| ATP11A | ATPase, class VI, type 11A |
| B3GALT4 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 |
| BTG2 | BTG family, member 2 |
| C8A | complement component 8, alpha polypeptide |
| CALHM2 | calcium homeostasis modulator 2 |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta |
| CCKAR | cholecystokinin A receptor |
| CD22 | CD22 molecule |
| CDKL1 | cyclin-dependent kinase-like 1 (CDC2-related kinase) |
| CEL | carboxyl ester lipase |
| CEMP1 | cementum protein 1 |
| CHKB | choline kinase beta |
| COL6A1 | collagen, type VI, alpha 1 |
| CPA2 | carboxypeptidase A2 (pancreatic) |
| CRYBB2P1 | crystallin, beta B2 pseudogene 1 |
| CUL7 | cullin 7 |
| DAGLA | diacylglycerol lipase, alpha |
| EED | embryonic ectoderm development |
| EGR1 | early growth response 1 |
| EPHB1 | EPH receptor B1 |
| FBXW4P1 | F-box and WD repeat domain containing 4 pseudogene 1 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa |
| FOXL1 | forkhead box L1 |
| FRMPD1 | FERM and PDZ domain containing 1 |
| FST | follistatin |
| FUT3 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) |
| GADD45A | growth arrest and DNA-damage-inducible, alpha |
| GEMIN8 | gem (nuclear organelle) associated protein 8 |
| GMPR | guanosine monophosphate reductase |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O |
| GPR3 | G protein-coupled receptor 3 |
| GRM1 | glutamate receptor, metabotropic 1 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 |
| HMGA1 | high mobility group AT-hook 1 |
| HSPB6 | heat shock protein, alpha-crystallin-related, B6 |
| HTR3A | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic |
| ICA1 | islet cell autoantigen 1, 69kDa |
| IFT27 | intraflagellar transport 27 |
| INHBA | inhibin, beta A |
| KCNH2 | potassium channel, voltage gated eag related subfamily H, member 2 |
| KIAA0141 | KIAA0141 |
| KIF5C | kinesin family member 5C |
| KLHL22 | kelch-like family member 22 |
| KRT33A | keratin 33A, type I |
| LIF | leukemia inhibitory factor |
| LOC100131510 | uncharacterized LOC100131510 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MAPK8 | mitogen-activated protein kinase 8 |
| MAST3 | microtubule associated serine/threonine kinase 3 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 |
| MEG3 | maternally expressed 3 (non-protein coding) |
| MMP3 | matrix metallopeptidase 3 |
| MNMIP1 | manchette microtubule inner protein 1 |
| MYBPC3 | myosin binding protein C, cardiac |
| MYL4 | myosin, light chain 4, alkali; atrial, embryonic |
| MYLK | myosin light chain kinase |
| NBR2 | neighbor of BRCA1 gene 2 (non-protein coding) |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase |
| NF1 | neurofibromin 1 |
| NOL12 | nucleolar protein 12 |
| NOX5 | NADPH oxidase, EF-hand calcium binding domain 5 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 |
| POU5F1B | POU class 5 homeobox 1B |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit |
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 |
| RAB6A | RAB6A, member RAS oncogene family |
| RND1 | Rho family GTPase 1 |
| SIGLEC8 | sialic acid binding Ig-like lectin 8 |
| SIRT5 | sirtuin 5 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 |
| TM2D1 | TM2 domain containing 1 |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TMEM63A | transmembrane protein 63A |
| TNFSF18 | tumor necrosis factor (ligand) superfamily, member 18 |
| TRA | T cell receptor alpha locus |
| TRAF3IP3 | TRAF3 interacting protein 3 |
| TREX1 | three prime repair exonuclease 1 |
| TRIM31 | tripartite motif containing 31 |
| TTC9 | tetratricopeptide repeat domain 9 |
| UBOX5 | U-box domain containing 5 |
| VAC14 | Vac14 homolog (S. cerevisiae) |
| VASH2 | vasohibin 2 |
| VIM | vimentin |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) |
| WNT16 | wingless-type MMTV integration site family, member 16 |
| WSCD1 | WSC domain containing 1 |
| ZEB1 | zinc finger E-box binding homeobox 1 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 |
| ZNF37BP | zinc finger protein 37B, pseudogene |
| ZNF484 | zinc finger protein 484 |
| Symbol | Name |
|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 |
| AP1AR | adaptor-related protein complex 1 associated regulatory protein |
| ARHGAP11A | Rho GTPase activating protein 11A |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
| AURKA | aurora kinase A |
| BORA | bora, aurora kinase A activator |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B |
| C1ORF109 | chromosome 1 open reading frame 109 |
| CAPN15 | calpain 15 |
| CCDC121 | coiled-coil domain containing 121 |
| CCNB1 | cyclin B1 |
| CDC20 | cell division cycle 20 |
| CDCA3 | cell division cycle associated 3 |
| CDCA8 | cell division cycle associated 8 |
| CDK3 | cyclin-dependent kinase 3 |
| CENPE | centromere protein E, 312kDa |
| CENPF | centromere protein F, 350/400kDa |
| CEP85 | centrosomal protein 85kDa |
| CHST10 | carbohydrate sulfotransferase 10 |
| CKAP2 | cytoskeleton associated protein 2 |
| CLEC16A | C-type lectin domain family 16, member A |
| COBL | cordon-bleu WH2 repeat protein |
| CPTP | ceramide-1-phosphate transfer protein |
| DBF4 | DBF4 zinc finger |
| DENND1B | DENN/MADD domain containing 1B |
| DEPDC1 | DEP domain containing 1 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
| ECT2 | epithelial cell transforming 2 |
| EFNA3 | ephrin-A3 |
| EGLN2 | egl-9 family hypoxia-inducible factor 2 |
| ELOVL4 | ELOVL fatty acid elongase 4 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 |
| EXOC5 | exocyst complex component 5 |
| FAM64A | family with sequence similarity 64, member A |
| FUZ | fuzzy planar cell polarity protein |
| GINS4 | GINS complex subunit 4 (Sld5 homolog) |
| GPSM2 | G-protein signaling modulator 2 |
| H1F0 | H1 histone family, member 0 |
| HIST1H1E | histone cluster 1, H1e |
| HIST1H4C | histone cluster 1, H4c |
| HJURP | Holliday junction recognition protein |
| HMHA1 | histocompatibility (minor) HA-1 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) |
| IDI2-AS1 | IDI2 antisense RNA 1 |
| IP6K2 | inositol hexakisphosphate kinase 2 |
| KIF11 | kinesin family member 11 |
| KIF14 | kinesin family member 14 |
| KIF18A | kinesin family member 18A |
| KIF20A | kinesin family member 20A |
| KIF23 | kinesin family member 23 |
| LIG4 | ligase IV, DNA, ATP-dependent |
| LMNB1 | lamin B1 |
| LRRC20 | leucine rich repeat containing 20 |
| MEIS1 | Meis homeobox 1 |
| METTL4 | methyltransferase like 4 |
| NDC80 | NDC80 kinetochore complex component |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit |
| PGP | phosphoglycolate phosphatase |
| PGPEP1 | pyroglutamyl-peptidase I |
| PLK1 | polo-like kinase 1 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 |
| PRC1 | protein regulator of cytokinesis 1 |
| PRR11 | proline rich 11 |
| PSRC1 | proline/serine-rich coiled-coil 1 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 |
| RCOR3 | REST corepressor 3 |
| RPL23AP32 | ribosomal protein L23a pseudogene 32 |
| SETD8 | SET domain containing (lysine methyltransferase) 8 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 |
| SMEK2 | SMEK homolog 2, suppressor of mek1 (Dictyostelium) |
| SNHG3 | small nucleolar RNA host gene 3 |
| SPDL1 | spindle apparatus coiled-coil protein 1 |
| SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 |
| STIL | SCL/TAL1 interrupting locus |
| SUV39H2 | suppressor of variegation 3-9 homolog 2 (Drosophila) |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| TDRD1 | tudor domain containing 1 |
| TET3 | tet methylcytosine dioxygenase 3 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TPST2 | tyrosylprotein sulfotransferase 2 |
| TPX2 | TPX2, microtubule-associated |
| TROAP | trophinin associated protein |
| TTK | TTK protein kinase |
| TXNIP | thioredoxin interacting protein |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| VCPIP1 | valosin containing protein (p97)/p47 complex interacting protein 1 |
| XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3 |
| ZC3H3 | zinc finger CCCH-type containing 3 |
| ZCCHC2 | zinc finger, CCHC domain containing 2 |
| ZMYM3 | zinc finger, MYM-type 3 |
| ZNF165 | zinc finger protein 165 |
| ZNF23 | zinc finger protein 23 |
| ZNF468 | zinc finger protein 468 |
| ZNF652 | zinc finger protein 652 |
| ZNF668 | zinc finger protein 668 |
| ZNF675 | zinc finger protein 675 |
