| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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196 genes differentially expressed following the methotrexate-5419 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| A1CF | APOBEC1 complementation factor |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 |
| AREG | amphiregulin |
| ARID1A | AT rich interactive domain 1A (SWI-like) |
| ARNT | aryl hydrocarbon receptor nuclear translocator |
| ATF3 | activating transcription factor 3 |
| ATN1 | atrophin 1 |
| BHLHE40 | basic helix-loop-helix family, member e40 |
| BTG2 | BTG family, member 2 |
| CCDC64 | coiled-coil domain containing 64 |
| CCDC70 | coiled-coil domain containing 70 |
| CCL2 | chemokine (C-C motif) ligand 2 |
| CD44 | CD44 molecule (Indian blood group) |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CLDN17 | claudin 17 |
| CLMN | calmin (calponin-like, transmembrane) |
| CNTN1 | contactin 1 |
| COL14A1 | collagen, type XIV, alpha 1 |
| COL5A1 | collagen, type V, alpha 1 |
| CTC1 | CTS telomere maintenance complex component 1 |
| CTGF | connective tissue growth factor |
| CYR61 | cysteine-rich, angiogenic inducer, 61 |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DEPTOR | DEP domain containing MTOR-interacting protein |
| DFNB31 | deafness, autosomal recessive 31 |
| DTNA | dystrobrevin, alpha |
| DUSP4 | dual specificity phosphatase 4 |
| EED | embryonic ectoderm development |
| EGR1 | early growth response 1 |
| EGR3 | early growth response 3 |
| EVA1B | eva-1 homolog B (C. elegans) |
| FAS | Fas cell surface death receptor |
| FAXDC2 | fatty acid hydroxylase domain containing 2 |
| FBXL7 | F-box and leucine-rich repeat protein 7 |
| FBXL8 | F-box and leucine-rich repeat protein 8 |
| FBXO41 | F-box protein 41 |
| FSCN1 | fascin actin-bundling protein 1 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) |
| GADD45A | growth arrest and DNA-damage-inducible, alpha |
| GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 |
| GPR87 | G protein-coupled receptor 87 |
| GRM1 | glutamate receptor, metabotropic 1 |
| HBEGF | heparin-binding EGF-like growth factor |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 |
| JUN | jun proto-oncogene |
| KCNK12 | potassium channel, two pore domain subfamily K, member 12 |
| KCTD7 | potassium channel tetramerization domain containing 7 |
| KIAA1107 | KIAA1107 |
| KRT16 | keratin 16, type I |
| LAMC2 | laminin, gamma 2 |
| LIF | leukemia inhibitory factor |
| LMX1B | LIM homeobox transcription factor 1, beta |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 |
| MBD4 | methyl-CpG binding domain protein 4 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
| MED6 | mediator complex subunit 6 |
| METTL3 | methyltransferase like 3 |
| MLN | motilin |
| MR1 | major histocompatibility complex, class I-related |
| MST1 | macrophage stimulating 1 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog |
| NACA | nascent polypeptide-associated complex alpha subunit |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
| NOX5 | NADPH oxidase, EF-hand calcium binding domain 5 |
| NRP1 | neuropilin 1 |
| NRP2 | neuropilin 2 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| PARVA | parvin, alpha |
| PCDHGA1 | protocadherin gamma subfamily A, 1 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) |
| PLAU | plasminogen activator, urokinase |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 |
| PLXNB3 | plexin B3 |
| PNMAL1 | paraneoplastic Ma antigen family-like 1 |
| PON1 | paraoxonase 1 |
| POU4F1 | POU class 4 homeobox 1 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) |
| RAD23B | RAD23 homolog B (S. cerevisiae) |
| RASGRF1 | Ras protein-specific guanine nucleotide-releasing factor 1 |
| RIMS3 | regulating synaptic membrane exocytosis 3 |
| RPL35A | ribosomal protein L35a |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SESN1 | sestrin 1 |
| SIRT5 | sirtuin 5 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
| STK3 | serine/threonine kinase 3 |
| TAP2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
| TCF7L1 | transcription factor 7-like 1 (T-cell specific, HMG-box) |
| TCP10 | t-complex 10 |
| TNFRSF17 | tumor necrosis factor receptor superfamily, member 17 |
| TREX1 | three prime repair exonuclease 1 |
| ULBP2 | UL16 binding protein 2 |
| UPK2 | uroplakin 2 |
| WSB1 | WD repeat and SOCS box containing 1 |
| ZNF76 | zinc finger protein 76 |
| Symbol | Name |
|---|---|
| ACSL4 | acyl-CoA synthetase long-chain family member 4 |
| ACTL8 | actin-like 8 |
| AKAP12 | A kinase (PRKA) anchor protein 12 |
| AKIRIN1 | akirin 1 |
| ARMC7 | armadillo repeat containing 7 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
| BCL11B | B-cell CLL/lymphoma 11B (zinc finger protein) |
| BMP4 | bone morphogenetic protein 4 |
| C1ORF159 | chromosome 1 open reading frame 159 |
| C9ORF40 | chromosome 9 open reading frame 40 |
| CARD8 | caspase recruitment domain family, member 8 |
| CCNB1 | cyclin B1 |
| CCNF | cyclin F |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) |
| CDC20 | cell division cycle 20 |
| CDCA8 | cell division cycle associated 8 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 |
| CENPE | centromere protein E, 312kDa |
| CKS2 | CDC28 protein kinase regulatory subunit 2 |
| CNNM4 | cyclin and CBS domain divalent metal cation transport mediator 4 |
| CXADR | coxsackie virus and adenovirus receptor |
| DCUN1D2 | DCN1, defective in cullin neddylation 1, domain containing 2 |
| DEPDC1 | DEP domain containing 1 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
| DUSP2 | dual specificity phosphatase 2 |
| DZANK1 | double zinc ribbon and ankyrin repeat domains 1 |
| EGLN2 | egl-9 family hypoxia-inducible factor 2 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 |
| EHD3 | EH-domain containing 3 |
| EPHB3 | EPH receptor B3 |
| ERN2 | endoplasmic reticulum to nucleus signaling 2 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) |
| FAM204A | family with sequence similarity 204, member A |
| FAM64A | family with sequence similarity 64, member A |
| FRS2 | fibroblast growth factor receptor substrate 2 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) |
| GIT1 | G protein-coupled receptor kinase interacting ArfGAP 1 |
| GPR19 | G protein-coupled receptor 19 |
| GRTP1 | growth hormone regulated TBC protein 1 |
| H1F0 | H1 histone family, member 0 |
| HIST1H4C | histone cluster 1, H4c |
| HIST2H2AA3 | histone cluster 2, H2aa3 |
| HJURP | Holliday junction recognition protein |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) |
| HOXC5 | homeobox C5 |
| HSPA2 | heat shock 70kDa protein 2 |
| IDI2-AS1 | IDI2 antisense RNA 1 |
| IFI27 | interferon, alpha-inducible protein 27 |
| IP6K2 | inositol hexakisphosphate kinase 2 |
| KIF14 | kinesin family member 14 |
| KIF20A | kinesin family member 20A |
| KIF23 | kinesin family member 23 |
| KIFC1 | kinesin family member C1 |
| LBR | lamin B receptor |
| MATK | megakaryocyte-associated tyrosine kinase |
| MID1IP1 | MID1 interacting protein 1 |
| MKI67 | marker of proliferation Ki-67 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit |
| PELP1 | proline, glutamate and leucine rich protein 1 |
| PLEKHO1 | pleckstrin homology domain containing, family O member 1 |
| PLK1 | polo-like kinase 1 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 |
| PSRC1 | proline/serine-rich coiled-coil 1 |
| PTTG3P | pituitary tumor-transforming 3, pseudogene |
| PVRL3 | poliovirus receptor-related 3 |
| RAB3IL1 | RAB3A interacting protein (rabin3)-like 1 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 |
| REEP4 | receptor accessory protein 4 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) |
| RNASEL | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) |
| RPL23AP32 | ribosomal protein L23a pseudogene 32 |
| SAYSD1 | SAYSVFN motif domain containing 1 |
| SCAI | suppressor of cancer cell invasion |
| SETD8 | SET domain containing (lysine methyltransferase) 8 |
| SLC12A5 | solute carrier family 12 (potassium/chloride transporter), member 5 |
| SMTN | smoothelin |
| SPRY2 | sprouty homolog 2 (Drosophila) |
| SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 |
| SYNGR3 | synaptogyrin 3 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 |
| TBC1D17 | TBC1 domain family, member 17 |
| TMEM121 | transmembrane protein 121 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TPX2 | TPX2, microtubule-associated |
| TROAP | trophinin associated protein |
| TUBA3C | tubulin, alpha 3c |
| TXNIP | thioredoxin interacting protein |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| URGCP | upregulator of cell proliferation |
| VASH2 | vasohibin 2 |
| VGF | VGF nerve growth factor inducible |
| WDR25 | WD repeat domain 25 |
| ZC3H3 | zinc finger CCCH-type containing 3 |
| ZMYM1 | zinc finger, MYM-type 1 |
| ZNF165 | zinc finger protein 165 |
| ZNF492 | zinc finger protein 492 |
