| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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199 genes differentially expressed following the methotrexate-6318 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| ALG12 | ALG12, alpha-1,6-mannosyltransferase |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 |
| ATAT1 | alpha tubulin acetyltransferase 1 |
| ATXN2L | ataxin 2-like |
| C14ORF105 | chromosome 14 open reading frame 105 |
| C17ORF59 | chromosome 17 open reading frame 59 |
| C5ORF45 | chromosome 5 open reading frame 45 |
| CALD1 | caldesmon 1 |
| CCDC85B | coiled-coil domain containing 85B |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| CFAP69 | cilia and flagella associated protein 69 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 |
| CPEB1 | cytoplasmic polyadenylation element binding protein 1 |
| CPN2 | carboxypeptidase N, polypeptide 2 |
| CREB1 | cAMP responsive element binding protein 1 |
| CRELD1 | cysteine-rich with EGF-like domains 1 |
| CRTC1 | CREB regulated transcription coactivator 1 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| CYP2D6 | cytochrome P450, family 2, subfamily D, polypeptide 6 |
| DDIT3 | DNA-damage-inducible transcript 3 |
| DGCR11 | DiGeorge syndrome critical region gene 11 (non-protein coding) |
| DGCR9 | DiGeorge syndrome critical region gene 9 (non-protein coding) |
| DMTN | dematin actin binding protein |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 |
| DNAL4 | dynein, axonemal, light chain 4 |
| EHF | ets homologous factor |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) |
| EPS8L1 | EPS8-like 1 |
| ETNK2 | ethanolamine kinase 2 |
| FAM131B | family with sequence similarity 131, member B |
| FASTKD2 | FAST kinase domains 2 |
| FBXL15 | F-box and leucine-rich repeat protein 15 |
| FBXO31 | F-box protein 31 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 |
| GMPR | guanosine monophosphate reductase |
| GPR17 | G protein-coupled receptor 17 |
| GRIK2 | glutamate receptor, ionotropic, kainate 2 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 |
| HFE | hemochromatosis |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 |
| HMOX1 | heme oxygenase 1 |
| HOXC11 | homeobox C11 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon |
| IL11 | interleukin 11 |
| IRF4 | interferon regulatory factor 4 |
| IRX4 | iroquois homeobox 4 |
| ITGB4 | integrin, beta 4 |
| ITGB7 | integrin, beta 7 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 |
| KCNJ4 | potassium channel, inwardly rectifying subfamily J, member 4 |
| KCNS3 | potassium voltage-gated channel, modifier subfamily S, member 3 |
| KDM4C | lysine (K)-specific demethylase 4C |
| KLF13 | Kruppel-like factor 13 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
| LAMP1 | lysosomal-associated membrane protein 1 |
| MON1B | MON1 secretory trafficking family member B |
| MPI | mannose phosphate isomerase |
| MUC1 | mucin 1, cell surface associated |
| MXD3 | MAX dimerization protein 3 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
| NEURL1 | neuralized E3 ubiquitin protein ligase 1 |
| OAZ3 | ornithine decarboxylase antizyme 3 |
| OLFML2B | olfactomedin-like 2B |
| OVGP1 | oviductal glycoprotein 1, 120kDa |
| OXLD1 | oxidoreductase-like domain containing 1 |
| P2RY4 | pyrimidinergic receptor P2Y, G-protein coupled, 4 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| PDE8B | phosphodiesterase 8B |
| PDIA4 | protein disulfide isomerase family A, member 4 |
| PHLDB1 | pleckstrin homology-like domain, family B, member 1 |
| PLCD1 | phospholipase C, delta 1 |
| PLCG1 | phospholipase C, gamma 1 |
| PLXNC1 | plexin C1 |
| PPFIA3 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 |
| PRKCI | protein kinase C, iota |
| PTCRA | pre T-cell antigen receptor alpha |
| PTGER1 | prostaglandin E receptor 1 (subtype EP1), 42kDa |
| PTK6 | protein tyrosine kinase 6 |
| RARG | retinoic acid receptor, gamma |
| RHPN1-AS1 | RHPN1 antisense RNA 1 (head to head) |
| ROM1 | retinal outer segment membrane protein 1 |
| RWDD2A | RWD domain containing 2A |
| SDF2L1 | stromal cell-derived factor 2-like 1 |
| SIX3 | SIX homeobox 3 |
| SLC35C1 | solute carrier family 35 (GDP-fucose transporter), member C1 |
| SSH3 | slingshot protein phosphatase 3 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 |
| STOM | stomatin |
| TLR2 | toll-like receptor 2 |
| TMEM209 | transmembrane protein 209 |
| TMEM50B | transmembrane protein 50B |
| TMEM8A | transmembrane protein 8A |
| TMEM8B | transmembrane protein 8B |
| TMSB15A | thymosin beta 15a |
| TRIB3 | tribbles pseudokinase 3 |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) |
| Symbol | Name |
|---|---|
| AATF | apoptosis antagonizing transcription factor |
| ACAD10 | acyl-CoA dehydrogenase family, member 10 |
| ANKRD27 | ankyrin repeat domain 27 (VPS9 domain) |
| ATAD5 | ATPase family, AAA domain containing 5 |
| ATG16L1 | autophagy related 16-like 1 (S. cerevisiae) |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 |
| BATF3 | basic leucine zipper transcription factor, ATF-like 3 |
| CDCA8 | cell division cycle associated 8 |
| CENPA | centromere protein A |
| CHST10 | carbohydrate sulfotransferase 10 |
| CNKSR1 | connector enhancer of kinase suppressor of Ras 1 |
| CNTNAP3B | contactin associated protein-like 3B |
| CRYBA2 | crystallin, beta A2 |
| CRYBB2P1 | crystallin, beta B2 pseudogene 1 |
| CSRNP3 | cysteine-serine-rich nuclear protein 3 |
| DBF4 | DBF4 zinc finger |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
| DEPDC1 | DEP domain containing 1 |
| DSPP | dentin sialophosphoprotein |
| EGF | epidermal growth factor |
| ENTPD3 | ectonucleoside triphosphate diphosphohydrolase 3 |
| ERN2 | endoplasmic reticulum to nucleus signaling 2 |
| EVPL | envoplakin |
| FA2H | fatty acid 2-hydroxylase |
| FAM120C | family with sequence similarity 120C |
| FANCC | Fanconi anemia, complementation group C |
| FCHSD2 | FCH and double SH3 domains 2 |
| FEM1C | fem-1 homolog c (C. elegans) |
| FOXN2 | forkhead box N2 |
| FSD1 | fibronectin type III and SPRY domain containing 1 |
| GAL3ST4 | galactose-3-O-sulfotransferase 4 |
| GJC1 | gap junction protein, gamma 1, 45kDa |
| GTF3C4 | general transcription factor IIIC, polypeptide 4, 90kDa |
| HIST1H1E | histone cluster 1, H1e |
| HIST1H4C | histone cluster 1, H4c |
| HJURP | Holliday junction recognition protein |
| HLX | H2.0-like homeobox |
| HYMAI | hydatidiform mole associated and imprinted (non-protein coding) |
| IFT22 | intraflagellar transport 22 |
| IL17RA | interleukin 17 receptor A |
| JMJD4 | jumonji domain containing 4 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 |
| KIF20A | kinesin family member 20A |
| KIRREL | kin of IRRE like (Drosophila) |
| LHX6 | LIM homeobox 6 |
| LOC100286895 | cell division cycle 27 homolog pseudogene |
| LRP3 | low density lipoprotein receptor-related protein 3 |
| MAP3K12 | mitogen-activated protein kinase kinase kinase 12 |
| MCM9 | minichromosome maintenance complex component 9 |
| MN1 | meningioma (disrupted in balanced translocation) 1 |
| NDC80 | NDC80 kinetochore complex component |
| NDE1 | nudE neurodevelopment protein 1 |
| NFIL3 | nuclear factor, interleukin 3 regulated |
| NLGN1 | neuroligin 1 |
| NMRK1 | nicotinamide riboside kinase 1 |
| ONECUT2 | one cut homeobox 2 |
| OR7E156P | olfactory receptor, family 7, subfamily E, member 156 pseudogene |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) |
| PALMD | palmdelphin |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit |
| PCOLCE | procollagen C-endopeptidase enhancer |
| PDLIM2 | PDZ and LIM domain 2 (mystique) |
| PHC1 | polyhomeotic homolog 1 (Drosophila) |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma |
| PLEKHO2 | pleckstrin homology domain containing, family O member 2 |
| PLK1 | polo-like kinase 1 |
| POU2F1 | POU class 2 homeobox 1 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 |
| PRKCD | protein kinase C, delta |
| PRMT7 | protein arginine methyltransferase 7 |
| PSRC1 | proline/serine-rich coiled-coil 1 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 |
| RGS17 | regulator of G-protein signaling 17 |
| SCUBE3 | signal peptide, CUB domain, EGF-like 3 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) |
| SMG9 | SMG9 nonsense mediated mRNA decay factor |
| SND1-IT1 | SND1 intronic transcript 1 |
| SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 |
| STAG3L4 | stromal antigen 3-like 4 (pseudogene) |
| SULT1B1 | sulfotransferase family, cytosolic, 1B, member 1 |
| SYTL2 | synaptotagmin-like 2 |
| TICAM1 | toll-like receptor adaptor molecule 1 |
| TIMM50 | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 |
| TSKU | tsukushi, small leucine rich proteoglycan |
| TULP4 | tubby like protein 4 |
| TXNIP | thioredoxin interacting protein |
| UBQLN4 | ubiquilin 4 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 |
| USB1 | U6 snRNA biogenesis 1 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing |
| ZBTB39 | zinc finger and BTB domain containing 39 |
| ZFP36 | ZFP36 ring finger protein |
| ZNF254 | zinc finger protein 254 |
| ZNF304 | zinc finger protein 304 |
| ZNF385D | zinc finger protein 385D |
| ZNF552 | zinc finger protein 552 |
| ZNRD1-AS1 | ZNRD1 antisense RNA 1 |
