| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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192 genes differentially expressed following the methotrexate-6654 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| AGTR1 | angiotensin II receptor, type 1 |
| AKAP13 | A kinase (PRKA) anchor protein 13 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| ANK2 | ankyrin 2, neuronal |
| ARHGAP28 | Rho GTPase activating protein 28 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 |
| AVPR1A | arginine vasopressin receptor 1A |
| BAIAP3 | BAI1-associated protein 3 |
| BCL2L10 | BCL2-like 10 (apoptosis facilitator) |
| BMP8A | bone morphogenetic protein 8a |
| BTG2 | BTG family, member 2 |
| CCDC181 | coiled-coil domain containing 181 |
| CCDC82 | coiled-coil domain containing 82 |
| CCR7 | chemokine (C-C motif) receptor 7 |
| CDC14B | cell division cycle 14B |
| CFLAR | CASP8 and FADD-like apoptosis regulator |
| CHAT | choline O-acetyltransferase |
| CLEC4A | C-type lectin domain family 4, member A |
| CNTNAP2 | contactin associated protein-like 2 |
| DCHS2 | dachsous cadherin-related 2 |
| DEFB4A | defensin, beta 4A |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 |
| EDN3 | endothelin 3 |
| EED | embryonic ectoderm development |
| EML2 | echinoderm microtubule associated protein like 2 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) |
| ERMAP | erythroblast membrane-associated protein (Scianna blood group) |
| EZH1 | enhancer of zeste 1 polycomb repressive complex 2 subunit |
| FAM134B | family with sequence similarity 134, member B |
| FCER2 | Fc fragment of IgE, low affinity II, receptor for (CD23) |
| FGB | fibrinogen beta chain |
| FOXO4 | forkhead box O4 |
| GAB1 | GRB2-associated binding protein 1 |
| GREB1L | growth regulation by estrogen in breast cancer-like |
| GZMK | granzyme K (granzyme 3; tryptase II) |
| HEMK1 | HemK methyltransferase family member 1 |
| HOXC5 | homeobox C5 |
| HS3ST2 | heparan sulfate (glucosamine) 3-O-sulfotransferase 2 |
| HTR1F | 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled |
| ICAM5 | intercellular adhesion molecule 5, telencephalin |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial |
| INPP5J | inositol polyphosphate-5-phosphatase J |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| JPH3 | junctophilin 3 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like |
| KCNAB1 | potassium channel, voltage gated subfamily A regulatory beta subunit 1 |
| KCNJ5 | potassium channel, inwardly rectifying subfamily J, member 5 |
| KIR2DL5A | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A |
| KLF13 | Kruppel-like factor 13 |
| KMT2A | lysine (K)-specific methyltransferase 2A |
| LAMA4 | laminin, alpha 4 |
| LMX1B | LIM homeobox transcription factor 1, beta |
| LPA | lipoprotein, Lp(a) |
| LRRK1 | leucine-rich repeat kinase 1 |
| LSP1 | lymphocyte-specific protein 1 |
| MAGEC3 | melanoma antigen family C3 |
| MEP1B | meprin A, beta |
| MTMR7 | myotubularin related protein 7 |
| NPAS1 | neuronal PAS domain protein 1 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa |
| OLFM1 | olfactomedin 1 |
| OPRL1 | opiate receptor-like 1 |
| PAOX | polyamine oxidase (exo-N4-amino) |
| PASK | PAS domain containing serine/threonine kinase |
| PDCD6 | programmed cell death 6 |
| PDE4B | phosphodiesterase 4B, cAMP-specific |
| PDE4DIP | phosphodiesterase 4D interacting protein |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
| PMEL | premelanosome protein |
| PTGER1 | prostaglandin E receptor 1 (subtype EP1), 42kDa |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 |
| RAB36 | RAB36, member RAS oncogene family |
| RASA3 | RAS p21 protein activator 3 |
| RASAL2 | RAS protein activator like 2 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B |
| RHO | rhodopsin |
| RRN3P1 | RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1 |
| RS1 | retinoschisin 1 |
| RUNX1 | runt-related transcription factor 1 |
| SCN2A | sodium channel, voltage gated, type II alpha subunit |
| SCUBE3 | signal peptide, CUB domain, EGF-like 3 |
| SERHL2 | serine hydrolase-like 2 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) |
| SH2D3A | SH2 domain containing 3A |
| SH2D3C | SH2 domain containing 3C |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 |
| SLC34A2 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) |
| SPRYD7 | SPRY domain containing 7 |
| SRP72 | signal recognition particle 72kDa |
| TOX | thymocyte selection-associated high mobility group box |
| TTLL4 | tubulin tyrosine ligase-like family member 4 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) |
| VPS16 | vacuolar protein sorting 16 homolog (S. cerevisiae) |
| WSB1 | WD repeat and SOCS box containing 1 |
| ZZEF1 | zinc finger, ZZ-type with EF-hand domain 1 |
| Symbol | Name |
|---|---|
| ADAM23 | ADAM metallopeptidase domain 23 |
| AFAP1 | actin filament associated protein 1 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) |
| ALPK1 | alpha-kinase 1 |
| ANXA2P1 | annexin A2 pseudogene 1 |
| AOC2 | amine oxidase, copper containing 2 (retina-specific) |
| APOLD1 | apolipoprotein L domain containing 1 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 |
| ATAD5 | ATPase family, AAA domain containing 5 |
| ATG16L1 | autophagy related 16-like 1 (S. cerevisiae) |
| BAK1 | BCL2-antagonist/killer 1 |
| C10ORF88 | chromosome 10 open reading frame 88 |
| C14ORF105 | chromosome 14 open reading frame 105 |
| C5ORF42 | chromosome 5 open reading frame 42 |
| C9ORF9 | chromosome 9 open reading frame 9 |
| CD82 | CD82 molecule |
| CDCA8 | cell division cycle associated 8 |
| CLDN14 | claudin 14 |
| CLEC16A | C-type lectin domain family 16, member A |
| CRYGC | crystallin, gamma C |
| DEPDC1 | DEP domain containing 1 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 |
| DLK2 | delta-like 2 homolog (Drosophila) |
| DTX2 | deltex 2, E3 ubiquitin ligase |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 |
| ERN2 | endoplasmic reticulum to nucleus signaling 2 |
| FA2H | fatty acid 2-hydroxylase |
| FAT4 | FAT atypical cadherin 4 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
| FKBP10 | FK506 binding protein 10, 65 kDa |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) |
| GALK1 | galactokinase 1 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) |
| GLS2 | glutaminase 2 (liver, mitochondrial) |
| GLTSCR1 | glioma tumor suppressor candidate region gene 1 |
| GPC3 | glypican 3 |
| GPR39 | G protein-coupled receptor 39 |
| GTF3C5 | general transcription factor IIIC, polypeptide 5, 63kDa |
| H2AFJ | H2A histone family, member J |
| HDAC11 | histone deacetylase 11 |
| HIST1H1D | histone cluster 1, H1d |
| HIST1H2AJ | histone cluster 1, H2aj |
| HIST1H2AK | histone cluster 1, H2ak |
| HIST1H2BN | histone cluster 1, H2bn |
| HOXC8 | homeobox C8 |
| HSF2BP | heat shock transcription factor 2 binding protein |
| IFI44L | interferon-induced protein 44-like |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 |
| KRT8P12 | keratin 8 pseudogene 12 |
| LMNB1 | lamin B1 |
| LOC202181 | SUMO-interacting motifs containing 1 pseudogene |
| LRIG2 | leucine-rich repeats and immunoglobulin-like domains 2 |
| MAGEF1 | melanoma antigen family F1 |
| MAP4K2 | mitogen-activated protein kinase kinase kinase kinase 2 |
| MEFV | Mediterranean fever |
| MOCS3 | molybdenum cofactor synthesis 3 |
| MVP | major vault protein |
| NPIPB15 | nuclear pore complex interacting protein family, member B15 |
| NR1H3 | nuclear receptor subfamily 1, group H, member 3 |
| OR7E47P | olfactory receptor, family 7, subfamily E, member 47 pseudogene |
| OSMR | oncostatin M receptor |
| PAK6 | p21 protein (Cdc42/Rac)-activated kinase 6 |
| PMCH | pro-melanin-concentrating hormone |
| PRB3 | proline-rich protein BstNI subfamily 3 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta |
| PRR4 | proline rich 4 (lacrimal) |
| RAB33B | RAB33B, member RAS oncogene family |
| RAB3A | RAB3A, member RAS oncogene family |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 |
| SNORA21 | small nucleolar RNA, H/ACA box 21 |
| STON1 | stonin 1 |
| STRN | striatin, calmodulin binding protein |
| SYNPO | synaptopodin |
| TAB1 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| TAOK1 | TAO kinase 1 |
| TBC1D8B | TBC1 domain family, member 8B (with GRAM domain) |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 |
| TCF7L1 | transcription factor 7-like 1 (T-cell specific, HMG-box) |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) |
| TGFBI | transforming growth factor, beta-induced, 68kDa |
| THRAP3 | thyroid hormone receptor associated protein 3 |
| TOM1 | target of myb1 (chicken) |
| TTN | titin |
| TUBA4B | tubulin, alpha 4b |
| WDR25 | WD repeat domain 25 |
| XAB2 | XPA binding protein 2 |
| ZMAT5 | zinc finger, matrin-type 5 |
| ZNF134 | zinc finger protein 134 |
| ZNF141 | zinc finger protein 141 |
| ZNF214 | zinc finger protein 214 |
| ZNF391 | zinc finger protein 391 |
| ZNF768 | zinc finger protein 768 |
| ZNF816 | zinc finger protein 816 |
