methotrexate Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A pteridine that has formula C20H22N8O5. (Chemical Entities of Biological Interest Ontology, CHEBI_44185)
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Genes

52 genes co-occuring with the biological term methotrexate in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADORA2A adenosine A2a receptor
AIF1 allograft inflammatory factor 1
AMPD1 adenosine monophosphate deaminase 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
BSG basigin (Ok blood group)
CUL1 cullin 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DHFR dihydrofolate reductase
FOLR1 folate receptor 1 (adult)
FPGS folylpolyglutamate synthase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
ICAM1 intercellular adhesion molecule 1
IL17A interleukin 17A
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
LTA lymphotoxin alpha
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NR1I3 nuclear receptor subfamily 1, group I, member 3
OCLN occludin
RAD51 RAD51 recombinase
RB1 retinoblastoma 1
S100A4 S100 calcium binding protein A4
SELE selectin E
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TCN2 transcobalamin II
TJP1 tight junction protein 1
TNF tumor necrosis factor
TPMT thiopurine S-methyltransferase
TYMS thymidylate synthetase
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
VCAM1 vascular cell adhesion molecule 1