methoxamine-2488 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the methoxamine-2488 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACTC1 actin, alpha, cardiac muscle 1
ADARB1 adenosine deaminase, RNA-specific, B1
ADD2 adducin 2 (beta)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ARHGAP26 Rho GTPase activating protein 26
ATAT1 alpha tubulin acetyltransferase 1
BMP1 bone morphogenetic protein 1
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
C1ORF68 chromosome 1 open reading frame 68
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CASKIN2 CASK interacting protein 2
CD22 CD22 molecule
CD70 CD70 molecule
CDC42 cell division cycle 42
CFAP45 cilia and flagella associated protein 45
CLCA2 chloride channel accessory 2
CNN1 calponin 1, basic, smooth muscle
CNOT2 CCR4-NOT transcription complex, subunit 2
CNTNAP1 contactin associated protein 1
COL9A3 collagen, type IX, alpha 3
COPE coatomer protein complex, subunit epsilon
CREM cAMP responsive element modulator
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDN dendrin
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHRS12 dehydrogenase/reductase (SDR family) member 12
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DOCK9 dedicator of cytokinesis 9
DTX2 deltex 2, E3 ubiquitin ligase
ELAC1 elaC ribonuclease Z 1
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
FABP3 fatty acid binding protein 3, muscle and heart
FAM49A family with sequence similarity 49, member A
FLJ11292
FOXP3 forkhead box P3
FXYD2 FXYD domain containing ion transport regulator 2
FZD4 frizzled class receptor 4
GPR182 G protein-coupled receptor 182
GRM7 glutamate receptor, metabotropic 7
GRTP1 growth hormone regulated TBC protein 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HEG1 heart development protein with EGF-like domains 1
HGD homogentisate 1,2-dioxygenase
IGHA1 immunoglobulin heavy constant alpha 1
KCNIP1 Kv channel interacting protein 1
KIAA1109 KIAA1109
KRT8P12 keratin 8 pseudogene 12
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LOXL3 lysyl oxidase-like 3
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MCM3AP minichromosome maintenance complex component 3 associated protein
MNMIP1 manchette microtubule inner protein 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTSS1L metastasis suppressor 1-like
MUC6 mucin 6, oligomeric mucus/gel-forming
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NEFM neurofilament, medium polypeptide
NF2 neurofibromin 2 (merlin)
NMT2 N-myristoyltransferase 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDIA2 protein disulfide isomerase family A, member 2
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLP1 proteolipid protein 1
PNPLA3 patatin-like phospholipase domain containing 3
PRB1 proline-rich protein BstNI subfamily 1
PRLH prolactin releasing hormone
PROX1 prospero homeobox 1
RAB11B RAB11B, member RAS oncogene family
RANBP1 RAN binding protein 1
RAPSN receptor-associated protein of the synapse
SBNO2 strawberry notch homolog 2 (Drosophila)
SCN5A sodium channel, voltage gated, type V alpha subunit
SH3PXD2A SH3 and PX domains 2A
SIRPA signal-regulatory protein alpha
SLC17A2 solute carrier family 17, member 2
SMAD3 SMAD family member 3
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SOWAHC sosondowah ankyrin repeat domain family member C
SPTBN5 spectrin, beta, non-erythrocytic 5
STARD13 StAR-related lipid transfer (START) domain containing 13
STEAP4 STEAP family member 4
TAL1 T-cell acute lymphocytic leukemia 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TK2 thymidine kinase 2, mitochondrial
TLN2 talin 2
TMEM63A transmembrane protein 63A
TMOD1 tropomodulin 1
TOB2 transducer of ERBB2, 2
XYLB xylulokinase homolog (H. influenzae)

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ART1 ADP-ribosyltransferase 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAG4 BCL2-associated athanogene 4
C17ORF70 chromosome 17 open reading frame 70
C7ORF43 chromosome 7 open reading frame 43
C9ORF9 chromosome 9 open reading frame 9
CARF calcium responsive transcription factor
CCRL2 chemokine (C-C motif) receptor-like 2
CDC37L1 cell division cycle 37-like 1
CDR2L cerebellar degeneration-related protein 2-like
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLCF1 cardiotrophin-like cytokine factor 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EML4 echinoderm microtubule associated protein like 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM127A family with sequence similarity 127, member A
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GALK1 galactokinase 1
GK3P glycerol kinase 3 pseudogene
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPN2 GPN-loop GTPase 2
GTF2I general transcription factor IIi
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HSPA1L heat shock 70kDa protein 1-like
ICAM5 intercellular adhesion molecule 5, telencephalin
IFI6 interferon, alpha-inducible protein 6
INO80D INO80 complex subunit D
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCTD7 potassium channel tetramerization domain containing 7
KLF1 Kruppel-like factor 1 (erythroid)
LMTK1 lemur tail kinase 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MCTP2 multiple C2 domains, transmembrane 2
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MLPH melanophilin
MPDU1 mannose-P-dolichol utilization defect 1
NBEAL2 neurobeachin-like 2
NCALD neurocalcin delta
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5M 5',3'-nucleotidase, mitochondrial
PADI2 peptidyl arginine deiminase, type II
PARG poly (ADP-ribose) glycohydrolase
PGM3 phosphoglucomutase 3
PGP phosphoglycolate phosphatase
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCD1 phospholipase C, delta 1
PNOC prepronociceptin
POLL polymerase (DNA directed), lambda
POM121L2 POM121 transmembrane nucleoporin-like 2
PORCN porcupine homolog (Drosophila)
PYGB phosphorylase, glycogen; brain
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RARS arginyl-tRNA synthetase
RHOH ras homolog family member H
RIN1 Ras and Rab interactor 1
RNF122 ring finger protein 122
RPGR retinitis pigmentosa GTPase regulator
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCAMP5 secretory carrier membrane protein 5
SCG5 secretogranin V
SERGEF secretion regulating guanine nucleotide exchange factor
SGPP1 sphingosine-1-phosphate phosphatase 1
SHPK sedoheptulokinase
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNX29P2 sorting nexin 29 pseudogene 2
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STX5 syntaxin 5
SYNC syncoilin, intermediate filament protein
TAOK1 TAO kinase 1
TBC1D17 TBC1 domain family, member 17
TBCCD1 TBCC domain containing 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM53 transmembrane protein 53
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TUBA4B tubulin, alpha 4b
VN1R1 vomeronasal 1 receptor 1
VNN2 vanin 2
WASF3 WAS protein family, member 3
WDR62 WD repeat domain 62
YY2 YY2 transcription factor
ZC2HC1A zinc finger, C2HC-type containing 1A
ZNF529 zinc finger protein 529
ZNF747 zinc finger protein 747