methoxamine-2848 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the methoxamine-2848 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRL1 adhesion G protein-coupled receptor L1
AGRN agrin
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKH ANKH inorganic pyrophosphate transport regulator
APOC1 apolipoprotein C-I
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATXN2L ataxin 2-like
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C17ORF59 chromosome 17 open reading frame 59
C2 complement component 2
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CACYBP calcyclin binding protein
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC132 coiled-coil domain containing 132
CCDC68 coiled-coil domain containing 68
CDK3 cyclin-dependent kinase 3
CEP250 centrosomal protein 250kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC11A C-type lectin domain family 11, member A
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COL18A1 collagen, type XVIII, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTSF cathepsin F
CXXC1 CXXC finger protein 1
DBP D site of albumin promoter (albumin D-box) binding protein
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DHODH dihydroorotate dehydrogenase (quinone)
DUSP1 dual specificity phosphatase 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EIF1 eukaryotic translation initiation factor 1
FAM110B family with sequence similarity 110, member B
FFAR2 free fatty acid receptor 2
FHL1 four and a half LIM domains 1
FKRP fukutin related protein
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAB1 GRB2-associated binding protein 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GEM GTP binding protein overexpressed in skeletal muscle
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HSF1 heat shock transcription factor 1
IDS iduronate 2-sulfatase
INHBE inhibin, beta E
ITGB4 integrin, beta 4
JAG2 jagged 2
KDM4B lysine (K)-specific demethylase 4B
KHK ketohexokinase (fructokinase)
KYNU kynureninase
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MAPK10 mitogen-activated protein kinase 10
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME5 NME/NM23 family member 5
PADI1 peptidyl arginine deiminase, type I
PALM paralemmin
PCDHB6 protocadherin beta 6
PFKL phosphofructokinase, liver
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
POU3F2 POU class 3 homeobox 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RABGAP1 RAB GTPase activating protein 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF43 ring finger protein 43
RUNX2 runt-related transcription factor 2
SCAP SREBF chaperone
SH3BP2 SH3-domain binding protein 2
SIVA1 SIVA1, apoptosis-inducing factor
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOCS7 suppressor of cytokine signaling 7
STAC SH3 and cysteine rich domain
SUN2 Sad1 and UNC84 domain containing 2
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TBC1D30 TBC1 domain family, member 30
TGIF2 TGFB-induced factor homeobox 2
TK2 thymidine kinase 2, mitochondrial
TMC6 transmembrane channel-like 6
TMEM53 transmembrane protein 53
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TRAK1 trafficking protein, kinesin binding 1
TRIO trio Rho guanine nucleotide exchange factor
YIPF2 Yip1 domain family, member 2
ZBED1 zinc finger, BED-type containing 1
ZFHX4 zinc finger homeobox 4
ZFPL1 zinc finger protein-like 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF14 zinc finger protein 14
ZNF446 zinc finger protein 446
ZNF592 zinc finger protein 592
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALOX15 arachidonate 15-lipoxygenase
ANKEF1 ankyrin repeat and EF-hand domain containing 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARC activity-regulated cytoskeleton-associated protein
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BIK BCL2-interacting killer (apoptosis-inducing)
C11ORF30 chromosome 11 open reading frame 30
C11ORF80 chromosome 11 open reading frame 80
C1ORF105 chromosome 1 open reading frame 105
CA11 carbonic anhydrase XI
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAPG capping protein (actin filament), gelsolin-like
CDC42SE1 CDC42 small effector 1
CIC capicua transcriptional repressor
CLGN calmegin
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COL4A5 collagen, type IV, alpha 5
CORT cortistatin
CSTA cystatin A (stefin A)
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP2 dual specificity phosphatase 2
ECHDC1 ethylmalonyl-CoA decarboxylase 1
EPHA2 EPH receptor A2
FAM184A family with sequence similarity 184, member A
FAM198B family with sequence similarity 198, member B
FAM212B family with sequence similarity 212, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FGF23 fibroblast growth factor 23
FLRT3 fibronectin leucine rich transmembrane protein 3
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR27 G protein-coupled receptor 27
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AL histone cluster 1, H2al
HIST1H2BF histone cluster 1, H2bf
HIST1H2BO histone cluster 1, H2bo
HLA-J major histocompatibility complex, class I, J (pseudogene)
HP1BP3 heterochromatin protein 1, binding protein 3
INPP5J inositol polyphosphate-5-phosphatase J
JMJD4 jumonji domain containing 4
KLHL21 kelch-like family member 21
LPXN leupaxin
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRP2 low density lipoprotein receptor-related protein 2
LRRC37A2 leucine rich repeat containing 37, member A2
LYRM9 LYR motif containing 9
MB myoglobin
MCOLN1 mucolipin 1
MDM4 MDM4, p53 regulator
MEFV Mediterranean fever
NIPAL2 NIPA-like domain containing 2
NPTX1 neuronal pentraxin I
NPY1R neuropeptide Y receptor Y1
PAIP2B poly(A) binding protein interacting protein 2B
PCBP4 poly(rC) binding protein 4
PCDHB3 protocadherin beta 3
PHEX phosphate regulating endopeptidase homolog, X-linked
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
POLH polymerase (DNA directed), eta
POMT2 protein-O-mannosyltransferase 2
PRR4 proline rich 4 (lacrimal)
QSER1 glutamine and serine rich 1
RAB30 RAB30, member RAS oncogene family
RAB33B RAB33B, member RAS oncogene family
RAB40C RAB40C, member RAS oncogene family
RHOH ras homolog family member H
RLN1 relaxin 1
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
SCNN1B sodium channel, non voltage gated 1 beta subunit
SETD1A SET domain containing 1A
SIX1 SIX homeobox 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMA4 glucuronidase, beta pseudogene
SPON2 spondin 2, extracellular matrix protein
SPRYD7 SPRY domain containing 7
ST5 suppression of tumorigenicity 5
STRN striatin, calmodulin binding protein
SYNC syncoilin, intermediate filament protein
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TLR5 toll-like receptor 5
TPK1 thiamin pyrophosphokinase 1
TRIM36 tripartite motif containing 36
TUBA3C tubulin, alpha 3c
TWISTNB TWIST neighbor
VGF VGF nerve growth factor inducible
WDR33 WD repeat domain 33
WLS wntless Wnt ligand secretion mediator
ZNF136 zinc finger protein 136
ZNF141 zinc finger protein 141
ZNF34 zinc finger protein 34