methoxamine-4972 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the methoxamine-4972 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHI1 Abelson helper integration site 1
AK1 adenylate kinase 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARHGAP44 Rho GTPase activating protein 44
ASPH aspartate beta-hydroxylase
ATP11A ATPase, class VI, type 11A
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BMP4 bone morphogenetic protein 4
C14ORF79 chromosome 14 open reading frame 79
CALCR calcitonin receptor
CASKIN2 CASK interacting protein 2
CCDC85C coiled-coil domain containing 85C
CDHR2 cadherin-related family member 2
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEP135 centrosomal protein 135kDa
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CUL9 cullin 9
CXCR4 chemokine (C-X-C motif) receptor 4
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DSN1 DSN1, MIS12 kinetochore complex component
EFR3B EFR3 homolog B (S. cerevisiae)
EGR3 early growth response 3
ENDOD1 endonuclease domain containing 1
FAM134B family with sequence similarity 134, member B
FAM46C family with sequence similarity 46, member C
FGFR1 fibroblast growth factor receptor 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAS7 growth arrest-specific 7
GLIPR1 GLI pathogenesis-related 1
GM2A GM2 ganglioside activator
GPER1 G protein-coupled estrogen receptor 1
GPM6B glycoprotein M6B
GPR137 G protein-coupled receptor 137
GRK5 G protein-coupled receptor kinase 5
GSTA4 glutathione S-transferase alpha 4
HCRP1 hepatocellular carcinoma-related HCRP1
HOMER3 homer scaffolding protein 3
HPN hepsin
HPS1 Hermansky-Pudlak syndrome 1
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INO80B INO80 complex subunit B
KMT2A lysine (K)-specific methyltransferase 2A
LINC00339 long intergenic non-protein coding RNA 339
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLE1 notchless homolog 1 (Drosophila)
NXPE3 neurexophilin and PC-esterase domain family, member 3
NXPH3 neurexophilin 3
PARD3 par-3 family cell polarity regulator
PAX5 paired box 5
PCDHGB5 protocadherin gamma subfamily B, 5
PCNX pecanex homolog (Drosophila)
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1 PDZ domain containing 1
PGR progesterone receptor
PHF3 PHD finger protein 3
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCG1 phospholipase C, gamma 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POMT2 protein-O-mannosyltransferase 2
RAD54L2 RAD54-like 2 (S. cerevisiae)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RARG retinoic acid receptor, gamma
RBM5 RNA binding motif protein 5
RGS12 regulator of G-protein signaling 12
RIOK3 RIO kinase 3
RPL10L ribosomal protein L10-like
RPLP2 ribosomal protein, large, P2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A4 solute carrier family 16, member 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SOD2 superoxide dismutase 2, mitochondrial
SRCAP Snf2-related CREBBP activator protein
SUN1 Sad1 and UNC84 domain containing 1
TEP1 telomerase-associated protein 1
THAP3 THAP domain containing, apoptosis associated protein 3
THOC5 THO complex 5
TLR5 toll-like receptor 5
TMEM63A transmembrane protein 63A
TP53I11 tumor protein p53 inducible protein 11
TRIM36 tripartite motif containing 36
TXNL4A thioredoxin-like 4A
UBOX5 U-box domain containing 5
USP19 ubiquitin specific peptidase 19
WIPF1 WAS/WASL interacting protein family, member 1
ZBTB43 zinc finger and BTB domain containing 43
ZC3H7B zinc finger CCCH-type containing 7B
ZER1 zyg-11 related, cell cycle regulator
ZNF492 zinc finger protein 492

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACBD4 acyl-CoA binding domain containing 4
AGMAT agmatine ureohydrolase (agmatinase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ASIC3 acid sensing (proton gated) ion channel 3
ATP10D ATPase, class V, type 10D
BAHCC1 BAH domain and coiled-coil containing 1
BAK1 BCL2-antagonist/killer 1
BATF basic leucine zipper transcription factor, ATF-like
BCL2A1 BCL2-related protein A1
BLNK B-cell linker
C19ORF73 chromosome 19 open reading frame 73
CCDC130 coiled-coil domain containing 130
CCDC9 coiled-coil domain containing 9
CCNK cyclin K
CDKL3 cyclin-dependent kinase-like 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN1 claudin 1
CLEC4E C-type lectin domain family 4, member E
CLSTN2 calsyntenin 2
CNGB3 cyclic nucleotide gated channel beta 3
CPTP ceramide-1-phosphate transfer protein
CRIP1 cysteine-rich protein 1 (intestinal)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DYSF dysferlin
EFHD1 EF-hand domain family, member D1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
FAM160B2 family with sequence similarity 160, member B2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL2 F-box and leucine-rich repeat protein 2
FBXL6 F-box and leucine-rich repeat protein 6
FBXO22 F-box protein 22
FGD1 FYVE, RhoGEF and PH domain containing 1
FSCN3 fascin actin-bundling protein 3, testicular
GPR157 G protein-coupled receptor 157
HAMP hepcidin antimicrobial peptide
HCAR3 hydroxycarboxylic acid receptor 3
HOXA4 homeobox A4
HOXC13 homeobox C13
HSPA1L heat shock 70kDa protein 1-like
IFI27 interferon, alpha-inducible protein 27
IL1B interleukin 1, beta
IL22 interleukin 22
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA10 integrin, alpha 10
KDM5C lysine (K)-specific demethylase 5C
KLF2 Kruppel-like factor 2
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LPPR1 lipid phosphate phosphatase-related protein type 1
LTC4S leukotriene C4 synthase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MCTP1 multiple C2 domains, transmembrane 1
MEFV Mediterranean fever
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL41 mitochondrial ribosomal protein L41
MYF5 myogenic factor 5
NDE1 nudE neurodevelopment protein 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5E 5'-nucleotidase, ecto (CD73)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PLD3 phospholipase D family, member 3
PORCN porcupine homolog (Drosophila)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RLN1 relaxin 1
RNF43 ring finger protein 43
RPAP1 RNA polymerase II associated protein 1
S100A4 S100 calcium binding protein A4
SETD1A SET domain containing 1A
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIX1 SIX homeobox 1
SLIT2 slit homolog 2 (Drosophila)
SPINK5 serine peptidase inhibitor, Kazal type 5
SREK1IP1 SREK1-interacting protein 1
STK16 serine/threonine kinase 16
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TMEM104 transmembrane protein 104
TMEM212 transmembrane protein 212
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
UBQLN4 ubiquilin 4
USP27X ubiquitin specific peptidase 27, X-linked
VLDLR very low density lipoprotein receptor
VPS9D1 VPS9 domain containing 1
WDR91 WD repeat domain 91
ZBTB48 zinc finger and BTB domain containing 48
ZNF16 zinc finger protein 16
ZNF276 zinc finger protein 276
ZNF428 zinc finger protein 428
ZNF862 zinc finger protein 862
ZSWIM1 zinc finger, SWIM-type containing 1