methoxamine-6627 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the methoxamine-6627 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAM23 ADAM metallopeptidase domain 23
AGTPBP1 ATP/GTP binding protein 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOB aldolase B, fructose-bisphosphate
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
B3GAT1 beta-1,3-glucuronyltransferase 1
BAIAP3 BAI1-associated protein 3
C14ORF1 chromosome 14 open reading frame 1
C8B complement component 8, beta polypeptide
CCDC132 coiled-coil domain containing 132
CCDC181 coiled-coil domain containing 181
CD22 CD22 molecule
CD58 CD58 molecule
CERS4 ceramide synthase 4
CNGA1 cyclic nucleotide gated channel alpha 1
CNTFR ciliary neurotrophic factor receptor
DGKE diacylglycerol kinase, epsilon 64kDa
DNAAF1 dynein, axonemal, assembly factor 1
DNASE1L3 deoxyribonuclease I-like 3
DOCK5 dedicator of cytokinesis 5
DOK4 docking protein 4
DUSP1 dual specificity phosphatase 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EDNRA endothelin receptor type A
ELOVL5 ELOVL fatty acid elongase 5
EMC3 ER membrane protein complex subunit 3
EMID1 EMI domain containing 1
EXPH5 exophilin 5
FGF1 fibroblast growth factor 1 (acidic)
FGF18 fibroblast growth factor 18
FGFR1 fibroblast growth factor receptor 1
FRMPD1 FERM and PDZ domain containing 1
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GSPT1 G1 to S phase transition 1
GZMK granzyme K (granzyme 3; tryptase II)
HCRTR2 hypocretin (orexin) receptor 2
IDS iduronate 2-sulfatase
IGL immunoglobulin lambda locus
IL22 interleukin 22
IL33R interleukin 33 receptor
ITGB7 integrin, beta 7
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIAA1456 KIAA1456
KLHL25 kelch-like family member 25
LEF1 lymphoid enhancer-binding factor 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LILRP2 leukocyte immunoglobulin-like receptor pseudogene 2
MAGEB2 melanoma antigen family B2
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NACAD NAC alpha domain containing
NNAT neuronatin
NTNG1 netrin G1
PCDH1 protocadherin 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKD2L2 polycystic kidney disease 2-like 2
PLA2G1B phospholipase A2, group IB (pancreas)
PLCH1 phospholipase C, eta 1
POU6F2 POU class 6 homeobox 2
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PROL1 proline rich, lacrimal 1
PROX1 prospero homeobox 1
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAB3B RAB3B, member RAS oncogene family
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RPL35A ribosomal protein L35a
SBNO1 strawberry notch homolog 1 (Drosophila)
SCN2B sodium channel, voltage gated, type II beta subunit
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SMC1A structural maintenance of chromosomes 1A
SMG7 SMG7 nonsense mediated mRNA decay factor
SOS2 son of sevenless homolog 2 (Drosophila)
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STS steroid sulfatase (microsomal), isozyme S
TBX1 T-box 1
TCP10 t-complex 10
TCP10L t-complex 10-like
TIMELESS timeless circadian clock
TLDC1 TBC/LysM-associated domain containing 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TRA T cell receptor alpha locus
TRD T cell receptor delta locus
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBE2B ubiquitin-conjugating enzyme E2B
USP34 ubiquitin specific peptidase 34
UTF1 undifferentiated embryonic cell transcription factor 1
VWA5A von Willebrand factor A domain containing 5A
WSB1 WD repeat and SOCS box containing 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZCCHC14 zinc finger, CCHC domain containing 14
ZNF480 zinc finger protein 480
ZNF536 zinc finger protein 536

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADTRP androgen-dependent TFPI-regulating protein
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA2P1 annexin A2 pseudogene 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMC6 armadillo repeat containing 6
AXIN1 axin 1
BAHCC1 BAH domain and coiled-coil containing 1
C14ORF79 chromosome 14 open reading frame 79
C17ORF53 chromosome 17 open reading frame 53
C17ORF70 chromosome 17 open reading frame 70
C17ORF80 chromosome 17 open reading frame 80
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C22ORF29 chromosome 22 open reading frame 29
CA5BP1 carbonic anhydrase VB pseudogene 1
CCNO cyclin O
CENPT centromere protein T
CHML choroideremia-like (Rab escort protein 2)
CHMP6 charged multivesicular body protein 6
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CNN2 calponin 2
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CUZD1 CUB and zona pellucida-like domains 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL3 chemokine (C-X-C motif) ligand 3
DDN dendrin
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FSD1 fibronectin type III and SPRY domain containing 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
HIST1H1D histone cluster 1, H1d
HIST1H4E histone cluster 1, H4e
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFNA14 interferon, alpha 14
INPPL1 inositol polyphosphate phosphatase-like 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KIAA0319L KIAA0319-like
KIAA0922 KIAA0922
LIPG lipase, endothelial
MDM4 MDM4, p53 regulator
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MNDA myeloid cell nuclear differentiation antigen
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPS34 mitochondrial ribosomal protein S34
MYO1F myosin IF
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEUROD4 neuronal differentiation 4
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NOTCH1 notch 1
NPFFR1 neuropeptide FF receptor 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PER3 period circadian clock 3
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLD3 phospholipase D family, member 3
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLXNB3 plexin B3
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PRB3 proline-rich protein BstNI subfamily 3
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTK7 protein tyrosine kinase 7 (inactive)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAI2 retinoic acid induced 2
RHOBTB2 Rho-related BTB domain containing 2
SH2B1 SH2B adaptor protein 1
SIRAL2 SIR2 antiphage like 2
SIX3 SIX homeobox 3
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYNPO synaptopodin
TAS2R10 taste receptor, type 2, member 10
THBS3 thrombospondin 3
TMEM209 transmembrane protein 209
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBA4B tubulin, alpha 4b
TXK TXK tyrosine kinase
ULBP2 UL16 binding protein 2
VWA1 von Willebrand factor A domain containing 1
WDR18 WD repeat domain 18
WDR4 WD repeat domain 4
ZBTB22 zinc finger and BTB domain containing 22
ZFP30 ZFP30 zinc finger protein
ZNF141 zinc finger protein 141
ZNF428 zinc finger protein 428
ZNF639 zinc finger protein 639
ZNF768 zinc finger protein 768