methylbenzethonium chloride-2190 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the methylbenzethonium chloride-2190 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APC adenomatous polyposis coli
APOE apolipoprotein E
ATP13A2 ATPase type 13A2
BIN1 bridging integrator 1
BIRC3 baculoviral IAP repeat containing 3
CCNG2 cyclin G2
CCSER2 coiled-coil serine-rich protein 2
CDC25C cell division cycle 25C
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CFAP45 cilia and flagella associated protein 45
CFAP74 cilia and flagella associated protein 74
CHPF chondroitin polymerizing factor
COL10A1 collagen, type X, alpha 1
COL4A2 collagen, type IV, alpha 2
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CPEB3 cytoplasmic polyadenylation element binding protein 3
CSNK1G1 casein kinase 1, gamma 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CUL7 cullin 7
CYLD cylindromatosis (turban tumor syndrome)
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DCTN2 dynactin 2 (p50)
DLX2 distal-less homeobox 2
DOPEY2 dopey family member 2
ERBB2 erb-b2 receptor tyrosine kinase 2
F11R F11 receptor
FAM120C family with sequence similarity 120C
FAM76A family with sequence similarity 76, member A
FGF23 fibroblast growth factor 23
FLOT1 flotillin 1
FMO5 flavin containing monooxygenase 5
GLE1 GLE1 RNA export mediator
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HDAC11 histone deacetylase 11
HIST1H1D histone cluster 1, H1d
HOXA1 homeobox A1
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL3RA interleukin 3 receptor, alpha (low affinity)
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQSEC1 IQ motif and Sec7 domain 1
JAK2 Janus kinase 2
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KIAA1024 KIAA1024
LCMT2 leucine carboxyl methyltransferase 2
LMF2 lipase maturation factor 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MAU2 MAU2 sister chromatid cohesion factor
MDFI MyoD family inhibitor
MT1G metallothionein 1G
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUM1 melanoma associated antigen (mutated) 1
N4BP2L1 NEDD4 binding protein 2-like 1
NEK2 NIMA-related kinase 2
NOP16 NOP16 nucleolar protein
NOV nephroblastoma overexpressed
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
PAPPA2 pappalysin 2
PDE4DIP phosphodiesterase 4D interacting protein
PLD1 phospholipase D1, phosphatidylcholine-specific
POU6F1 POU class 6 homeobox 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RANBP17 RAN binding protein 17
RANBP3 RAN binding protein 3
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RB1 retinoblastoma 1
RHEB Ras homolog enriched in brain
RUFY3 RUN and FYVE domain containing 3
SBNO2 strawberry notch homolog 2 (Drosophila)
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SELPLG selectin P ligand
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMAD3 SMAD family member 3
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPTB spectrin, beta, erythrocytic
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STARD13 StAR-related lipid transfer (START) domain containing 13
STK11 serine/threonine kinase 11
TAAR5 trace amine associated receptor 5
TAZ tafazzin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM140 transmembrane protein 140
TMEM254 transmembrane protein 254
TSKS testis-specific serine kinase substrate
UBE2I ubiquitin-conjugating enzyme E2I
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
WRAP53 WD repeat containing, antisense to TP53
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF428 zinc finger protein 428
ZNF609 zinc finger protein 609
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACPP acid phosphatase, prostate
ADM adrenomedullin
ADORA3 adenosine A3 receptor
ALS2CL ALS2 C-terminal like
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ATF3 activating transcription factor 3
BATF3 basic leucine zipper transcription factor, ATF-like 3
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
C16ORF59 chromosome 16 open reading frame 59
C5ORF45 chromosome 5 open reading frame 45
CCDC132 coiled-coil domain containing 132
CCDC71 coiled-coil domain containing 71
CCDC85C coiled-coil domain containing 85C
CD1D CD1d molecule
CD300C CD300c molecule
CD320 CD320 molecule
CD34 CD34 molecule
CD69 CD69 molecule
CDKL3 cyclin-dependent kinase-like 3
CEP170B centrosomal protein 170B
CFP complement factor properdin
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP6 charged multivesicular body protein 6
CHST10 carbohydrate sulfotransferase 10
CIDEC cell death-inducing DFFA-like effector c
CLCN2 chloride channel, voltage-sensitive 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDN dendrin
DGKG diacylglycerol kinase, gamma 90kDa
DOK3 docking protein 3
DUSP8 dual specificity phosphatase 8
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA3 ephrin-A3
ELP6 elongator acetyltransferase complex subunit 6
ENO2 enolase 2 (gamma, neuronal)
ERN2 endoplasmic reticulum to nucleus signaling 2
FRMD1 FERM domain containing 1
GJA1 gap junction protein, alpha 1, 43kDa
GPR27 G protein-coupled receptor 27
GRPR gastrin-releasing peptide receptor
GTF2IRD1 GTF2I repeat domain containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1T histone cluster 1, H1t
IL22 interleukin 22
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KRT8P12 keratin 8 pseudogene 12
LIMS2 LIM and senescent cell antigen-like domains 2
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MMP9 matrix metallopeptidase 9
NBEA neurobeachin
NDRG1 N-myc downstream regulated 1
NIPAL2 NIPA-like domain containing 2
NPFFR1 neuropeptide FF receptor 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PADI2 peptidyl arginine deiminase, type II
PDZD7 PDZ domain containing 7
PECR peroxisomal trans-2-enoyl-CoA reductase
PER3 period circadian clock 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCD1 phospholipase C, delta 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLTP phospholipid transfer protein
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RGS13 regulator of G-protein signaling 13
RGS16 regulator of G-protein signaling 16
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPAP1 RNA polymerase II associated protein 1
S1PR4 sphingosine-1-phosphate receptor 4
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TAGLN transgelin
TGFBR3 transforming growth factor, beta receptor III
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRAF2 TNF receptor-associated factor 2
TSC22D4 TSC22 domain family, member 4
USB1 U6 snRNA biogenesis 1
VN1R1 vomeronasal 1 receptor 1
WASF3 WAS protein family, member 3
WNT10B wingless-type MMTV integration site family, member 10B
ZNF395 zinc finger protein 395
ZSCAN5A zinc finger and SCAN domain containing 5A