methylbenzethonium chloride-6045 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the methylbenzethonium chloride-6045 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMPD3 adenosine monophosphate deaminase 3
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASTN1 astrotactin 1
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BIRC7 baculoviral IAP repeat containing 7
BMP8B bone morphogenetic protein 8b
C11ORF16 chromosome 11 open reading frame 16
C14ORF79 chromosome 14 open reading frame 79
C1ORF54 chromosome 1 open reading frame 54
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCNG2 cyclin G2
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFAP45 cilia and flagella associated protein 45
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL4A2 collagen, type IV, alpha 2
COL9A3 collagen, type IX, alpha 3
CREBBP CREB binding protein
CSDC2 cold shock domain containing C2, RNA binding
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DOK4 docking protein 4
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGR1 early growth response 1
FAM182B family with sequence similarity 182, member B
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF18 fibroblast growth factor 18
FGF3 fibroblast growth factor 3
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GDF2 growth differentiation factor 2
GEM GTP binding protein overexpressed in skeletal muscle
GSTTP1 glutathione S-transferase theta pseudogene 1
HAS2 hyaluronan synthase 2
HRH3 histamine receptor H3
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IDUA iduronidase, alpha-L-
IL21R interleukin 21 receptor
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITGB7 integrin, beta 7
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KLF12 Kruppel-like factor 12
KLHL24 kelch-like family member 24
KLHL25 kelch-like family member 25
KRT83 keratin 83, type II
LPAR3 lysophosphatidic acid receptor 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAG myelin associated glycoprotein
MAOA monoamine oxidase A
MEGF6 multiple EGF-like-domains 6
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MUC8 mucin 8
MXD4 MAX dimerization protein 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NHLH1 nescient helix loop helix 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPRK1 opioid receptor, kappa 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PCDHB12 protocadherin beta 12
PCDHGA10 protocadherin gamma subfamily A, 10
PDE11A phosphodiesterase 11A
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLTP phospholipid transfer protein
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTTG2 pituitary tumor-transforming 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SOX15 SRY (sex determining region Y)-box 15
SPRR2B small proline-rich protein 2B
SRGN serglycin
TAPBP TAP binding protein (tapasin)
TBC1D22B TBC1 domain family, member 22B
TMBIM1 transmembrane BAX inhibitor motif containing 1
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
YOD1 YOD1 deubiquitinase
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
ACTL8 actin-like 8
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADM adrenomedullin
AEN apoptosis enhancing nuclease
AKAP7 A kinase (PRKA) anchor protein 7
AMPD2 adenosine monophosphate deaminase 2
APOLD1 apolipoprotein L domain containing 1
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARMC4 armadillo repeat containing 4
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
C1ORF35 chromosome 1 open reading frame 35
C1QTNF3 C1q and tumor necrosis factor related protein 3
C8ORF44 chromosome 8 open reading frame 44
CAPN15 calpain 15
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNE1 cyclin E1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLEC16A C-type lectin domain family 16, member A
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COPZ2 coatomer protein complex, subunit zeta 2
CPTP ceramide-1-phosphate transfer protein
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTSF cathepsin F
CUZD1 CUB and zona pellucida-like domains 1
DEXI Dexi homolog (mouse)
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DUSP2 dual specificity phosphatase 2
EFHD2 EF-hand domain family, member D2
EFNA3 ephrin-A3
EGLN3 egl-9 family hypoxia-inducible factor 3
ELOVL4 ELOVL fatty acid elongase 4
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EXD3 exonuclease 3'-5' domain containing 3
FMOD fibromodulin
FOXI1 forkhead box I1
FURIN furin (paired basic amino acid cleaving enzyme)
GEMIN8 gem (nuclear organelle) associated protein 8
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPATCH3 G patch domain containing 3
GPR21 G protein-coupled receptor 21
GPX2 glutathione peroxidase 2
HDAC4 histone deacetylase 4
HOXC5 homeobox C5
IDI2-AS1 IDI2 antisense RNA 1
INPP5J inositol polyphosphate-5-phosphatase J
IRAK4 interleukin-1 receptor-associated kinase 4
IREB2 iron-responsive element binding protein 2
LMX1B LIM homeobox transcription factor 1, beta
LY6D lymphocyte antigen 6 complex, locus D
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MORN1 MORN repeat containing 1
MRPL44 mitochondrial ribosomal protein L44
MSI1 musashi RNA-binding protein 1
NDOR1 NADPH dependent diflavin oxidoreductase 1
NLRX1 NLR family member X1
NOD1 nucleotide-binding oligomerization domain containing 1
NT5DC3 5'-nucleotidase domain containing 3
OSMR oncostatin M receptor
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PHOX2A paired-like homeobox 2a
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMP22 peripheral myelin protein 22
POMT2 protein-O-mannosyltransferase 2
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNF122 ring finger protein 122
RNF2 ring finger protein 2
RNF208 ring finger protein 208
SCAMP3 secretory carrier membrane protein 3
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHARPIN SHANK-associated RH domain interactor
SIPA1 signal-induced proliferation-associated 1
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMTN smoothelin
SRPX sushi-repeat containing protein, X-linked
TEX40 testis expressed 40
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TMEM242 transmembrane protein 242
TPST2 tyrosylprotein sulfotransferase 2
TRAF5 TNF receptor-associated factor 5
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TUBA3C tubulin, alpha 3c
UBXN6 UBX domain protein 6
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
VEGFB vascular endothelial growth factor B
VIPR1 vasoactive intestinal peptide receptor 1
WLS wntless Wnt ligand secretion mediator
XK X-linked Kx blood group
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF10 zinc finger protein 10
ZNF862 zinc finger protein 862