methylergometrine-1607 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the methylergometrine-1607 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACVR1 activin A receptor, type I
ADD3 adducin 3 (gamma)
AKAP13 A kinase (PRKA) anchor protein 13
ALAD aminolevulinate dehydratase
ANXA2 annexin A2
ANXA2P2 annexin A2 pseudogene 2
ARL4C ADP-ribosylation factor-like 4C
ARRB2 arrestin, beta 2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASCC1 activating signal cointegrator 1 complex subunit 1
AXL AXL receptor tyrosine kinase
BST1 bone marrow stromal cell antigen 1
BTG1 B-cell translocation gene 1, anti-proliferative
C2ORF68 chromosome 2 open reading frame 68
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CCL20 chemokine (C-C motif) ligand 20
CCL22 chemokine (C-C motif) ligand 22
CCNG2 cyclin G2
CD38 CD38 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD86 CD86 molecule
CDC25C cell division cycle 25C
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFLAR CASP8 and FADD-like apoptosis regulator
CHN2 chimerin 2
CPNE3 copine III
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSB cathepsin B
CTSK cathepsin K
CYLD cylindromatosis (turban tumor syndrome)
DNAH17 dynein, axonemal, heavy chain 17
DOCK4 dedicator of cytokinesis 4
DUSP4 dual specificity phosphatase 4
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXN3 forkhead box N3
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
FUCA1 fucosidase, alpha-L- 1, tissue
GAB2 GRB2-associated binding protein 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR183 G protein-coupled receptor 183
GPSM2 G-protein signaling modulator 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BK histone cluster 1, H2bk
IL10RA interleukin 10 receptor, alpha
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
KLF10 Kruppel-like factor 10
KYNU kynureninase
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
NDRG2 NDRG family member 2
NINJ1 ninjurin 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
PICALM phosphatidylinositol binding clathrin assembly protein
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLSCR1 phospholipid scramblase 1
PNOC prepronociceptin
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R16B protein phosphatase 1, regulatory subunit 16B
RAB31 RAB31, member RAS oncogene family
RIN3 Ras and Rab interactor 3
RNF130 ring finger protein 130
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SGK1 serum/glucocorticoid regulated kinase 1
SLA Src-like-adaptor
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMOX spermine oxidase
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
THBS1 thrombospondin 1
THEMIS2 thymocyte selection associated family member 2
TIMP1 TIMP metallopeptidase inhibitor 1
TK2 thymidine kinase 2, mitochondrial
TPM4 tropomyosin 4
TRAF3IP3 TRAF3 interacting protein 3
ZFYVE16 zinc finger, FYVE domain containing 16

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADCK3 aarF domain containing kinase 3
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ATAD3A ATPase family, AAA domain containing 3A
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C12ORF29 chromosome 12 open reading frame 29
C19ORF24 chromosome 19 open reading frame 24
CCDC86 coiled-coil domain containing 86
CCL4 chemokine (C-C motif) ligand 4
CCNA1 cyclin A1
CD302 CD302 molecule
CD3EAP CD3e molecule, epsilon associated protein
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLUH clustered mitochondria (cluA/CLU1) homolog
CNTD2 cyclin N-terminal domain containing 2
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae)
CTPS1 CTP synthase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EBNA1BP2 EBNA1 binding protein 2
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
EXOSC5 exosome component 5
FAM216A family with sequence similarity 216, member A
FAR2 fatty acyl CoA reductase 2
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FLT3 fms-related tyrosine kinase 3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
HSPB1 heat shock 27kDa protein 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIAA0020 KIAA0020
KIAA0930 KIAA0930
KIF21B kinesin family member 21B
LAS1L LAS1-like (S. cerevisiae)
MAK16 MAK16 homolog (S. cerevisiae)
MINA MYC induced nuclear antigen
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MRPS34 mitochondrial ribosomal protein S34
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBBP1A MYB binding protein (P160) 1a
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOP2 NOP2 nucleolar protein
NUP93 nucleoporin 93kDa
PCYOX1L prenylcysteine oxidase 1 like
PDCD11 programmed cell death 11
PES1 pescadillo ribosomal biogenesis factor 1
PFAS phosphoribosylformylglycinamidine synthase
PFDN2 prefoldin subunit 2
PFKM phosphofructokinase, muscle
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRDX4 peroxiredoxin 4
PRMT3 protein arginine methyltransferase 3
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
RNF44 ring finger protein 44
RPIA ribose 5-phosphate isomerase A
RPP40 ribonuclease P/MRP 40kDa subunit
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SCO2 SCO2 cytochrome c oxidase assembly protein
SDF2L1 stromal cell-derived factor 2-like 1
SEH1L SEH1-like (S. cerevisiae)
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SRM spermidine synthase
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TFB2M transcription factor B2, mitochondrial
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TTC27 tetratricopeptide repeat domain 27
UCK2 uridine-cytidine kinase 2
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
XBP1 X-box binding protein 1
ZNF593 zinc finger protein 593
ZNHIT6 zinc finger, HIT-type containing 6