methylosome Gene Set

Dataset	COMPARTMENTS Curated Protein Localization Evidence Scores
Category	structural or functional annotations
Type	cellular component
Description	A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. (Gene Ontology, GO_0034709)
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11 proteins localized to the methylosome cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol	Name	Standardized Value
SNRPD3	small nuclear ribonucleoprotein D3 polypeptide 18kDa	0.663342
SNRPG	small nuclear ribonucleoprotein polypeptide G	0.663342
SNRPF	small nuclear ribonucleoprotein polypeptide F	0.663342
SNRPB	small nuclear ribonucleoprotein polypeptides B and B1	0.663342
SNRPN	small nuclear ribonucleoprotein polypeptide N	0.663342
CLNS1A	chloride channel, nucleotide-sensitive, 1A	0.663342
PRMT5	protein arginine methyltransferase 5	0.663342
WDR77	WD repeat domain 77	0.663342
SNRPD1	small nuclear ribonucleoprotein D1 polypeptide 16kDa	0.663342
SNRPD2	small nuclear ribonucleoprotein D2 polypeptide 16.5kDa	0.663342
SNRPE	small nuclear ribonucleoprotein polypeptide E	0.663342