methylosome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. (Gene Ontology, GO_0034709)
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32 proteins co-occuring with the methylosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
WDR77 WD repeat domain 77 2.10493
PRMT5 protein arginine methyltransferase 5 1.65934
PRMT2 protein arginine methyltransferase 2 1.43895
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 1.10664
RBM8A RNA binding motif protein 8A 0.990736
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.910182
TET1 tet methylcytosine dioxygenase 1 0.852042
MAGOHB mago-nashi homolog B (Drosophila) 0.812111
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.809359
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 0.80523
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.740064
BRWD1 bromodomain and WD repeat domain containing 1 0.689013
PRMT1 protein arginine methyltransferase 1 0.580504
CCND2 cyclin D2 0.504724
CDK6 cyclin-dependent kinase 6 0.454816
SMN2 survival of motor neuron 2, centromeric 0.392388
AR androgen receptor 0.322325
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.240636
HIST1H4C histone cluster 1, H4c 0.167125
HIST2H4B histone cluster 2, H4b 0.167125
HIST1H4B histone cluster 1, H4b 0.167125
HIST1H4A histone cluster 1, H4a 0.167125
HIST1H4I histone cluster 1, H4i 0.167125
HIST1H4H histone cluster 1, H4h 0.167125
HIST1H4J histone cluster 1, H4j 0.167125
HIST1H4K histone cluster 1, H4k 0.167125
HIST1H4D histone cluster 1, H4d 0.167125
HIST1H4E histone cluster 1, H4e 0.167125
HIST2H4A histone cluster 2, H4a 0.166884
HIST1H4L histone cluster 1, H4l 0.166884
HIST1H4F histone cluster 1, H4f 0.166884
HIST4H4 histone cluster 4, H4 0.166884