methylprednisolone-1567 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the methylprednisolone-1567 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACACB acetyl-CoA carboxylase beta
ACAN aggrecan
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRA2 adhesion G protein-coupled receptor A2
AHR aryl hydrocarbon receptor
AKT3 v-akt murine thymoma viral oncogene homolog 3
AREG amphiregulin
ATG2B autophagy related 2B
ATG4B autophagy related 4B, cysteine peptidase
AXIN1 axin 1
BATF basic leucine zipper transcription factor, ATF-like
BCAN brevican
CALR calreticulin
CCL20 chemokine (C-C motif) ligand 20
CDK12 cyclin-dependent kinase 12
CEP68 centrosomal protein 68kDa
CPD carboxypeptidase D
CTIF CBP80/20-dependent translation initiation factor
CTSB cathepsin B
DUSP1 dual specificity phosphatase 1
E2F1 E2F transcription factor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBXW4 F-box and WD repeat domain containing 4
FLT3 fms-related tyrosine kinase 3
FPR1 formyl peptide receptor 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GRIP2 glutamate receptor interacting protein 2
GRK6 G protein-coupled receptor kinase 6
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IGFBP7 insulin-like growth factor binding protein 7
IL13RA1 interleukin 13 receptor, alpha 1
IL1R2 interleukin 1 receptor, type II
INSR insulin receptor
IRAK3 interleukin-1 receptor-associated kinase 3
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KDM2A lysine (K)-specific demethylase 2A
KIF3C kinesin family member 3C
KIFC1 kinesin family member C1
KLF9 Kruppel-like factor 9
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRTM1 leucine-rich repeats and transmembrane domains 1
MBD3 methyl-CpG binding domain protein 3
METTL7A methyltransferase like 7A
MIEF1 mitochondrial elongation factor 1
MKL2 MKL/myocardin-like 2
MSH3 mutS homolog 3
MYO1C myosin IC
NCR2 natural cytotoxicity triggering receptor 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NINJ2 ninjurin 2
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OLAH oleoyl-ACP hydrolase
PARP16 poly (ADP-ribose) polymerase family, member 16
PCIF1 PDX1 C-terminal inhibiting factor 1
PER1 period circadian clock 1
PEX13 peroxisomal biogenesis factor 13
PEX7 peroxisomal biogenesis factor 7
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PSIP1 PC4 and SFRS1 interacting protein 1
PTCD1 pentatricopeptide repeat domain 1
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RECQL4 RecQ protein-like 4
RHOH ras homolog family member H
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SEC23B Sec23 homolog B (S. cerevisiae)
SERINC5 serine incorporator 5
SH2D2A SH2 domain containing 2A
SIK2 salt-inducible kinase 2
SIPA1 signal-induced proliferation-associated 1
SLA Src-like-adaptor
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC35E3 solute carrier family 35, member E3
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SRSF11 serine/arginine-rich splicing factor 11
SYN2 synapsin II
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFE3 transcription factor binding to IGHM enhancer 3
TM2D1 TM2 domain containing 1
TSC22D3 TSC22 domain family, member 3
UBL3 ubiquitin-like 3
USB1 U6 snRNA biogenesis 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WSB2 WD repeat and SOCS box containing 2
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XPA xeroderma pigmentosum, complementation group A
ZNF701 zinc finger protein 701
ZNF721 zinc finger protein 721

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACYP1 acylphosphatase 1, erythrocyte (common) type
AMT aminomethyltransferase
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BATF3 basic leucine zipper transcription factor, ATF-like 3
BLMH bleomycin hydrolase
BMS1 BMS1 ribosome biogenesis factor
BSG basigin (Ok blood group)
C11ORF95 chromosome 11 open reading frame 95
C14ORF159 chromosome 14 open reading frame 159
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCL2 chemokine (C-C motif) ligand 2
CEP85 centrosomal protein 85kDa
COA7 cytochrome c oxidase assembly factor 7 (putative)
COG7 component of oligomeric golgi complex 7
COMMD10 COMM domain containing 10
CTH cystathionine gamma-lyase
CTSH cathepsin H
CXCL8 chemokine (C-X-C motif) ligand 8
CXORF21 chromosome X open reading frame 21
CYBA cytochrome b-245, alpha polypeptide
DCAF16 DDB1 and CUL4 associated factor 16
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EMP3 epithelial membrane protein 3
FAM173A family with sequence similarity 173, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
GADD45A growth arrest and DNA-damage-inducible, alpha
GDE1 glycerophosphodiester phosphodiesterase 1
GPR18 G protein-coupled receptor 18
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
IFI6 interferon, alpha-inducible protein 6
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KIAA0020 KIAA0020
KIF3B kinesin family member 3B
LAMP5 lysosomal-associated membrane protein family, member 5
LRRC37A2 leucine rich repeat containing 37, member A2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MPP1 membrane protein, palmitoylated 1, 55kDa
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL12 mitochondrial ribosomal protein L12
MTG1 mitochondrial ribosome-associated GTPase 1
MX2 MX dynamin-like GTPase 2
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME6 NME/NM23 nucleoside diphosphate kinase 6
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOTCH1 notch 1
NPM3 nucleophosmin/nucleoplasmin 3
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUP93 nucleoporin 93kDa
ODC1 ornithine decarboxylase 1
OSGEP O-sialoglycoprotein endopeptidase
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAK1IP1 PAK1 interacting protein 1
PARL presenilin associated, rhomboid-like
PES1 pescadillo ribosomal biogenesis factor 1
PIKFYVE phosphoinositide kinase, FYVE finger containing
PMPCA peptidase (mitochondrial processing) alpha
PNPO pyridoxamine 5'-phosphate oxidase
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POU2F1 POU class 2 homeobox 1
PRDX1 peroxiredoxin 1
PSAT1 phosphoserine aminotransferase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RNF220 ring finger protein 220
RNH1 ribonuclease/angiogenin inhibitor 1
RPE ribulose-5-phosphate-3-epimerase
RPL23AP32 ribosomal protein L23a pseudogene 32
RSF1 remodeling and spacing factor 1
RUVBL1 RuvB-like AAA ATPase 1
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
STIP1 stress-induced phosphoprotein 1
STK39 serine threonine kinase 39
STRA13 stimulated by retinoic acid 13
TAC3 tachykinin 3
TEX30 testis expressed 30
THOP1 thimet oligopeptidase 1
TMEM14A transmembrane protein 14A
TOP2B topoisomerase (DNA) II beta 180kDa
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TPCN1 two pore segment channel 1
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TSG101 tumor susceptibility 101
WDR12 WD repeat domain 12
XAF1 XIAP associated factor 1
XPO7 exportin 7
ZNF12 zinc finger protein 12
ZNF197 zinc finger protein 197
ZNF536 zinc finger protein 536
ZNF85 zinc finger protein 85