metitepine-1616 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the metitepine-1616 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
AKIP1 A kinase (PRKA) interacting protein 1
ALAD aminolevulinate dehydratase
AMBRA1 autophagy/beclin-1 regulator 1
ARMCX3 armadillo repeat containing, X-linked 3
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP5SL ATP5S-like
ATXN2 ataxin 2
BSDC1 BSD domain containing 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASD1 CAS1 domain containing 1
CCHCR1 coiled-coil alpha-helical rod protein 1
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CCNT2 cyclin T2
CD300A CD300a molecule
CD5 CD5 molecule
CHD1L chromodomain helicase DNA binding protein 1-like
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLEC7A C-type lectin domain family 7, member A
CLIP1 CAP-GLY domain containing linker protein 1
CNPY3 canopy FGF signaling regulator 3
CYLD cylindromatosis (turban tumor syndrome)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DXO decapping exoribonuclease
EDC4 enhancer of mRNA decapping 4
ELMO2 engulfment and cell motility 2
EML2 echinoderm microtubule associated protein like 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETV1 ets variant 1
ETV5 ets variant 5
EVL Enah/Vasp-like
F8 coagulation factor VIII, procoagulant component
FH fumarate hydratase
GSK3A glycogen synthase kinase 3 alpha
GSTM4 glutathione S-transferase mu 4
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IMPAD1 inositol monophosphatase domain containing 1
ITGA10 integrin, alpha 10
KRBOX4 KRAB box domain containing 4
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LRMP lymphoid-restricted membrane protein
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY96 lymphocyte antigen 96
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MBTD1 mbt domain containing 1
MICALL1 MICAL-like 1
MOCS2 molybdenum cofactor synthesis 2
MTFR1 mitochondrial fission regulator 1
MTRF1L mitochondrial translational release factor 1-like
MYL10 myosin, light chain 10, regulatory
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEU1 sialidase 1 (lysosomal sialidase)
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
PAPOLA poly(A) polymerase alpha
PCIF1 PDX1 C-terminal inhibiting factor 1
PDE3B phosphodiesterase 3B, cGMP-inhibited
PGM3 phosphoglucomutase 3
PPP1R10 protein phosphatase 1, regulatory subunit 10
PROL1 proline rich, lacrimal 1
RAB28 RAB28, member RAS oncogene family
RAB33B RAB33B, member RAS oncogene family
RALB v-ral simian leukemia viral oncogene homolog B
RBMS3 RNA binding motif, single stranded interacting protein 3
RNF144A ring finger protein 144A
RNF19B ring finger protein 19B
SAMD9 sterile alpha motif domain containing 9
SGK1 serum/glucocorticoid regulated kinase 1
SLA Src-like-adaptor
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNRK SNF related kinase
SOCS3 suppressor of cytokine signaling 3
SPATS2 spermatogenesis associated, serine-rich 2
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TCF3 transcription factor 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TM7SF2 transmembrane 7 superfamily member 2
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM156 transmembrane protein 156
TRMT61A tRNA methyltransferase 61A
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
UBE2D1 ubiquitin-conjugating enzyme E2D 1
USP34 ubiquitin specific peptidase 34
VILL villin-like
WDR48 WD repeat domain 48
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XAF1 XIAP associated factor 1
YIPF1 Yip1 domain family, member 1

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACP2 acid phosphatase 2, lysosomal
ADAT1 adenosine deaminase, tRNA-specific 1
AHR aryl hydrocarbon receptor
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGAP10 Rho GTPase activating protein 10
ASB13 ankyrin repeat and SOCS box containing 13
ATAD2B ATPase family, AAA domain containing 2B
ATAD3A ATPase family, AAA domain containing 3A
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BEX1 brain expressed, X-linked 1
C11ORF68 chromosome 11 open reading frame 68
CARD9 caspase recruitment domain family, member 9
CBR1 carbonyl reductase 1
CCNT1 cyclin T1
CD302 CD302 molecule
CDKN2AIP CDKN2A interacting protein
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae)
CST3 cystatin C
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
EGLN2 egl-9 family hypoxia-inducible factor 2
ERO1L ERO1-like (S. cerevisiae)
FAM168B family with sequence similarity 168, member B
FAM173A family with sequence similarity 173, member A
FBXO5 F-box protein 5
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GEMIN6 gem (nuclear organelle) associated protein 6
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
GTPBP3 GTP binding protein 3 (mitochondrial)
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HIRA histone cell cycle regulator
IL1B interleukin 1, beta
IL4R interleukin 4 receptor
KCTD15 potassium channel tetramerization domain containing 15
KIAA0922 KIAA0922
LOC642236 FSHD region gene 1 pseudogene
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKSL1 MARCKS-like 1
MATK megakaryocyte-associated tyrosine kinase
MCMBP minichromosome maintenance complex binding protein
METTL1 methyltransferase like 1
MFSD11 major facilitator superfamily domain containing 11
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPV17 MpV17 mitochondrial inner membrane protein
MRPL2 mitochondrial ribosomal protein L2
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NFS1 NFS1 cysteine desulfurase
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NPM3 nucleophosmin/nucleoplasmin 3
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
ORC2 origin recognition complex, subunit 2
PARPBP PARP1 binding protein
PES1 pescadillo ribosomal biogenesis factor 1
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PNRC1 proline-rich nuclear receptor coactivator 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRDM13 PR domain containing 13
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGES2 prostaglandin E synthase 2
PTTG3P pituitary tumor-transforming 3, pseudogene
RAB20 RAB20, member RAS oncogene family
RBM15B RNA binding motif protein 15B
RHOC ras homolog family member C
RMDN3 regulator of microtubule dynamics 3
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SH2D3C SH2 domain containing 3C
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SRBD1 S1 RNA binding domain 1
SRRD SRR1 domain containing
STEAP3 STEAP family member 3, metalloreductase
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TCTN2 tectonic family member 2
TEX264 testis expressed 264
TFB2M transcription factor B2, mitochondrial
TMBIM4 transmembrane BAX inhibitor motif containing 4
TPCN1 two pore segment channel 1
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSLIG2 tRNA splicing ligase complex subunit 2
TTC27 tetratricopeptide repeat domain 27
TTI1 TELO2 interacting protein 1
UNG uracil-DNA glycosylase
URM1 ubiquitin related modifier 1
ZNF629 zinc finger protein 629
ZNF8 zinc finger protein 8
ZNF85 zinc finger protein 85