metoclopramide-2315 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the metoclopramide-2315 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ADCY1 adenylate cyclase 1 (brain)
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ATP10A ATPase, class V, type 10A
BTG2 BTG family, member 2
CCL22 chemokine (C-C motif) ligand 22
CD53 CD53 molecule
CD80 CD80 molecule
CD82 CD82 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CERS4 ceramide synthase 4
CIZ1 CDKN1A interacting zinc finger protein 1
CLCN4 chloride channel, voltage-sensitive 4
CNGB1 cyclic nucleotide gated channel beta 1
CNR2 cannabinoid receptor 2 (macrophage)
CUZD1 CUB and zona pellucida-like domains 1
DGCR8 DGCR8 microprocessor complex subunit
DLX2 distal-less homeobox 2
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EPHB2 EPH receptor B2
ETV5 ets variant 5
FHL1 four and a half LIM domains 1
FOXF2 forkhead box F2
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GK2 glycerol kinase 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GMPR guanosine monophosphate reductase
GPR15 G protein-coupled receptor 15
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
HIPK3 homeodomain interacting protein kinase 3
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRF4 interferon regulatory factor 4
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLK8 kallikrein-related peptidase 8
KREMEN2 kringle containing transmembrane protein 2
LENEP lens epithelial protein
LINC00216 long intergenic non-protein coding RNA 216
LYZL6 lysozyme-like 6
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MTCP1 mature T-cell proliferation 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAT6 N-acetyltransferase 6 (GCN5-related)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOV nephroblastoma overexpressed
NR2E3 nuclear receptor subfamily 2, group E, member 3
NUP88 nucleoporin 88kDa
NXPE3 neurexophilin and PC-esterase domain family, member 3
PARVB parvin, beta
PCDH1 protocadherin 1
PCNX pecanex homolog (Drosophila)
PGLYRP4 peptidoglycan recognition protein 4
PKNOX2 PBX/knotted 1 homeobox 2
PLCD1 phospholipase C, delta 1
PLTP phospholipid transfer protein
POU5F1B POU class 5 homeobox 1B
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PQLC2 PQ loop repeat containing 2
RAB6B RAB6B, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RHBDD3 rhomboid domain containing 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
S100A13 S100 calcium binding protein A13
SBNO2 strawberry notch homolog 2 (Drosophila)
SDC2 syndecan 2
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIGLEC6 sialic acid binding Ig-like lectin 6
SIK3 SIK family kinase 3
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
STAG3 stromal antigen 3
STRN striatin, calmodulin binding protein
STXBP6 syntaxin binding protein 6 (amisyn)
TAGLN3 transgelin 3
TBX6 T-box 6
TCHH trichohyalin
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TOR4A torsin family 4, member A
TRBC1 T cell receptor beta constant 1
VIM vimentin
VIPR1 vasoactive intestinal peptide receptor 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZC3H7B zinc finger CCCH-type containing 7B
ZFAND5 zinc finger, AN1-type domain 5
ZNF589 zinc finger protein 589
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADGRG2 adhesion G protein-coupled receptor G2
ARSB arylsulfatase B
ATP10D ATPase, class V, type 10D
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF30 chromosome 11 open reading frame 30
C1QTNF3 C1q and tumor necrosis factor related protein 3
C3 complement component 3
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC186 coiled-coil domain containing 186
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK3 cyclin-dependent kinase 3
CIDEB cell death-inducing DFFA-like effector b
CNGB3 cyclic nucleotide gated channel beta 3
CPPED1 calcineurin-like phosphoesterase domain containing 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DEFA4 defensin, alpha 4, corticostatin
DENND5B DENN/MADD domain containing 5B
DEPTOR DEP domain containing MTOR-interacting protein
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
EFCAB2 EF-hand calcium binding domain 2
EFNA3 ephrin-A3
ELOVL4 ELOVL fatty acid elongase 4
EMID1 EMI domain containing 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO2 F-box protein 2
FKBP5 FK506 binding protein 5
FMO4 flavin containing monooxygenase 4
GEM GTP binding protein overexpressed in skeletal muscle
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTM5 glutathione S-transferase mu 5
GSTT1 glutathione S-transferase theta 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H3B histone cluster 1, H3b
ITGA10 integrin, alpha 10
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPKB inositol-trisphosphate 3-kinase B
JMJD4 jumonji domain containing 4
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM7A lysine (K)-specific demethylase 7A
KIAA0125 KIAA0125
KIAA0894 KIAA0894 protein
KIF13A kinesin family member 13A
LHX1 LIM homeobox 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MECR mitochondrial trans-2-enoyl-CoA reductase
NLRX1 NLR family member X1
NOL12 nucleolar protein 12
NPY5R neuropeptide Y receptor Y5
NYNRIN NYN domain and retroviral integrase containing
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PCDHB13 protocadherin beta 13
PHC3 polyhomeotic homolog 3 (Drosophila)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLAC1 placenta-specific 1
PODNL1 podocan-like 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRS protein tyrosine phosphatase, receptor type, S
PTTG3P pituitary tumor-transforming 3, pseudogene
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHOBTB2 Rho-related BTB domain containing 2
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SDC3 syndecan 3
SLC16A6 solute carrier family 16, member 6
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SOWAHC sosondowah ankyrin repeat domain family member C
SPINK5 serine peptidase inhibitor, Kazal type 5
ST5 suppression of tumorigenicity 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TEX40 testis expressed 40
TGFB3 transforming growth factor, beta 3
THBS3 thrombospondin 3
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR2 toll-like receptor 2
TM6SF1 transmembrane 6 superfamily member 1
TMEM180 transmembrane protein 180
TRAIP TRAF interacting protein
TRIM5 tripartite motif containing 5
TUBGCP5 tubulin, gamma complex associated protein 5
VEGFB vascular endothelial growth factor B
ZFHX2 zinc finger homeobox 2
ZFP69B ZFP69 zinc finger protein B
ZNF165 zinc finger protein 165
ZNF205 zinc finger protein 205
ZNF212 zinc finger protein 212
ZNF442 zinc finger protein 442
ZNF480 zinc finger protein 480
ZNF506 zinc finger protein 506
ZNF652 zinc finger protein 652
ZNF747 zinc finger protein 747