metoclopramide-3625 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the metoclopramide-3625 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADGRD2 adhesion G protein-coupled receptor D2
AGXT alanine-glyoxylate aminotransferase
AMPD3 adenosine monophosphate deaminase 3
ANGPTL2 angiopoietin-like 2
ASCL1 achaete-scute family bHLH transcription factor 1
ASIC1 acid sensing (proton gated) ion channel 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C14ORF79 chromosome 14 open reading frame 79
CA10 carbonic anhydrase X
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CARD9 caspase recruitment domain family, member 9
CD177 CD177 molecule
CD58 CD58 molecule
CLCA2 chloride channel accessory 2
CLDN18 claudin 18
COL7A1 collagen, type VII, alpha 1
COL8A2 collagen, type VIII, alpha 2
CTIF CBP80/20-dependent translation initiation factor
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCN decorin
DCT dopachrome tautomerase
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNALI1 dynein, axonemal, light intermediate chain 1
DRD5 dopamine receptor D5
ECEL1 endothelin converting enzyme-like 1
EMID1 EMI domain containing 1
FBLN1 fibulin 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGF4 fibroblast growth factor 4
FLOT1 flotillin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FSHB follicle stimulating hormone, beta polypeptide
FXYD2 FXYD domain containing ion transport regulator 2
FZD1 frizzled class receptor 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GPR137 G protein-coupled receptor 137
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIP2 glutamate receptor interacting protein 2
GSTA4 glutathione S-transferase alpha 4
HCG4 HLA complex group 4 (non-protein coding)
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA11 homeobox A11
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ING2 inhibitor of growth family, member 2
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KRT8 keratin 8, type II
LDLR low density lipoprotein receptor
LOC100127972 uncharacterized LOC100127972
LOX lysyl oxidase
LYZL6 lysozyme-like 6
MAOA monoamine oxidase A
MMP27 matrix metallopeptidase 27
NF1 neurofibromin 1
NPR3 natriuretic peptide receptor 3
NPY neuropeptide Y
NRG2 neuregulin 2
OXCT2 3-oxoacid CoA transferase 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDLIM3 PDZ and LIM domain 3
PDZD2 PDZ domain containing 2
PLA2G2E phospholipase A2, group IIE
PMEL premelanosome protein
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PRAMEF10 PRAME family member 10
PRODH2 proline dehydrogenase (oxidase) 2
PSG6 pregnancy specific beta-1-glycoprotein 6
RABGAP1L RAB GTPase activating protein 1-like
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAP2B RAP2B, member of RAS oncogene family
RBM12B RNA binding motif protein 12B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND1 Rho family GTPase 1
RUNX1 runt-related transcription factor 1
SAA3P serum amyloid A3 pseudogene
SBNO1 strawberry notch homolog 1 (Drosophila)
SGK2 serum/glucocorticoid regulated kinase 2
SKIL SKI-like proto-oncogene
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SOX10 SRY (sex determining region Y)-box 10
SPDEF SAM pointed domain containing ETS transcription factor
SPEG SPEG complex locus
TBXA2R thromboxane A2 receptor
TIMP3 TIMP metallopeptidase inhibitor 3
TMCC2 transmembrane and coiled-coil domain family 2
TSKS testis-specific serine kinase substrate
TTLL5 tubulin tyrosine ligase-like family member 5
UBE2I ubiquitin-conjugating enzyme E2I
UBE3A ubiquitin protein ligase E3A
WSCD1 WSC domain containing 1
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACAD10 acyl-CoA dehydrogenase family, member 10
AHSP alpha hemoglobin stabilizing protein
AIRE autoimmune regulator
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BCAS1 breast carcinoma amplified sequence 1
CALML5 calmodulin-like 5
CD1A CD1a molecule
CEND1 cell cycle exit and neuronal differentiation 1
CFAP70 cilia and flagella associated protein 70
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCN6 chloride channel, voltage-sensitive 6
CNPY4 canopy FGF signaling regulator 4
CNTFR ciliary neurotrophic factor receptor
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPNE7 copine VII
CRABP1 cellular retinoic acid binding protein 1
CTRL chymotrypsin-like
DEPDC5 DEP domain containing 5
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DIXDC1 DIX domain containing 1
DNAL4 dynein, axonemal, light chain 4
DYSF dysferlin
EDAR ectodysplasin A receptor
EGFL7 EGF-like-domain, multiple 7
EHBP1L1 EH domain binding protein 1-like 1
ERN2 endoplasmic reticulum to nucleus signaling 2
F2R coagulation factor II (thrombin) receptor
FAM46C family with sequence similarity 46, member C
FANCE Fanconi anemia, complementation group E
FGF13 fibroblast growth factor 13
FOXN2 forkhead box N2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAMT guanidinoacetate N-methyltransferase
GFI1 growth factor independent 1 transcription repressor
GPR143 G protein-coupled receptor 143
GPR182 G protein-coupled receptor 182
GRTP1 growth hormone regulated TBC protein 1
GSTTP1 glutathione S-transferase theta pseudogene 1
GUSBP3 glucuronidase, beta pseudogene 3
HCAR3 hydroxycarboxylic acid receptor 3
HDAC7 histone deacetylase 7
HIST1H4E histone cluster 1, H4e
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXD11 homeobox D11
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KRT15 keratin 15, type I
LOXL3 lysyl oxidase-like 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPK10 mitogen-activated protein kinase 10
MT1HL1 metallothionein 1H-like 1
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NABP2 nucleic acid binding protein 2
NDRG1 N-myc downstream regulated 1
NYNRIN NYN domain and retroviral integrase containing
OLFML2A olfactomedin-like 2A
ONECUT1 one cut homeobox 1
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OVOL1 ovo-like zinc finger 1
PCDHA5 protocadherin alpha 5
PLCD1 phospholipase C, delta 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLK3 polo-like kinase 3
PODNL1 podocan-like 1
POLL polymerase (DNA directed), lambda
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRODH proline dehydrogenase (oxidase) 1
PRR4 proline rich 4 (lacrimal)
PVRL3 poliovirus receptor-related 3
QPCTL glutaminyl-peptide cyclotransferase-like
RAB36 RAB36, member RAS oncogene family
RAB40AL RAB40A, member RAS oncogene family-like
RNF122 ring finger protein 122
RNF39 ring finger protein 39
RPH3A rabphilin 3A
RPL23AP32 ribosomal protein L23a pseudogene 32
S100A2 S100 calcium binding protein A2
SDS serine dehydratase
SLPI secretory leukocyte peptidase inhibitor
SNTA1 syntrophin, alpha 1
SOX12 SRY (sex determining region Y)-box 12
SSTR4 somatostatin receptor 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TARP TCR gamma alternate reading frame protein
TBKBP1 TBK1 binding protein 1
TLN1 talin 1
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBTD1 ubiquitin domain containing 1
UPP1 uridine phosphorylase 1
VAX2 ventral anterior homeobox 2
VN1R1 vomeronasal 1 receptor 1
ZNRD1-AS1 ZNRD1 antisense RNA 1