metoclopramide-3728 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the metoclopramide-3728 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACE angiotensin I converting enzyme
ACTN2 actinin, alpha 2
ADD2 adducin 2 (beta)
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARC activity-regulated cytoskeleton-associated protein
ARHGAP28 Rho GTPase activating protein 28
ARTN artemin
BCAS1 breast carcinoma amplified sequence 1
BTG3 BTG family, member 3
CD40 CD40 molecule, TNF receptor superfamily member 5
CDO1 cysteine dioxygenase type 1
CEP152 centrosomal protein 152kDa
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL2A1 collagen, type II, alpha 1
COL8A2 collagen, type VIII, alpha 2
COPE coatomer protein complex, subunit epsilon
CRHR2 corticotropin releasing hormone receptor 2
DEFA4 defensin, alpha 4, corticostatin
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKFZP434C153 DKFZP434C153 protein
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOHH deoxyhypusine hydroxylase/monooxygenase
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPF1 D4, zinc and double PHD fingers family 1
DST dystonin
EGFR epidermal growth factor receptor
EMC3 ER membrane protein complex subunit 3
EXOG endo/exonuclease (5'-3'), endonuclease G-like
EXOSC1 exosome component 1
FABP3 fatty acid binding protein 3, muscle and heart
FBXO31 F-box protein 31
FBXO40 F-box protein 40
FCF1 FCF1 rRNA-processing protein
FGF6 fibroblast growth factor 6
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
HIC2 hypermethylated in cancer 2
IL20RA interleukin 20 receptor, alpha
IL32 interleukin 32
IRF8 interferon regulatory factor 8
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD14 potassium channel tetramerization domain containing 14
KIAA0319L KIAA0319-like
KIAA1109 KIAA1109
KRT17 keratin 17, type I
LARP4B La ribonucleoprotein domain family, member 4B
LTBP4 latent transforming growth factor beta binding protein 4
MIP major intrinsic protein of lens fiber
MMP11 matrix metallopeptidase 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MNMIP1 manchette microtubule inner protein 1
MST1 macrophage stimulating 1
MUC13 mucin 13, cell surface associated
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTM neurotrimin
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OVOL1 ovo-like zinc finger 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PDE5A phosphodiesterase 5A, cGMP-specific
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLK3 polo-like kinase 3
PLXND1 plexin D1
PRDM2 PR domain containing 2, with ZNF domain
PRKCE protein kinase C, epsilon
PRUNE2 prune homolog 2 (Drosophila)
RAB6B RAB6B, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RANBP1 RAN binding protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RBM34 RNA binding motif protein 34
REEP2 receptor accessory protein 2
RGS4 regulator of G-protein signaling 4
RNF6 ring finger protein (C3H2C3 type) 6
RPH3A rabphilin 3A
RUNX1 runt-related transcription factor 1
RXRB retinoid X receptor, beta
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SHANK1 SH3 and multiple ankyrin repeat domains 1
SMAD6 SMAD family member 6
SYNJ1 synaptojanin 1
TET3 tet methylcytosine dioxygenase 3
TJP3 tight junction protein 3
TLR2 toll-like receptor 2
TMPRSS15 transmembrane protease, serine 15
TPP1 tripeptidyl peptidase I
TUBA3C tubulin, alpha 3c
UBR4 ubiquitin protein ligase E3 component n-recognin 4
USP53 ubiquitin specific peptidase 53
VPRBP Vpr (HIV-1) binding protein
XYLB xylulokinase homolog (H. influenzae)
YY2 YY2 transcription factor
ZFAND5 zinc finger, AN1-type domain 5
ZNF287 zinc finger protein 287
ZNF506 zinc finger protein 506

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
AHSG alpha-2-HS-glycoprotein
ALPK1 alpha-kinase 1
AMT aminomethyltransferase
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
APOL6 apolipoprotein L, 6
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX4 armadillo repeat containing, X-linked 4
ARPIN actin-related protein 2/3 complex inhibitor
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BIRC7 baculoviral IAP repeat containing 7
BMP15 bone morphogenetic protein 15
BMP4 bone morphogenetic protein 4
C1QTNF3 C1q and tumor necrosis factor related protein 3
CADPS2 Ca++-dependent secretion activator 2
CAMK4 calcium/calmodulin-dependent protein kinase IV
CDH19 cadherin 19, type 2
CDK6 cyclin-dependent kinase 6
CFAP69 cilia and flagella associated protein 69
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCA1 chloride channel accessory 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CORO1A coronin, actin binding protein, 1A
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPZ carboxypeptidase Z
DSPP dentin sialophosphoprotein
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EGFL7 EGF-like-domain, multiple 7
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EXD3 exonuclease 3'-5' domain containing 3
FRMD1 FERM domain containing 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GAS8 growth arrest-specific 8
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR85 G protein-coupled receptor 85
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRTP1 growth hormone regulated TBC protein 1
HIST1H1D histone cluster 1, H1d
HIST1H2BB histone cluster 1, H2bb
HIST1H2BM histone cluster 1, H2bm
HOXA6 homeobox A6
HSF2BP heat shock transcription factor 2 binding protein
IFNA14 interferon, alpha 14
INCENP inner centromere protein antigens 135/155kDa
IRAK4 interleukin-1 receptor-associated kinase 4
KLHL25 kelch-like family member 25
LOC100286895 cell division cycle 27 homolog pseudogene
LOC729164 hCG1732469
MAP2 microtubule-associated protein 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED31 mediator complex subunit 31
MEFV Mediterranean fever
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MLYCD malonyl-CoA decarboxylase
MMP2 matrix metallopeptidase 2
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYOZ3 myozenin 3
NBEAL2 neurobeachin-like 2
NPFFR1 neuropeptide FF receptor 1
NPHP1 nephronophthisis 1 (juvenile)
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5M 5',3'-nucleotidase, mitochondrial
PACS1 phosphofurin acidic cluster sorting protein 1
PODNL1 podocan-like 1
PODXL2 podocalyxin-like 2
POLL polymerase (DNA directed), lambda
PRAMEF10 PRAME family member 10
PRAMEF11 PRAME family member 11
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS53 protease, serine, 53
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RNF39 ring finger protein 39
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S100A3 S100 calcium binding protein A3
SCD5 stearoyl-CoA desaturase 5
SETD1A SET domain containing 1A
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMO smoothened, frizzled class receptor
SP1 Sp1 transcription factor
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAGLN3 transgelin 3
TESPA1 thymocyte expressed, positive selection associated 1
THRB thyroid hormone receptor, beta
TIGD6 tigger transposable element derived 6
TRAC T cell receptor alpha constant
TSNAXIP1 translin-associated factor X interacting protein 1
TUBB2B tubulin, beta 2B class IIb
USP27X ubiquitin specific peptidase 27, X-linked
WDR33 WD repeat domain 33
WDR62 WD repeat domain 62
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF428 zinc finger protein 428
ZNF749 zinc finger protein 749