metoclopramide-4285 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the metoclopramide-4285 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACVR1B activin A receptor, type IB
AHSG alpha-2-HS-glycoprotein
AMPD3 adenosine monophosphate deaminase 3
ANGPTL2 angiopoietin-like 2
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOE apolipoprotein E
ARMCX4 armadillo repeat containing, X-linked 4
ATN1 atrophin 1
BLZF1 basic leucine zipper nuclear factor 1
C3AR1 complement component 3a receptor 1
C7ORF69 chromosome 7 open reading frame 69
CAMK4 calcium/calmodulin-dependent protein kinase IV
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKL5 cyclin-dependent kinase-like 5
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
COMT catechol-O-methyltransferase
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTSZ cathepsin Z
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DBP D site of albumin promoter (albumin D-box) binding protein
DCAF7 DDB1 and CUL4 associated factor 7
DIO3 deiodinase, iodothyronine, type III
DMRT1 doublesex and mab-3 related transcription factor 1
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EPHA5 EPH receptor A5
FAM149B1 family with sequence similarity 149, member B1
FLT1 fms-related tyrosine kinase 1
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GREB1L growth regulation by estrogen in breast cancer-like
GRM1 glutamate receptor, metabotropic 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HBB hemoglobin, beta
HHLA1 HERV-H LTR-associating 1
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H3J histone cluster 1, H3j
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXB7 homeobox B7
HRG histidine-rich glycoprotein
HTATSF1 HIV-1 Tat specific factor 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IFFO1 intermediate filament family orphan 1
IL5RA interleukin 5 receptor, alpha
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCTD17 potassium channel tetramerization domain containing 17
LARP4B La ribonucleoprotein domain family, member 4B
LCT lactase
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LIMD1 LIM domains containing 1
LINC00312 long intergenic non-protein coding RNA 312
LPP LIM domain containing preferred translocation partner in lipoma
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP4 microtubule-associated protein 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED16 mediator complex subunit 16
MED18 mediator complex subunit 18
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MORN1 MORN repeat containing 1
NDRG2 NDRG family member 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPY6R neuropeptide Y receptor Y6 (pseudogene)
PDE10A phosphodiesterase 10A
PDE4D phosphodiesterase 4D, cAMP-specific
PKP4 plakophilin 4
PPIA peptidylprolyl isomerase A (cyclophilin A)
PTGIS prostaglandin I2 (prostacyclin) synthase
PVT1 Pvt1 oncogene (non-protein coding)
RAB6A RAB6A, member RAS oncogene family
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RIBC2 RIB43A domain with coiled-coils 2
RNGTT RNA guanylyltransferase and 5'-phosphatase
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SFTPB surfactant protein B
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SMAD5 SMAD family member 5
SUGP1 SURP and G patch domain containing 1
SULT4A1 sulfotransferase family 4A, member 1
TADA2A transcriptional adaptor 2A
TEF thyrotrophic embryonic factor
TEX15 testis expressed 15
TLL1 tolloid-like 1
TMEM180 transmembrane protein 180
TMPO thymopoietin
TMPRSS6 transmembrane protease, serine 6
TP53I11 tumor protein p53 inducible protein 11
UTF1 undifferentiated embryonic cell transcription factor 1
VSIG4 V-set and immunoglobulin domain containing 4
ZC3H11A zinc finger CCCH-type containing 11A
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFPL1 zinc finger protein-like 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF749 zinc finger protein 749

decreased expression

Symbol Name
AEN apoptosis enhancing nuclease
ASCC2 activating signal cointegrator 1 complex subunit 2
AXIN1 axin 1
BTBD2 BTB (POZ) domain containing 2
C17ORF53 chromosome 17 open reading frame 53
C1RL complement component 1, r subcomponent-like
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPN15 calpain 15
CBX8 chromobox homolog 8
CCDC106 coiled-coil domain containing 106
CCNO cyclin O
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNN2 calponin 2
CRY2 cryptochrome circadian clock 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DFNB31 deafness, autosomal recessive 31
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB1 ephrin-B1
ELOVL4 ELOVL fatty acid elongase 4
FAM131B family with sequence similarity 131, member B
FAM53C family with sequence similarity 53, member C
FAT4 FAT atypical cadherin 4
FGF23 fibroblast growth factor 23
FKBP10 FK506 binding protein 10, 65 kDa
FMO4 flavin containing monooxygenase 4
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAREM GRB2 associated, regulator of MAPK1
GATAD2A GATA zinc finger domain containing 2A
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HIST1H1T histone cluster 1, H1t
HIST1H3G histone cluster 1, H3g
HOXC13 homeobox C13
HOXC4 homeobox C4
HSPA1L heat shock 70kDa protein 1-like
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA17 interferon, alpha 17
IL17RA interleukin 17 receptor A
IL24 interleukin 24
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0319L KIAA0319-like
KIAA0513 KIAA0513
KIAA1107 KIAA1107
KIFC1 kinesin family member C1
KLHL26 kelch-like family member 26
LMNB1 lamin B1
LOC257152 uncharacterized LOC257152
LRP4 low density lipoprotein receptor-related protein 4
LRRC61 leucine rich repeat containing 61
LYPLA2P1 lysophospholipase II pseudogene 1
MAP1S microtubule-associated protein 1S
MFGE8 milk fat globule-EGF factor 8 protein
MNX1 motor neuron and pancreas homeobox 1
MOGS mannosyl-oligosaccharide glucosidase
MRPL28 mitochondrial ribosomal protein L28
MRPL52 mitochondrial ribosomal protein L52
MXD3 MAX dimerization protein 3
MYO1D myosin ID
NDRG4 NDRG family member 4
NOTCH1 notch 1
NPM3 nucleophosmin/nucleoplasmin 3
NTSR1 neurotensin receptor 1 (high affinity)
ORAI3 ORAI calcium release-activated calcium modulator 3
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PALM paralemmin
PGPEP1 pyroglutamyl-peptidase I
PHACTR4 phosphatase and actin regulator 4
POLL polymerase (DNA directed), lambda
POR P450 (cytochrome) oxidoreductase
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RGS17 regulator of G-protein signaling 17
RHOBTB2 Rho-related BTB domain containing 2
RNF126P1 ring finger protein 126 pseudogene 1
RUSC2 RUN and SH3 domain containing 2
SDC3 syndecan 3
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SPIDR scaffolding protein involved in DNA repair
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TESK2 testis-specific kinase 2
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAF2 TNF receptor-associated factor 2
TSPYL2 TSPY-like 2
UBOX5 U-box domain containing 5
UNC119 unc-119 homolog (C. elegans)
WDR25 WD repeat domain 25
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YY2 YY2 transcription factor
ZC2HC1C zinc finger, C2HC-type containing 1C
ZHX2 zinc fingers and homeoboxes 2
ZNF37BP zinc finger protein 37B, pseudogene
ZNF573 zinc finger protein 573
ZNF76 zinc finger protein 76
ZYX zyxin