metoprolol-2543 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the metoprolol-2543 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABLIM1 actin binding LIM protein 1
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACVRL1 activin A receptor type II-like 1
AGXT alanine-glyoxylate aminotransferase
ALDOB aldolase B, fructose-bisphosphate
AMH anti-Mullerian hormone
ANO2 anoctamin 2, calcium activated chloride channel
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC7 baculoviral IAP repeat containing 7
C1R complement component 1, r subcomponent
C8A complement component 8, alpha polypeptide
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CASS4 Cas scaffolding protein family member 4
CD3D CD3d molecule, delta (CD3-TCR complex)
CD6 CD6 molecule
CEMP1 cementum protein 1
COL7A1 collagen, type VII, alpha 1
CRH corticotropin releasing hormone
CXCR6 chemokine (C-X-C motif) receptor 6
CYHR1 cysteine/histidine-rich 1
DOCK9 dedicator of cytokinesis 9
DPP4 dipeptidyl-peptidase 4
EGOT eosinophil granule ontogeny transcript (non-protein coding)
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
FAM149B1 family with sequence similarity 149, member B1
FBLN1 fibulin 1
FBXO21 F-box protein 21
FGFR2 fibroblast growth factor receptor 2
FLJ11292
FOXE1 forkhead box E1
GJA8 gap junction protein, alpha 8, 50kDa
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRM4 glutamate receptor, metabotropic 4
HAB1 B1 for mucin
HIC1 hypermethylated in cancer 1
HOXC4 homeobox C4
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KCTD17 potassium channel tetramerization domain containing 17
KIAA1107 KIAA1107
KNG1 kininogen 1
LAMA4 laminin, alpha 4
LAMB2 laminin, beta 2 (laminin S)
MAB21L2 mab-21-like 2 (C. elegans)
MBD2 methyl-CpG binding domain protein 2
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MDFI MyoD family inhibitor
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MNMIP1 manchette microtubule inner protein 1
MOB3B MOB kinase activator 3B
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MPZL2 myelin protein zero-like 2
MSRB2 methionine sulfoxide reductase B2
MYO15B myosin XVB
NPR3 natriuretic peptide receptor 3
NRAP nebulin-related anchoring protein
PACRG PARK2 co-regulated
PADI1 peptidyl arginine deiminase, type I
PADI4 peptidyl arginine deiminase, type IV
PAX3 paired box 3
PDGFRL platelet-derived growth factor receptor-like
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PLSCR2 phospholipid scramblase 2
POU6F2 POU class 6 homeobox 2
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRB3 proline-rich protein BstNI subfamily 3
PRELP proline/arginine-rich end leucine-rich repeat protein
PRM2 protamine 2
PRO2964 uncharacterized protein PRO2964
PTMS parathymosin
RAP1GAP RAP1 GTPase activating protein
RARG retinoic acid receptor, gamma
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REC8 REC8 meiotic recombination protein
S100A5 S100 calcium binding protein A5
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SRPK3 SRSF protein kinase 3
STAB2 stabilin 2
STMN2 stathmin 2
STMN4 stathmin-like 4
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TK2 thymidine kinase 2, mitochondrial
TNK1 tyrosine kinase, non-receptor, 1
TPMT thiopurine S-methyltransferase
TRAT1 T cell receptor associated transmembrane adaptor 1
VCAM1 vascular cell adhesion molecule 1
WNT7A wingless-type MMTV integration site family, member 7A
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
APOLD1 apolipoprotein L domain containing 1
ARHGAP11A Rho GTPase activating protein 11A
ARMC7 armadillo repeat containing 7
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
AXIN1 axin 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAG2 BCL2-associated athanogene 2
BMI1 BMI1 proto-oncogene, polycomb ring finger
C2CD2 C2 calcium-dependent domain containing 2
C8ORF44 chromosome 8 open reading frame 44
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC6 coiled-coil domain containing 6
CEP70 centrosomal protein 70kDa
CSNK1G3 casein kinase 1, gamma 3
DDHD2 DDHD domain containing 2
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DOLK dolichol kinase
DTX4 deltex 4, E3 ubiquitin ligase
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
ERMAP erythroblast membrane-associated protein (Scianna blood group)
F8 coagulation factor VIII, procoagulant component
FAM172A family with sequence similarity 172, member A
FASTKD5 FAST kinase domains 5
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GPATCH3 G patch domain containing 3
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HIST1H2BE histone cluster 1, H2be
HSPA1L heat shock 70kDa protein 1-like
HYAL3 hyaluronoglucosaminidase 3
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IMPAD1 inositol monophosphatase domain containing 1
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIN Kin17 DNA and RNA binding protein
KPNA4 karyopherin alpha 4 (importin alpha 3)
LINC00339 long intergenic non-protein coding RNA 339
MCRS1 microspherule protein 1
MECR mitochondrial trans-2-enoyl-CoA reductase
MEST mesoderm specific transcript
METTL2B methyltransferase like 2B
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYL5 myosin, light chain 5, regulatory
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOD1 nucleotide-binding oligomerization domain containing 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAQR3 progestin and adipoQ receptor family member III
PDZD7 PDZ domain containing 7
PFKM phosphofructokinase, muscle
PIR pirin (iron-binding nuclear protein)
PMCH pro-melanin-concentrating hormone
POLM polymerase (DNA directed), mu
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRR4 proline rich 4 (lacrimal)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSAT1 phosphoserine aminotransferase 1
QTRT1 queuine tRNA-ribosyltransferase 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SERINC5 serine incorporator 5
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SHPK sedoheptulokinase
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNX16 sorting nexin 16
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSFA2 sperm specific antigen 2
TBC1D17 TBC1 domain family, member 17
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM9SF4 transmembrane 9 superfamily protein member 4
TMEM115 transmembrane protein 115
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPV2 transient receptor potential cation channel, subfamily V, member 2
UBL4A ubiquitin-like 4A
WBSCR16 Williams-Beuren syndrome chromosome region 16
XPC xeroderma pigmentosum, complementation group C
ZFYVE21 zinc finger, FYVE domain containing 21
ZNF232 zinc finger protein 232
ZNF350 zinc finger protein 350
ZNF37BP zinc finger protein 37B, pseudogene
ZNF574 zinc finger protein 574
ZNHIT2 zinc finger, HIT-type containing 2