metyrapone-3070 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the metyrapone-3070 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACVR1B activin A receptor, type IB
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOB aldolase B, fructose-bisphosphate
ALK anaplastic lymphoma receptor tyrosine kinase
ANKEF1 ankyrin repeat and EF-hand domain containing 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATF7 activating transcription factor 7
ATP7B ATPase, Cu++ transporting, beta polypeptide
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAIAP2 BAI1-associated protein 2
CARD10 caspase recruitment domain family, member 10
CARTPT CART prepropeptide
CCKAR cholecystokinin A receptor
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CDC14B cell division cycle 14B
CDR2L cerebellar degeneration-related protein 2-like
CEND1 cell cycle exit and neuronal differentiation 1
CLEC4M C-type lectin domain family 4, member M
COL14A1 collagen, type XIV, alpha 1
DGAT1 diacylglycerol O-acyltransferase 1
DHODH dihydroorotate dehydrogenase (quinone)
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DOCK6 dedicator of cytokinesis 6
DPEP2 dipeptidase 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EDDM3B epididymal protein 3B
EFNA3 ephrin-A3
EGFR epidermal growth factor receptor
FBXL7 F-box and leucine-rich repeat protein 7
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FRMD1 FERM domain containing 1
G6PC3 glucose 6 phosphatase, catalytic, 3
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GHRHR growth hormone releasing hormone receptor
GLCE glucuronic acid epimerase
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HOXB5 homeobox B5
IGFBP4 insulin-like growth factor binding protein 4
INA internexin neuronal intermediate filament protein, alpha
KIAA0513 KIAA0513
KIAA1456 KIAA1456
KIF13B kinesin family member 13B
KIF25-AS1 KIF25 antisense RNA 1
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KLF12 Kruppel-like factor 12
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MAGIX MAGI family member, X-linked
MAOA monoamine oxidase A
MAP4 microtubule-associated protein 4
MASP2 mannan-binding lectin serine peptidase 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO3A myosin IIIA
NCAM1 neural cell adhesion molecule 1
NCKIPSD NCK interacting protein with SH3 domain
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
OPRM1 opioid receptor, mu 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PCDHGB6 protocadherin gamma subfamily B, 6
PCIF1 PDX1 C-terminal inhibiting factor 1
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLA2G3 phospholipase A2, group III
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
POFUT1 protein O-fucosyltransferase 1
POLM polymerase (DNA directed), mu
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RBBP4 retinoblastoma binding protein 4
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RTEL1 regulator of telomere elongation helicase 1
SHB Src homology 2 domain containing adaptor protein B
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOCS7 suppressor of cytokine signaling 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STS steroid sulfatase (microsomal), isozyme S
TBXA2R thromboxane A2 receptor
THBS1 thrombospondin 1
TJAP1 tight junction associated protein 1 (peripheral)
TPSAB1 tryptase alpha/beta 1
TRD T cell receptor delta locus
TRIM3 tripartite motif containing 3
TSC22D2 TSC22 domain family, member 2
UBXN1 UBX domain protein 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF185 zinc finger protein 185 (LIM domain)
ZNF440 zinc finger protein 440
ZNF444 zinc finger protein 444
ZNF749 zinc finger protein 749
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ADORA3 adenosine A3 receptor
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALPK1 alpha-kinase 1
ANKRD36 ankyrin repeat domain 36
AOAH acyloxyacyl hydrolase (neutrophil)
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAG4 BCL2-associated athanogene 4
C14ORF93 chromosome 14 open reading frame 93
C16ORF59 chromosome 16 open reading frame 59
C1QTNF3 C1q and tumor necrosis factor related protein 3
C5AR1 complement component 5a receptor 1
C5ORF45 chromosome 5 open reading frame 45
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK6 cyclin-dependent kinase 6
CECR1 cat eye syndrome chromosome region, candidate 1
CEP295 centrosomal protein 295kDa
CIDEB cell death-inducing DFFA-like effector b
CNR2 cannabinoid receptor 2 (macrophage)
CXORF56 chromosome X open reading frame 56
DNM3 dynamin 3
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ELP6 elongator acetyltransferase complex subunit 6
FAM188A family with sequence similarity 188, member A
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FKBP9 FK506 binding protein 9, 63 kDa
FLJ21369 uncharacterized protein FLJ21369
FOXO4 forkhead box O4
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GPR19 G protein-coupled receptor 19
GPR27 G protein-coupled receptor 27
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HHLA3 HERV-H LTR-associating 3
HIST1H1B histone cluster 1, H1b
HMGA2 high mobility group AT-hook 2
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA4L heat shock 70kDa protein 4-like
IFI6 interferon, alpha-inducible protein 6
IGLV1-44 immunoglobulin lambda variable 1-44
IKZF5 IKAROS family zinc finger 5 (Pegasus)
JUNB jun B proto-oncogene
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KAT2A K(lysine) acetyltransferase 2A
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0319L KIAA0319-like
KIF24 kinesin family member 24
LIN7A lin-7 homolog A (C. elegans)
LNPEP leucyl/cystinyl aminopeptidase
LOC157562 uncharacterized LOC157562
MAPK12 mitogen-activated protein kinase 12
MB myoglobin
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MPI mannose phosphate isomerase
NABP2 nucleic acid binding protein 2
NACA2 nascent polypeptide-associated complex alpha subunit 2
NARFL nuclear prelamin A recognition factor-like
NIPAL2 NIPA-like domain containing 2
NOL6 nucleolar protein 6 (RNA-associated)
NUBP2 nucleotide binding protein 2
ODF2 outer dense fiber of sperm tails 2
PARP11 poly (ADP-ribose) polymerase family, member 11
PGP phosphoglycolate phosphatase
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G12A phospholipase A2, group XIIA
PLS1 plastin 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RFXAP regulatory factor X-associated protein
RIN1 Ras and Rab interactor 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
RWDD2A RWD domain containing 2A
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SETD8 SET domain containing (lysine methyltransferase) 8
SLC16A4 solute carrier family 16, member 4
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
ST7L suppression of tumorigenicity 7 like
STBD1 starch binding domain 1
TEX264 testis expressed 264
TMCO6 transmembrane and coiled-coil domains 6
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPS1 trichorhinophalangeal syndrome I
TRPV1 transient receptor potential cation channel, subfamily V, member 1
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
ZNF480 zinc finger protein 480
ZNF770 zinc finger protein 770
ZNF862 zinc finger protein 862