metyrapone-5667 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the metyrapone-5667 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ADRB1 adrenoceptor beta 1
ADRBK1 adrenergic, beta, receptor kinase 1
AMELX amelogenin, X-linked
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOLD1 apolipoprotein L domain containing 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BAX BCL2-associated X protein
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BLNK B-cell linker
BTG2 BTG family, member 2
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCNK cyclin K
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP250 centrosomal protein 250kDa
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLCA2 chloride channel accessory 2
CNTN5 contactin 5
COL10A1 collagen, type X, alpha 1
COL9A3 collagen, type IX, alpha 3
CORO2B coronin, actin binding protein, 2B
CSF1 colony stimulating factor 1 (macrophage)
CUL7 cullin 7
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DMP1 dentin matrix acidic phosphoprotein 1
DPYSL4 dihydropyrimidinase-like 4
DSCAM Down syndrome cell adhesion molecule
ERN1 endoplasmic reticulum to nucleus signaling 1
FAS Fas cell surface death receptor
FBXO2 F-box protein 2
FCMR Fc fragment of IgM receptor
FHL1 four and a half LIM domains 1
FLJ11292
FOXG1 forkhead box G1
GADD45A growth arrest and DNA-damage-inducible, alpha
GH1 growth hormone 1
GK glycerol kinase
GLRA2 glycine receptor, alpha 2
GPR21 G protein-coupled receptor 21
GRIP2 glutamate receptor interacting protein 2
HDAC9 histone deacetylase 9
HGD homogentisate 1,2-dioxygenase
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
HRASLS2 HRAS-like suppressor 2
IDS iduronate 2-sulfatase
IL1B interleukin 1, beta
ITGB7 integrin, beta 7
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KLK13 kallikrein-related peptidase 13
LIMK2 LIM domain kinase 2
LINC00597 long intergenic non-protein coding RNA 597
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC441601 septin 7 pseudogene
LOXL3 lysyl oxidase-like 3
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARK4 MAP/microtubule affinity-regulating kinase 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
NF1 neurofibromin 1
NHLH2 nescient helix loop helix 2
OLIG2 oligodendrocyte lineage transcription factor 2
PADI3 peptidyl arginine deiminase, type III
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHGA8 protocadherin gamma subfamily A, 8
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G5 phospholipase A2, group V
PLCD1 phospholipase C, delta 1
PLXNB3 plexin B3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRDM11 PR domain containing 11
PRLR prolactin receptor
PSG1 pregnancy specific beta-1-glycoprotein 1
PSG3 pregnancy specific beta-1-glycoprotein 3
PSG6 pregnancy specific beta-1-glycoprotein 6
RAI2 retinoic acid induced 2
RASA3 RAS p21 protein activator 3
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SORBS1 sorbin and SH3 domain containing 1
SYNGR1 synaptogyrin 1
SYNPO synaptopodin
SYT12 synaptotagmin XII
TECTA tectorin alpha
TEX41 testis expressed 41 (non-protein coding)
TLDC1 TBC/LysM-associated domain containing 1
TMPRSS6 transmembrane protease, serine 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBB2B tubulin, beta 2B class IIb
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VNN2 vanin 2
ZBTB44 zinc finger and BTB domain containing 44
ZNF76 zinc finger protein 76
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARMC6 armadillo repeat containing 6
ARRB1 arrestin, beta 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP10D ATPase, class V, type 10D
BAG4 BCL2-associated athanogene 4
BCL9 B-cell CLL/lymphoma 9
BMP4 bone morphogenetic protein 4
C21ORF91 chromosome 21 open reading frame 91
C2ORF68 chromosome 2 open reading frame 68
CAMKMT calmodulin-lysine N-methyltransferase
CAMTA2 calmodulin binding transcription activator 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNE2 cyclin E2
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDHR2 cadherin-related family member 2
CDT1 chromatin licensing and DNA replication factor 1
CEP162 centrosomal protein 162kDa
CGA glycoprotein hormones, alpha polypeptide
CLSPN claspin
CRABP1 cellular retinoic acid binding protein 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DGKE diacylglycerol kinase, epsilon 64kDa
E2F8 E2F transcription factor 8
EDAR ectodysplasin A receptor
EFNA3 ephrin-A3
FAM198B family with sequence similarity 198, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO5 F-box protein 5
FLRT3 fibronectin leucine rich transmembrane protein 3
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H2BJ histone cluster 1, H2bj
HOXD11 homeobox D11
JMJD4 jumonji domain containing 4
KLF7 Kruppel-like factor 7 (ubiquitous)
LAMA3 laminin, alpha 3
LHX1 LIM homeobox 1
LOC257152 uncharacterized LOC257152
LRRC42 leucine rich repeat containing 42
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MATK megakaryocyte-associated tyrosine kinase
MDM4 MDM4, p53 regulator
METTL16 methyltransferase like 16
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
NEK11 NIMA-related kinase 11
NES nestin
NFE2L3 nuclear factor, erythroid 2-like 3
NME6 NME/NM23 nucleoside diphosphate kinase 6
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5DC3 5'-nucleotidase domain containing 3
OSMR oncostatin M receptor
PACS1 phosphofurin acidic cluster sorting protein 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PRICKLE3 prickle homolog 3 (Drosophila)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFTN1 raftlin, lipid raft linker 1
RIBC2 RIB43A domain with coiled-coils 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPH3AL rabphilin 3A-like (without C2 domains)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
S100A9 S100 calcium binding protein A9
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC26A6 solute carrier family 26 (anion exchanger), member 6
STAG3 stromal antigen 3
STIM1 stromal interaction molecule 1
TBR1 T-box, brain, 1
TET3 tet methylcytosine dioxygenase 3
TMEM19 transmembrane protein 19
TMEM53 transmembrane protein 53
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRAF2 TNF receptor-associated factor 2
TREM1 triggering receptor expressed on myeloid cells 1
TRIM25 tripartite motif containing 25
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TWISTNB TWIST neighbor
VEZT vezatin, adherens junctions transmembrane protein
VIM vimentin
WDR18 WD repeat domain 18
WDR33 WD repeat domain 33
WDR4 WD repeat domain 4
ZBED1 zinc finger, BED-type containing 1
ZC3H3 zinc finger CCCH-type containing 3
ZNF165 zinc finger protein 165
ZNF219 zinc finger protein 219
ZNF510 zinc finger protein 510
ZNF804A zinc finger protein 804A