mevalolactone-2718 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the mevalolactone-2718 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABLIM1 actin binding LIM protein 1
ACSM1 acyl-CoA synthetase medium-chain family member 1
ADAM22 ADAM metallopeptidase domain 22
ADRBK1 adrenergic, beta, receptor kinase 1
AGER advanced glycosylation end product-specific receptor
ALOXE3 arachidonate lipoxygenase 3
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
ARHGAP35 Rho GTPase activating protein 35
ATP10A ATPase, class V, type 10A
BDNF brain-derived neurotrophic factor
C11ORF63 chromosome 11 open reading frame 63
C8A complement component 8, alpha polypeptide
CAV3 caveolin 3
CCKAR cholecystokinin A receptor
CCL19 chemokine (C-C motif) ligand 19
CCL27 chemokine (C-C motif) ligand 27
CD79B CD79b molecule, immunoglobulin-associated beta
CDON cell adhesion associated, oncogene regulated
CIITA class II, major histocompatibility complex, transactivator
COL14A1 collagen, type XIV, alpha 1
DMP1 dentin matrix acidic phosphoprotein 1
DOCK5 dedicator of cytokinesis 5
EDN3 endothelin 3
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM13C family with sequence similarity 13, member C
FBXL7 F-box and leucine-rich repeat protein 7
FCAR Fc fragment of IgA receptor
FGFR2 fibroblast growth factor receptor 2
FOSL2 FOS-like antigen 2
FOXC1 forkhead box C1
FRMPD1 FERM and PDZ domain containing 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FXYD7 FXYD domain containing ion transport regulator 7
GJB4 gap junction protein, beta 4, 30.3kDa
GK2 glycerol kinase 2
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPR137 G protein-coupled receptor 137
HCRTR2 hypocretin (orexin) receptor 2
HIST1H1D histone cluster 1, H1d
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXA11 homeobox A11
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
IBSP integrin-binding sialoprotein
IFNA8 interferon, alpha 8
ING2 inhibitor of growth family, member 2
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNK10 potassium channel, two pore domain subfamily K, member 10
KLK3 kallikrein-related peptidase 3
KXD1 KxDL motif containing 1
LAMB4 laminin, beta 4
LMF1 lipase maturation factor 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
ONECUT2 one cut homeobox 2
PDCD6 programmed cell death 6
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLA2G16 phospholipase A2, group XVI
PLCH1 phospholipase C, eta 1
PLXNC1 plexin C1
POU4F1 POU class 4 homeobox 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PTCRA pre T-cell antigen receptor alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11B RAB11B, member RAS oncogene family
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBPMS RNA binding protein with multiple splicing
RGS11 regulator of G-protein signaling 11
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS11 ribosomal protein S11
SCARA3 scavenger receptor class A, member 3
SDC1 syndecan 1
SFRP4 secreted frizzled-related protein 4
SH2D3A SH2 domain containing 3A
SIX2 SIX homeobox 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SOGA1 suppressor of glucose, autophagy associated 1
SPRR2B small proline-rich protein 2B
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYT1 synaptotagmin I
TBC1D22B TBC1 domain family, member 22B
TEX13A testis expressed 13A
TEX40 testis expressed 40
TFDP3 transcription factor Dp family, member 3
TFR2 transferrin receptor 2
THY1 Thy-1 cell surface antigen
TP73-AS1 TP73 antisense RNA 1
TTC12 tetratricopeptide repeat domain 12
VEGFC vascular endothelial growth factor C
ZBTB1 zinc finger and BTB domain containing 1
ZNF235 zinc finger protein 235
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADGRA3 adhesion G protein-coupled receptor A3
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARID5A AT rich interactive domain 5A (MRF1-like)
ASB7 ankyrin repeat and SOCS box containing 7
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD2B ATPase family, AAA domain containing 2B
C12ORF4 chromosome 12 open reading frame 4
C17ORF80 chromosome 17 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
CBR4 carbonyl reductase 4
CBX7 chromobox homolog 7
CCDC106 coiled-coil domain containing 106
CCDC57 coiled-coil domain containing 57
CCRL2 chemokine (C-C motif) receptor-like 2
CD9 CD9 molecule
CDA cytidine deaminase
CHIC2 cysteine-rich hydrophobic domain 2
CLCN5 chloride channel, voltage-sensitive 5
CLDND1 claudin domain containing 1
CLGN calmegin
CRIP1 cysteine-rich protein 1 (intestinal)
CSNK1G3 casein kinase 1, gamma 3
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DENND5B DENN/MADD domain containing 5B
DHRS11 dehydrogenase/reductase (SDR family) member 11
EGR3 early growth response 3
FADD Fas (TNFRSF6)-associated via death domain
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXD1 forkhead box D1
FOXK2 forkhead box K2
GBP2 guanylate binding protein 2, interferon-inducible
GPRC5C G protein-coupled receptor, class C, group 5, member C
GTPBP2 GTP binding protein 2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMGB3P1 high mobility group box 3 pseudogene 1
HSPA4L heat shock 70kDa protein 4-like
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
IL2RG interleukin 2 receptor, gamma
ITGA10 integrin, alpha 10
ITGB7 integrin, beta 7
KIAA0319L KIAA0319-like
KIAA0556 KIAA0556
KIAA1024 KIAA1024
KIAA1107 KIAA1107
KIF20A kinesin family member 20A
KLHL26 kelch-like family member 26
KLK5 kallikrein-related peptidase 5
KPNA4 karyopherin alpha 4 (importin alpha 3)
LIN7A lin-7 homolog A (C. elegans)
LINC00597 long intergenic non-protein coding RNA 597
LOC202181 SUMO-interacting motifs containing 1 pseudogene
METTL16 methyltransferase like 16
MOCS3 molybdenum cofactor synthesis 3
NFE2L3 nuclear factor, erythroid 2-like 3
NHEJ1 nonhomologous end-joining factor 1
NT5DC3 5'-nucleotidase domain containing 3
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PHACTR4 phosphatase and actin regulator 4
PODXL2 podocalyxin-like 2
PORCN porcupine homolog (Drosophila)
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRR7 proline rich 7 (synaptic)
PRSS53 protease, serine, 53
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF122 ring finger protein 122
RNF139 ring finger protein 139
RNF19B ring finger protein 19B
SERINC5 serine incorporator 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLITRK5 SLIT and NTRK-like family, member 5
SNIP1 Smad nuclear interacting protein 1
SPAG1 sperm associated antigen 1
SPP1 secreted phosphoprotein 1
STX1A syntaxin 1A (brain)
SYCP2 synaptonemal complex protein 2
TESK2 testis-specific kinase 2
TMC5 transmembrane channel-like 5
TMEM230 transmembrane protein 230
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPBG trophoblast glycoprotein
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPS1 trichorhinophalangeal syndrome I
TWSG1 twisted gastrulation BMP signaling modulator 1
UCN urocortin
UNC13B unc-13 homolog B (C. elegans)
UPP1 uridine phosphorylase 1
VASH2 vasohibin 2
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR76 WD repeat domain 76
ZMYM3 zinc finger, MYM-type 3
ZNF276 zinc finger protein 276
ZNF329 zinc finger protein 329
ZNF667 zinc finger protein 667