mevalolactone-3459 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the mevalolactone-3459 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM22 ADAM metallopeptidase domain 22
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ANXA2P3 annexin A2 pseudogene 3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARC activity-regulated cytoskeleton-associated protein
ARL3 ADP-ribosylation factor-like 3
ARTN artemin
BRCA2 breast cancer 2, early onset
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCPG1 cell cycle progression 1
CD1A CD1a molecule
CDC25A cell division cycle 25A
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCN7 chloride channel, voltage-sensitive 7
CNOT8 CCR4-NOT transcription complex, subunit 8
CRIP1 cysteine-rich protein 1 (intestinal)
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTNS cystinosin, lysosomal cystine transporter
CXXC4 CXXC finger protein 4
DCAF15 DDB1 and CUL4 associated factor 15
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DIO2 deiodinase, iodothyronine, type II
DOK4 docking protein 4
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
DUSP2 dual specificity phosphatase 2
EAF2 ELL associated factor 2
EGFR epidermal growth factor receptor
EPOR erythropoietin receptor
FAM46C family with sequence similarity 46, member C
FBXO31 F-box protein 31
FCMR Fc fragment of IgM receptor
FKRP fukutin related protein
FPGS folylpolyglutamate synthase
FUS FUS RNA binding protein
HFE hemochromatosis
HN1L hematological and neurological expressed 1-like
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IGFBP5 insulin-like growth factor binding protein 5
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IQCG IQ motif containing G
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCTD7 potassium channel tetramerization domain containing 7
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL25 kelch-like family member 25
LHX6 LIM homeobox 6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MOCS1 molybdenum cofactor synthesis 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NACA2 nascent polypeptide-associated complex alpha subunit 2
NADK NAD kinase
NCALD neurocalcin delta
NCOA2 nuclear receptor coactivator 2
NDRG2 NDRG family member 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NKX3-2 NK3 homeobox 2
PBX2 pre-B-cell leukemia homeobox 2
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB11B RAB11B, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RASAL2 RAS protein activator like 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RERE arginine-glutamic acid dipeptide (RE) repeats
RNMT RNA (guanine-7-) methyltransferase
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS3A ribosomal protein S3A
RUNX1 runt-related transcription factor 1
SCAF4 SR-related CTD-associated factor 4
SCAPER S-phase cyclin A-associated protein in the ER
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SPTBN1 spectrin, beta, non-erythrocytic 1
STOML1 stomatin (EPB72)-like 1
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAZ tafazzin
TBX19 T-box 19
TGFB2 transforming growth factor, beta 2
TLK1 tousled-like kinase 1
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPMT thiopurine S-methyltransferase
TRAF2 TNF receptor-associated factor 2
TUBA3D tubulin, alpha 3d
USB1 U6 snRNA biogenesis 1
ZBTB1 zinc finger and BTB domain containing 1
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC14 zinc finger, DHHC-type containing 14
ZHX3 zinc fingers and homeoboxes 3
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF428 zinc finger protein 428

decreased expression

Symbol Name
ANXA1 annexin A1
ARHGAP11A Rho GTPase activating protein 11A
ARRB1 arrestin, beta 1
ASAP1-IT1 ASAP1 intronic transcript 1
ATAD3A ATPase family, AAA domain containing 3A
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHD1 bromo adjacent homology domain containing 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL9 B-cell CLL/lymphoma 9
BCORL1 BCL6 corepressor-like 1
BGLAP bone gamma-carboxyglutamate (gla) protein
C2ORF54 chromosome 2 open reading frame 54
C4ORF29 chromosome 4 open reading frame 29
CCDC121 coiled-coil domain containing 121
CCNO cyclin O
CDK20 cyclin-dependent kinase 20
CLSPN claspin
CNGB3 cyclic nucleotide gated channel beta 3
CST6 cystatin E/M
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPPK1 epiplakin 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM188A family with sequence similarity 188, member A
FMOD fibromodulin
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HLA-J major histocompatibility complex, class I, J (pseudogene)
IDI2-AS1 IDI2 antisense RNA 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IREB2 iron-responsive element binding protein 2
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD4 jumonji domain containing 4
KCNK12 potassium channel, two pore domain subfamily K, member 12
KDM5C lysine (K)-specific demethylase 5C
KIAA0355 KIAA0355
KIF13B kinesin family member 13B
LMCD1 LIM and cysteine-rich domains 1
LPAR4 lysophosphatidic acid receptor 4
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBTD1 mbt domain containing 1
MED18 mediator complex subunit 18
MFSD11 major facilitator superfamily domain containing 11
MTCP1 mature T-cell proliferation 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NDE1 nudE neurodevelopment protein 1
NEK11 NIMA-related kinase 11
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PCF11 PCF11 cleavage and polyadenylation factor subunit
PLA2G3 phospholipase A2, group III
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRPH peripherin
RASAL1 RAS protein activator like 1 (GAP1 like)
RECQL4 RecQ protein-like 4
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPGR retinitis pigmentosa GTPase regulator
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIRT6 sirtuin 6
SLMO1 slowmo homolog 1 (Drosophila)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SRD5A3 steroid 5 alpha-reductase 3
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SYCP2 synaptonemal complex protein 2
TAGLN transgelin
TESC tescalcin
TGIF1 TGFB-induced factor homeobox 1
TIPRL TOR signaling pathway regulator
TMPRSS3 transmembrane protease, serine 3
TNS2 tensin 2
TOM1 target of myb1 (chicken)
TRAIP TRAF interacting protein
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TSPYL2 TSPY-like 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBXN6 UBX domain protein 6
VASH2 vasohibin 2
WDR19 WD repeat domain 19
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZC3H3 zinc finger CCCH-type containing 3
ZNF365 zinc finger protein 365
ZNF611 zinc finger protein 611
ZNF721 zinc finger protein 721