mica Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description MHC class I polypeptide-related sequence A|This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 100507436)
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Genes

28 genes co-occuring with the biological term mica in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ASIC1 acid sensing (proton gated) ion channel 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
DEPDC5 DEP domain containing 5
DICER1 dicer 1, ribonuclease type III
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HSF1 heat shock transcription factor 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFNA1 interferon, alpha 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
MEFV Mediterranean fever
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
PDIA6 protein disulfide isomerase family A, member 6
RAET1G retinoic acid early transcript 1G
SP1 Sp1 transcription factor
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TLR4 toll-like receptor 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
ULBP1 UL16 binding protein 1
ULBP2 UL16 binding protein 2
ULBP3 UL16 binding protein 3