microspike Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A dynamic, actin-rich projection extending from the surface of a migrating animal cell. (Gene Ontology, GO_0044393)
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Genes

93 proteins co-occuring with the microspike cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
FSCN1 fascin actin-bundling protein 1 1.49606
CDC42 cell division cycle 42 1.4069
FSCN3 fascin actin-bundling protein 3, testicular 1.13983
FSCN2 fascin actin-bundling protein 2, retinal 1.12143
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 1.04984
WASF2 WAS protein family, member 2 0.912977
THBS1 thrombospondin 1 0.854339
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.785986
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.784156
FN1 fibronectin 1 0.783698
WASF3 WAS protein family, member 3 0.771363
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.750904
PLEK pleckstrin 0.750904
FGD3 FYVE, RhoGEF and PH domain containing 3 0.746381
FGD4 FYVE, RhoGEF and PH domain containing 4 0.739163
MCF2 MCF.2 cell line derived transforming sequence 0.734217
LGALS8 lectin, galactoside-binding, soluble, 8 0.724812
PLS1 plastin 1 0.705714
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 0.702185
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.6638
EVL Enah/Vasp-like 0.656464
PFN1 profilin 1 0.633305
NGF nerve growth factor (beta polypeptide) 0.590553
EZR ezrin 0.577164
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 0.554732
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.548122
VCL vinculin 0.546885
DBN1 drebrin 1 0.541529
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.533719
WAS Wiskott-Aldrich syndrome 0.531668
TRIP10 thyroid hormone receptor interactor 10 0.531668
PALM paralemmin 0.509604
VASP vasodilator-stimulated phosphoprotein 0.485289
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.481661
MSN moesin 0.477233
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 0.475223
ICOSLG inducible T-cell co-stimulator ligand 0.470406
PFN4 profilin family, member 4 0.454019
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.453223
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.452825
PKN1 protein kinase N1 0.452029
CHN1 chimerin 1 0.450836
ITGB5 integrin, beta 5 0.448848
PFN2 profilin 2 0.439333
RAB5C RAB5C, member RAS oncogene family 0.438937
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.429072
FGD1 FYVE, RhoGEF and PH domain containing 1 0.428284
VAV1 vav 1 guanine nucleotide exchange factor 0.417294
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.416511
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.408309
GRB2 growth factor receptor-bound protein 2 0.395873
TIAM1 T-cell lymphoma invasion and metastasis 1 0.388909
PXN paxillin 0.356324
DNM2 dynamin 2 0.355183
CSPG4 chondroitin sulfate proteoglycan 4 0.346829
SHD Src homology 2 domain containing transforming protein D 0.344935
MTSS1 metastasis suppressor 1 0.343799
TPM1 tropomyosin 1 (alpha) 0.343421
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.341151
TEK TEK tyrosine kinase, endothelial 0.318579
IQGAP1 IQ motif containing GTPase activating protein 1 0.312597
NBPF1 neuroblastoma breakpoint family, member 1 0.306632
VAV3 vav 3 guanine nucleotide exchange factor 0.304771
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.302912
PLS3 plastin 3 0.293267
SEBOX SEBOX homeobox 0.276304
RDX radixin 0.271533
SDC3 syndecan 3 0.270068
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.264946
LIM2 lens intrinsic membrane protein 2, 19kDa 0.264215
RAP1GAP RAP1 GTPase activating protein 0.252202
LIF leukemia inhibitory factor 0.24894
THBS4 thrombospondin 4 0.246769
RASD1 RAS, dexamethasone-induced 1 0.244962
EPB41 erythrocyte membrane protein band 4.1 0.233459
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.232386
FRS2 fibroblast growth factor receptor substrate 2 0.230958
APOLD1 apolipoprotein L domain containing 1 0.230958
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.223143
MARCKS myristoylated alanine-rich protein kinase C substrate 0.219265
VAV2 vav 2 guanine nucleotide exchange factor 0.197662
SDC2 syndecan 2 0.192746
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.183328
MYO1B myosin IB 0.18093
CCL19 chemokine (C-C motif) ligand 19 0.179459
GAP43 growth associated protein 43 0.176305
WASL Wiskott-Aldrich syndrome-like 0.175745
IGF1R insulin-like growth factor 1 receptor 0.173273
MYO10 myosin X 0.169859
BAIAP2 BAI1-associated protein 2 0.16935
PDC phosducin 0.166405
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.161275
AKAP1 A kinase (PRKA) anchor protein 1 0.161275