midodrine-1403 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the midodrine-1403 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACPP acid phosphatase, prostate
AHI1 Abelson helper integration site 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARHGAP32 Rho GTPase activating protein 32
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
C11ORF71 chromosome 11 open reading frame 71
C4ORF29 chromosome 4 open reading frame 29
CADM3 cell adhesion molecule 3
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLIC4 chloride intracellular channel 4
CLIP1 CAP-GLY domain containing linker protein 1
CNOT3 CCR4-NOT transcription complex, subunit 3
CPNE3 copine III
DOC2B double C2-like domains, beta
E2F4 E2F transcription factor 4, p107/p130-binding
ENG endoglin
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FAM134B family with sequence similarity 134, member B
FAM86B1 family with sequence similarity 86, member B1
FEM1B fem-1 homolog b (C. elegans)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GIMAP5 GTPase, IMAP family member 5
GLI3 GLI family zinc finger 3
GPRC5D G protein-coupled receptor, class C, group 5, member D
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSK3A glycogen synthase kinase 3 alpha
HFE hemochromatosis
HNF1B HNF1 homeobox B
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTT huntingtin
IRF2 interferon regulatory factor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LAD1 ladinin 1
LARP4 La ribonucleoprotein domain family, member 4
LBP lipopolysaccharide binding protein
MAGT1 magnesium transporter 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MBTD1 mbt domain containing 1
MED13L mediator complex subunit 13-like
MFN1 mitofusin 1
MKRN3 makorin ring finger protein 3
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MSH3 mutS homolog 3
MXRA8 matrix-remodelling associated 8
NCR2 natural cytotoxicity triggering receptor 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NMB neuromedin B
NPY neuropeptide Y
NUCB1 nucleobindin 1
OMG oligodendrocyte myelin glycoprotein
PADI2 peptidyl arginine deiminase, type II
PCDH17 protocadherin 17
PDCD1 programmed cell death 1
PGC progastricsin (pepsinogen C)
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PKNOX2 PBX/knotted 1 homeobox 2
PLCD1 phospholipase C, delta 1
PLD2 phospholipase D2
POM121L2 POM121 transmembrane nucleoporin-like 2
PRB1 proline-rich protein BstNI subfamily 1
PRDM11 PR domain containing 11
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RABL3 RAB, member of RAS oncogene family-like 3
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
SDC2 syndecan 2
SERBP1 SERPINE1 mRNA binding protein 1
SMG5 SMG5 nonsense mediated mRNA decay factor
SPHK1 sphingosine kinase 1
SRCAP Snf2-related CREBBP activator protein
SSH3 slingshot protein phosphatase 3
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STK19 serine/threonine kinase 19
SUGP1 SURP and G patch domain containing 1
T T, brachyury homolog (mouse)
TCAF1 TRPM8 channel-associated factor 1
TCL1A T-cell leukemia/lymphoma 1A
TPM3 tropomyosin 3
TRAF3IP3 TRAF3 interacting protein 3
TTLL4 tubulin tyrosine ligase-like family member 4
TUBA4B tubulin, alpha 4b
UGDH UDP-glucose 6-dehydrogenase
USF2 upstream transcription factor 2, c-fos interacting
USP2 ubiquitin specific peptidase 2
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
WNT16 wingless-type MMTV integration site family, member 16
WTAP Wilms tumor 1 associated protein
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF778 zinc finger protein 778
ZNF783 zinc finger family member 783
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ADORA3 adenosine A3 receptor
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA2P2 annexin A2 pseudogene 2
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BANP BTG3 associated nuclear protein
BATF3 basic leucine zipper transcription factor, ATF-like 3
BLVRB biliverdin reductase B
C1QTNF1 C1q and tumor necrosis factor related protein 1
CASZ1 castor zinc finger 1
CCDC130 coiled-coil domain containing 130
CCNL2 cyclin L2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEND1 cell cycle exit and neuronal differentiation 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN11 claudin 11
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CRYBB2P1 crystallin, beta B2 pseudogene 1
DBF4 DBF4 zinc finger
DDHD2 DDHD domain containing 2
DEXI Dexi homolog (mouse)
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNM1 dynamin 1
DPF2 D4, zinc and double PHD fingers family 2
EMC9 ER membrane protein complex subunit 9
ERCC8 excision repair cross-complementation group 8
FMO4 flavin containing monooxygenase 4
FZD2 frizzled class receptor 2
GEMIN6 gem (nuclear organelle) associated protein 6
GMEB1 glucocorticoid modulatory element binding protein 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GRM6 glutamate receptor, metabotropic 6
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IER3IP1 immediate early response 3 interacting protein 1
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IRF7 interferon regulatory factor 7
ISCU iron-sulfur cluster assembly enzyme
KCTD13 potassium channel tetramerization domain containing 13
KIFC1 kinesin family member C1
KIZ kizuna centrosomal protein
KLHL21 kelch-like family member 21
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LCMT1 leucine carboxyl methyltransferase 1
LENEP lens epithelial protein
LMAN2L lectin, mannose-binding 2-like
LRP3 low density lipoprotein receptor-related protein 3
MAPK12 mitogen-activated protein kinase 12
MED9 mediator complex subunit 9
MEN1 multiple endocrine neoplasia I
METRN meteorin, glial cell differentiation regulator
MFF mitochondrial fission factor
MFSD11 major facilitator superfamily domain containing 11
NAP1L4 nucleosome assembly protein 1-like 4
NCAPH non-SMC condensin I complex, subunit H
NHEJ1 nonhomologous end-joining factor 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OSBPL11 oxysterol binding protein-like 11
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNOC prepronociceptin
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
RABEPK Rab9 effector protein with kelch motifs
RBM41 RNA binding motif protein 41
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RORC RAR-related orphan receptor C
RPL13P5 ribosomal protein L13 pseudogene 5
RPS10P5 ribosomal protein S10 pseudogene 5
SETMAR SET domain and mariner transposase fusion gene
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOD3 superoxide dismutase 3, extracellular
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
STIL SCL/TAL1 interrupting locus
STXBP1 syntaxin binding protein 1
TCTN2 tectonic family member 2
TEX40 testis expressed 40
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TOR4A torsin family 4, member A
TRIM22 tripartite motif containing 22
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TST thiosulfate sulfurtransferase (rhodanese)
TTC23 tetratricopeptide repeat domain 23
USP32 ubiquitin specific peptidase 32
WWC2 WW and C2 domain containing 2
ZBTB48 zinc finger and BTB domain containing 48
ZNF14 zinc finger protein 14
ZNF180 zinc finger protein 180
ZNF250 zinc finger protein 250
ZNF35 zinc finger protein 35
ZSCAN26 zinc finger and SCAN domain containing 26