midodrine-2250 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the midodrine-2250 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AHNAK AHNAK nucleoprotein
AIRE autoimmune regulator
ARC activity-regulated cytoskeleton-associated protein
ATG10 autophagy related 10
BLNK B-cell linker
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C1ORF21 chromosome 1 open reading frame 21
C1QB complement component 1, q subcomponent, B chain
C8ORF44 chromosome 8 open reading frame 44
CABIN1 calcineurin binding protein 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CARD9 caspase recruitment domain family, member 9
CCNK cyclin K
CD6 CD6 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
COMT catechol-O-methyltransferase
CPQ carboxypeptidase Q
DCAF4 DDB1 and CUL4 associated factor 4
DLC1 DLC1 Rho GTPase activating protein
DTNA dystrobrevin, alpha
DUSP6 dual specificity phosphatase 6
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERO1LB ERO1-like beta (S. cerevisiae)
EVA1B eva-1 homolog B (C. elegans)
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FH fumarate hydratase
FHL1 four and a half LIM domains 1
FRMD4A FERM domain containing 4A
FXYD5 FXYD domain containing ion transport regulator 5
GFAP glial fibrillary acidic protein
GJD2 gap junction protein, delta 2, 36kDa
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GRM7 glutamate receptor, metabotropic 7
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HFE hemochromatosis
HIST1H4E histone cluster 1, H4e
HOXD1 homeobox D1
ITGA8 integrin, alpha 8
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA0125 KIAA0125
KIF25 kinesin family member 25
LAMC2 laminin, gamma 2
LGALS4 lectin, galactoside-binding, soluble, 4
LIMS2 LIM and senescent cell antigen-like domains 2
MAP4 microtubule-associated protein 4
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MINK1 misshapen-like kinase 1
MKL1 megakaryoblastic leukemia (translocation) 1
MLXIP MLX interacting protein
MMP25 matrix metallopeptidase 25
MOBP myelin-associated oligodendrocyte basic protein
MTCP1 mature T-cell proliferation 1
NEK1 NIMA-related kinase 1
NF2 neurofibromin 2 (merlin)
NUP188 nucleoporin 188kDa
OAZ3 ornithine decarboxylase antizyme 3
OCLM oculomedin
ONECUT2 one cut homeobox 2
PARD6B par-6 family cell polarity regulator beta
PCDH9 protocadherin 9
PDCD2 programmed cell death 2
PHF1 PHD finger protein 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKNOX2 PBX/knotted 1 homeobox 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNB3 plexin B3
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PRM1 protamine 1
PRX periaxin
PXN paxillin
RAP1GAP RAP1 GTPase activating protein
RASAL2 RAS protein activator like 2
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RND1 Rho family GTPase 1
RORC RAR-related orphan receptor C
RUNX1 runt-related transcription factor 1
SEC24A SEC24 family member A
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP4 secreted frizzled-related protein 4
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOR4A torsin family 4, member A
TP63 tumor protein p63
TPSG1 tryptase gamma 1
TRIM29 tripartite motif containing 29
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
VPS13B vacuolar protein sorting 13 homolog B (yeast)
ZFHX2 zinc finger homeobox 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZMAT4 zinc finger, matrin-type 4
ZNF235 zinc finger protein 235
ZNF480 zinc finger protein 480

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
AHNAK2 AHNAK nucleoprotein 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMPD1 adenosine monophosphate deaminase 1
ANXA2P3 annexin A2 pseudogene 3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOLD1 apolipoprotein L domain containing 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCAS1 breast carcinoma amplified sequence 1
BCL9 B-cell CLL/lymphoma 9
C1ORF54 chromosome 1 open reading frame 54
C22ORF46 chromosome 22 open reading frame 46
C2ORF27A chromosome 2 open reading frame 27A
CBX8 chromobox homolog 8
CCDC134 coiled-coil domain containing 134
CCDC25 coiled-coil domain containing 25
CCNJL cyclin J-like
CD34 CD34 molecule
CD83 CD83 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEL carboxyl ester lipase
CLCN6 chloride channel, voltage-sensitive 6
CLDN1 claudin 1
CLSPN claspin
CPNE7 copine VII
DDIT3 DNA-damage-inducible transcript 3
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGKE diacylglycerol kinase, epsilon 64kDa
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNALI1 dynein, axonemal, light intermediate chain 1
DOK5 docking protein 5
EFNA3 ephrin-A3
FAM155A family with sequence similarity 155, member A
FBXL7 F-box and leucine-rich repeat protein 7
FFAR2 free fatty acid receptor 2
FLCN folliculin
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GATA4 GATA binding protein 4
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GSTA4 glutathione S-transferase alpha 4
HIST1H3B histone cluster 1, H3b
HIST1H3E histone cluster 1, H3e
HIST1H4A histone cluster 1, H4a
HPX hemopexin
IGSF1 immunoglobulin superfamily, member 1
IL12RB1 interleukin 12 receptor, beta 1
KLHL36 kelch-like family member 36
LRP2 low density lipoprotein receptor-related protein 2
MAGOH2P mago-nashi homolog 2, pseudogene
MYOZ1 myozenin 1
NOL12 nucleolar protein 12
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX1 neuronal pentraxin I
NT5E 5'-nucleotidase, ecto (CD73)
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OSGIN1 oxidative stress induced growth inhibitor 1
OVOL1 ovo-like zinc finger 1
PAIP2B poly(A) binding protein interacting protein 2B
PARG poly (ADP-ribose) glycohydrolase
PCDHA6 protocadherin alpha 6
PITX2 paired-like homeodomain 2
PLA2G10 phospholipase A2, group X
PODNL1 podocan-like 1
POM121L2 POM121 transmembrane nucleoporin-like 2
PP14571 uncharacterized LOC100130449
PQLC2 PQ loop repeat containing 2
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3A RAB3A, member RAS oncogene family
RAB40C RAB40C, member RAS oncogene family
RFPL1S RFPL1 antisense RNA 1
RNF2 ring finger protein 2
SCN1B sodium channel, voltage gated, type I beta subunit
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEC14L5 SEC14-like 5 (S. cerevisiae)
SH3BGR SH3 domain binding glutamate-rich protein
SIPA1 signal-induced proliferation-associated 1
SIRT2 sirtuin 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAB2 stabilin 2
STARD3 StAR-related lipid transfer (START) domain containing 3
TCTN1 tectonic family member 1
TET3 tet methylcytosine dioxygenase 3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TSPAN2 tetraspanin 2
TTC30A tetratricopeptide repeat domain 30A
UPK3B uroplakin 3B
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEGFC vascular endothelial growth factor C
WDR33 WD repeat domain 33
WDR76 WD repeat domain 76
WFDC2 WAP four-disulfide core domain 2
XDH xanthine dehydrogenase
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBTB44 zinc finger and BTB domain containing 44
ZIM2 zinc finger, imprinted 2