minocycline-1135 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the minocycline-1135 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
ANKRD12 ankyrin repeat domain 12
AOX1 aldehyde oxidase 1
ATP5SL ATP5S-like
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DIAPH1 diaphanous-related formin 1
DIEXF digestive organ expansion factor homolog (zebrafish)
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DMC1 DNA meiotic recombinase 1
DNAAF2 dynein, axonemal, assembly factor 2
DNMBP dynamin binding protein
EFHD2 EF-hand domain family, member D2
ELF1 E74-like factor 1 (ets domain transcription factor)
ESR1 estrogen receptor 1
ETHE1 ethylmalonic encephalopathy 1
FAM188A family with sequence similarity 188, member A
FIP1L1 factor interacting with PAPOLA and CPSF1
GCFC2 GC-rich sequence DNA-binding factor 2
GLT8D1 glycosyltransferase 8 domain containing 1
H2AFX H2A histone family, member X
HCFC1 host cell factor C1
HIRA histone cell cycle regulator
HIST1H2BI histone cluster 1, H2bi
HS1BP3 HCLS1 binding protein 3
HSPB11 heat shock protein family B (small), member 11
HYAL2 hyaluronoglucosaminidase 2
ICA1 islet cell autoantigen 1, 69kDa
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFT81 intraflagellar transport 81
IKZF5 IKAROS family zinc finger 5 (Pegasus)
ING1 inhibitor of growth family, member 1
INTS1 integrator complex subunit 1
ISG15 ISG15 ubiquitin-like modifier
ITSN1 intersectin 1 (SH3 domain protein)
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KIAA0556 KIAA0556
KIAA0894 KIAA0894 protein
KPNA1 karyopherin alpha 1 (importin alpha 5)
L2HGDH L-2-hydroxyglutarate dehydrogenase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIG1 ligase I, DNA, ATP-dependent
MAPK12 mitogen-activated protein kinase 12
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MECP2 methyl CpG binding protein 2
MECR mitochondrial trans-2-enoyl-CoA reductase
MICALL1 MICAL-like 1
MOB1A MOB kinase activator 1A
MVK mevalonate kinase
MYH10 myosin, heavy chain 10, non-muscle
MYO19 myosin XIX
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NCDN neurochondrin
PARD6B par-6 family cell polarity regulator beta
PASK PAS domain containing serine/threonine kinase
PCBP2 poly(rC) binding protein 2
PCGF3 polycomb group ring finger 3
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PHACTR2 phosphatase and actin regulator 2
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTBP3 polypyrimidine tract binding protein 3
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAD54L RAD54-like (S. cerevisiae)
RANGRF RAN guanine nucleotide release factor
RECQL RecQ helicase-like
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RPL15 ribosomal protein L15
RUFY3 RUN and FYVE domain containing 3
SIK3 SIK family kinase 3
SIKE1 suppressor of IKBKE 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMAD5 SMAD family member 5
SPN sialophorin
SRCAP Snf2-related CREBBP activator protein
SRF serum response factor (c-fos serum response element-binding transcription factor)
SSR1 signal sequence receptor, alpha
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TBC1D4 TBC1 domain family, member 4
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TPD52 tumor protein D52
TRAF5 TNF receptor-associated factor 5
TRIO trio Rho guanine nucleotide exchange factor
TUBGCP3 tubulin, gamma complex associated protein 3
TWF1 twinfilin actin binding protein 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
XPO6 exportin 6
YY1 YY1 transcription factor
ZNF266 zinc finger protein 266
ZNF574 zinc finger protein 574
ZNHIT2 zinc finger, HIT-type containing 2

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ADAM15 ADAM metallopeptidase domain 15
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AKIP1 A kinase (PRKA) interacting protein 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGAP11A Rho GTPase activating protein 11A
ARID4A AT rich interactive domain 4A (RBP1-like)
ARRB2 arrestin, beta 2
ASL argininosuccinate lyase
AZI2 5-azacytidine induced 2
BLMH bleomycin hydrolase
C11ORF68 chromosome 11 open reading frame 68
C11ORF95 chromosome 11 open reading frame 95
C12ORF29 chromosome 12 open reading frame 29
C16ORF59 chromosome 16 open reading frame 59
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CASD1 CAS1 domain containing 1
CDK9 cyclin-dependent kinase 9
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CRYL1 crystallin, lambda 1
CYTH2 cytohesin 2
DBR1 debranching RNA lariats 1
DCAF16 DDB1 and CUL4 associated factor 16
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDB1 damage-specific DNA binding protein 1, 127kDa
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EPPK1 epiplakin 1
FBXO46 F-box protein 46
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GRAMD3 GRAM domain containing 3
GUSBP3 glucuronidase, beta pseudogene 3
HHEX hematopoietically expressed homeobox
HINFP histone H4 transcription factor
HPS5 Hermansky-Pudlak syndrome 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL10RB interleukin 10 receptor, beta
IP6K1 inositol hexakisphosphate kinase 1
JMJD1C jumonji domain containing 1C
KCTD15 potassium channel tetramerization domain containing 15
KIF3A kinesin family member 3A
KRI1 KRI1 homolog (S. cerevisiae)
LAMA5 laminin, alpha 5
LAS1L LAS1-like (S. cerevisiae)
LRRC16A leucine rich repeat containing 16A
LRRC42 leucine rich repeat containing 42
MAGEF1 melanoma antigen family F1
MAPK3 mitogen-activated protein kinase 3
MNS1 meiosis-specific nuclear structural 1
NARFL nuclear prelamin A recognition factor-like
NHEJ1 nonhomologous end-joining factor 1
NXN nucleoredoxin
ORC1 origin recognition complex, subunit 1
OXR1 oxidation resistance 1
PAQR4 progestin and adipoQ receptor family member IV
PEPD peptidase D
PKN1 protein kinase N1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PP14571 uncharacterized LOC100130449
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR7 proline rich 7 (synaptic)
PTBP2 polypyrimidine tract binding protein 2
PTPN9 protein tyrosine phosphatase, non-receptor type 9
QTRT1 queuine tRNA-ribosyltransferase 1
RAD51AP1 RAD51 associated protein 1
RFX7 regulatory factor X, 7
RNF123 ring finger protein 123
RNF219 ring finger protein 219
RSAD1 radical S-adenosyl methionine domain containing 1
RUFY2 RUN and FYVE domain containing 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SDF2 stromal cell-derived factor 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMA4 glucuronidase, beta pseudogene
SOBP sine oculis binding protein homolog (Drosophila)
SPATA2L spermatogenesis associated 2-like
STEAP3 STEAP family member 3, metalloreductase
STK25 serine/threonine kinase 25
STX17 syntaxin 17
TBCCD1 TBCC domain containing 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THOP1 thimet oligopeptidase 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM208 transmembrane protein 208
TOLLIP toll interacting protein
TPCN1 two pore segment channel 1
TPST2 tyrosylprotein sulfotransferase 2
TRAPPC2 trafficking protein particle complex 2
TSPO translocator protein (18kDa)
TULP4 tubby like protein 4
UNG uracil-DNA glycosylase
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
ZBTB38 zinc finger and BTB domain containing 38
ZNF124 zinc finger protein 124
ZNF212 zinc finger protein 212
ZNF468 zinc finger protein 468
ZNF654 zinc finger protein 654
ZNF85 zinc finger protein 85