minocycline-5496 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the minocycline-5496 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ADAM12 ADAM metallopeptidase domain 12
AKR1C2 aldo-keto reductase family 1, member C2
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANKFY1 ankyrin repeat and FYVE domain containing 1
APC adenomatous polyposis coli
APC2 adenomatosis polyposis coli 2
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
APOL6 apolipoprotein L, 6
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF105 chromosome 14 open reading frame 105
C22ORF46 chromosome 22 open reading frame 46
CAMKMT calmodulin-lysine N-methyltransferase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CC2D1A coiled-coil and C2 domain containing 1A
CCDC82 coiled-coil domain containing 82
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP104 centrosomal protein 104kDa
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
COL5A1 collagen, type V, alpha 1
COL6A1 collagen, type VI, alpha 1
DAGLA diacylglycerol lipase, alpha
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
DVL3 dishevelled segment polarity protein 3
EDRF1 erythroid differentiation regulatory factor 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ELP6 elongator acetyltransferase complex subunit 6
EPHA5 EPH receptor A5
EPOR erythropoietin receptor
ESR1 estrogen receptor 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
GAMT guanidinoacetate N-methyltransferase
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GLIPR1 GLI pathogenesis-related 1
GPR135 G protein-coupled receptor 135
GPR182 G protein-coupled receptor 182
GSTTP1 glutathione S-transferase theta pseudogene 1
HAP1 huntingtin-associated protein 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIST1H4B histone cluster 1, H4b
HIST1H4H histone cluster 1, H4h
ICOSLG inducible T-cell co-stimulator ligand
IGFBP5 insulin-like growth factor binding protein 5
KIAA1045 KIAA1045
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LRP12 low density lipoprotein receptor-related protein 12
LRRC17 leucine rich repeat containing 17
LUZP1 leucine zipper protein 1
LYRM9 LYR motif containing 9
MAGEA6 melanoma antigen family A6
MC3R melanocortin 3 receptor
MED31 mediator complex subunit 31
MYB v-myb avian myeloblastosis viral oncogene homolog
NF2 neurofibromin 2 (merlin)
NOP14-AS1 NOP14 antisense RNA 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5M 5',3'-nucleotidase, mitochondrial
NYNRIN NYN domain and retroviral integrase containing
PCDH1 protocadherin 1
PKP1 plakophilin 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POU5F1B POU class 5 homeobox 1B
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PQBP1 polyglutamine binding protein 1
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTPRO protein tyrosine phosphatase, receptor type, O
RCAN3 RCAN family member 3
RHOT2 ras homolog family member T2
RPGRIP1L RPGRIP1-like
RRBP1 ribosome binding protein 1
S100A1 S100 calcium binding protein A1
S100A8 S100 calcium binding protein A8
SCN10A sodium channel, voltage gated, type X alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIRT5 sirtuin 5
SLMO1 slowmo homolog 1 (Drosophila)
SMG6 SMG6 nonsense mediated mRNA decay factor
STAT5B signal transducer and activator of transcription 5B
STEAP4 STEAP family member 4
STX3 syntaxin 3
SYT5 synaptotagmin V
TECPR2 tectonin beta-propeller repeat containing 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPRSS15 transmembrane protease, serine 15
TRBC1 T cell receptor beta constant 1
TRIM29 tripartite motif containing 29
UBA7 ubiquitin-like modifier activating enzyme 7
UTS2 urotensin 2
VEGFA vascular endothelial growth factor A
VIM vimentin
ZNF536 zinc finger protein 536
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ALPK1 alpha-kinase 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATG7 autophagy related 7
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
C1QTNF3 C1q and tumor necrosis factor related protein 3
CD83 CD83 molecule
CGREF1 cell growth regulator with EF-hand domain 1
CHPF chondroitin polymerizing factor
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CIR1 corepressor interacting with RBPJ, 1
CLDN15 claudin 15
CLK1 CDC-like kinase 1
DCTN4 dynactin 4 (p62)
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DOCK1 dedicator of cytokinesis 1
DSCAM Down syndrome cell adhesion molecule
EAF2 ELL associated factor 2
ELP3 elongator acetyltransferase complex subunit 3
ERI3 ERI1 exoribonuclease family member 3
ERO1L ERO1-like (S. cerevisiae)
ETAA1 Ewing tumor-associated antigen 1
F2R coagulation factor II (thrombin) receptor
F8 coagulation factor VIII, procoagulant component
FAM86C1 family with sequence similarity 86, member C1
FBXO31 F-box protein 31
FGGY FGGY carbohydrate kinase domain containing
FMO4 flavin containing monooxygenase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FURIN furin (paired basic amino acid cleaving enzyme)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GBP2 guanylate binding protein 2, interferon-inducible
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPX2 glutathione peroxidase 2
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2AJ histone cluster 1, H2aj
HOXC10 homeobox C10
IRX4 iroquois homeobox 4
ISG15 ISG15 ubiquitin-like modifier
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA0513 KIAA0513
LZTR1 leucine-zipper-like transcription regulator 1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MECR mitochondrial trans-2-enoyl-CoA reductase
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYBBP1A MYB binding protein (P160) 1a
MYL5 myosin, light chain 5, regulatory
MYLIP myosin regulatory light chain interacting protein
NCAPH non-SMC condensin I complex, subunit H
NECAB3 N-terminal EF-hand calcium binding protein 3
NIPAL2 NIPA-like domain containing 2
PLEKHA6 pleckstrin homology domain containing, family A member 6
PRKX protein kinase, X-linked
PRODH proline dehydrogenase (oxidase) 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTDSS2 phosphatidylserine synthase 2
PTK6 protein tyrosine kinase 6
RAB23 RAB23, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RBM42 RNA binding motif protein 42
RNF31 ring finger protein 31
RUFY2 RUN and FYVE domain containing 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCIN scinderin
SETMAR SET domain and mariner transposase fusion gene
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPIDR scaffolding protein involved in DNA repair
SREK1IP1 SREK1-interacting protein 1
STX1A syntaxin 1A (brain)
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX19 T-box 19
TESC tescalcin
TIGD6 tigger transposable element derived 6
TMEM183A transmembrane protein 183A
TRAIP TRAF interacting protein
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
URGCP upregulator of cell proliferation
USP20 ubiquitin specific peptidase 20
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XYLT2 xylosyltransferase II
ZBED1 zinc finger, BED-type containing 1
ZNF23 zinc finger protein 23
ZNF34 zinc finger protein 34
ZNF639 zinc finger protein 639
ZNF862 zinc finger protein 862
ZSCAN31 zinc finger and SCAN domain containing 31