mir122 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description microRNA 122|microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 406906)
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Genes

51 genes co-occuring with the biological term mir122 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGO2 argonaute RISC catalytic component 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL2L2 BCL2-like 2
CCHCR1 coiled-coil alpha-helical rod protein 1
CCND1 cyclin D1
CCNG1 cyclin G1
CPT1A carnitine palmitoyltransferase 1A (liver)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUX1 cut-like homeobox 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DICER1 dicer 1, ribonuclease type III
EGFR epidermal growth factor receptor
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GRHL1 grainyhead-like 1 (Drosophila)
HMOX1 heme oxygenase 1
IFNA2 interferon, alpha 2
IGF1R insulin-like growth factor 1 receptor
IL1A interleukin 1, alpha
MIR122 microRNA 122
MIR130A microRNA 130a
MIR145 microRNA 145
MIR195 microRNA 195
MIR199A1 microRNA 199a-1
MIR21 microRNA 21
MIR22 microRNA 22
MIR223 microRNA 223
MIR224 microRNA 224
MIR34A microRNA 34a
MIR370 microRNA 370
MIR542 microRNA 542
MVK mevalonate kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG3 NDRG family member 3
NOD2 nucleotide-binding oligomerization domain containing 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAPD4 PAP associated domain containing 4
PEG10 paternally expressed 10
PPARG peroxisome proliferator-activated receptor gamma
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PTTG1IP pituitary tumor-transforming 1 interacting protein
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
TARBP2 TAR (HIV-1) RNA binding protein 2
TNP2 transition protein 2 (during histone to protamine replacement)
TP53 tumor protein p53
TRPV6 transient receptor potential cation channel, subfamily V, member 6
WNT1 wingless-type MMTV integration site family, member 1
XRN1 5'-3' exoribonuclease 1
XRN2 5'-3' exoribonuclease 2