mir17 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description microRNA 17|microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 406952)
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Genes

35 genes co-occuring with the biological term mir17 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAR adenosine deaminase, RNA-specific
AKT1 v-akt murine thymoma viral oncogene homolog 1
CD46 CD46 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CYBB cytochrome b-245, beta polypeptide
E2F1 E2F transcription factor 1
EPAS1 endothelial PAS domain protein 1
ESR2 estrogen receptor 2 (ER beta)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
KAT2A K(lysine) acetyltransferase 2A
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR106A microRNA 106a
MIR106B microRNA 106b
MIR17 microRNA 17
MIR17HG miR-17-92 cluster host gene
MIR192 microRNA 192
MIR20A microRNA 20a
MIR20B microRNA 20b
MIR21 microRNA 21
MIR221 microRNA 221
MIR222 microRNA 222
MIR223 microRNA 223
MIR29C microRNA 29c
MIR432 microRNA 432
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOX4 NADPH oxidase 4
NPAS3 neuronal PAS domain protein 3
PTEN phosphatase and tensin homolog
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RND3 Rho family GTPase 3
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBC1D2 TBC1 domain family, member 2
TCF3 transcription factor 3
TP63 tumor protein p63