mir21 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description microRNA 21|microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 406991)
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Genes

162 genes co-occuring with the biological term mir21 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
APC adenomatous polyposis coli
AR androgen receptor
ASPN asporin
BCL2 B-cell CLL/lymphoma 2
BMP4 bone morphogenetic protein 4
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTG2 BTG family, member 2
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CTH cystathionine gamma-lyase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYLD cylindromatosis (turban tumor syndrome)
DCN decorin
DROSHA drosha, ribonuclease type III
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR2 estrogen receptor 2 (ER beta)
FASLG Fas ligand (TNF superfamily, member 6)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
FOXP3 forkhead box P3
GAS5 growth arrest-specific 5 (non-protein coding)
GDE1 glycerophosphodiester phosphodiesterase 1
GRHL3 grainyhead-like 3 (Drosophila)
HAS2 hyaluronan synthase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HOTAIR HOX transcript antisense RNA
IFNB1 interferon, beta 1, fibroblast
IGFBP3 insulin-like growth factor binding protein 3
IL6 interleukin 6
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK1 interleukin-1 receptor-associated kinase 1
JAG1 jagged 1
JUN jun proto-oncogene
KLK11 kallikrein-related peptidase 11
KLK13 kallikrein-related peptidase 13
KLK3 kallikrein-related peptidase 3
KRIT1 KRIT1, ankyrin repeat containing
LEP leptin
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MIR122 microRNA 122
MIR125A microRNA 125a
MIR126 microRNA 126
MIR141 microRNA 141
MIR143 microRNA 143
MIR145 microRNA 145
MIR146A microRNA 146a
MIR155 microRNA 155
MIR16-1 microRNA 16-1
MIR17 microRNA 17
MIR181A1 microRNA 181a-1
MIR181A2 microRNA 181a-2
MIR181B1 microRNA 181b-1
MIR182 microRNA 182
MIR193A microRNA 193a
MIR196A1 microRNA 196a-1
MIR196A2 microRNA 196a-2
MIR197 microRNA 197
MIR199A1 microRNA 199a-1
MIR199A2 microRNA 199a-2
MIR19A microRNA 19a
MIR200A microRNA 200a
MIR200B microRNA 200b
MIR203A microRNA 203a
MIR205 microRNA 205
MIR206 microRNA 206
MIR21 microRNA 21
MIR210 microRNA 210
MIR214 microRNA 214
MIR217 microRNA 217
MIR221 microRNA 221
MIR222 microRNA 222
MIR223 microRNA 223
MIR27A microRNA 27a
MIR27B microRNA 27b
MIR29A microRNA 29a
MIR30B microRNA 30b
MIR30C1 microRNA 30c-1
MIR30C2 microRNA 30c-2
MIR30D microRNA 30d
MIR31 microRNA 31
MIR328 microRNA 328
MIR342 microRNA 342
MIR34A microRNA 34a
MIR375 microRNA 375
MIR486-1 microRNA 486-1
MIR92A1 microRNA 92a-1
MIRLET7A1 microRNA let-7a-1
MIRLET7G microRNA let-7g
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYD88 myeloid differentiation primary response 88
NANOG Nanog homeobox
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPPA natriuretic peptide A
NUCLEOLIN nucleolin multifunctional protein
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAPD5 PAP associated domain containing 5
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHF8 PHD finger protein 8
PPARA peroxisome proliferator-activated receptor alpha
PRKCE protein kinase C, epsilon
PTEN phosphatase and tensin homolog
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAN RAN, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOB ras homolog family member B
RNH1 ribonuclease/angiogenin inhibitor 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
SMAD7 SMAD family member 7
SOD3 superoxide dismutase 3, extracellular
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SRRT serrate, RNA effector molecule
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THRB thyroid hormone receptor, beta
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR7 toll-like receptor 7
TNF tumor necrosis factor
TP53 tumor protein p53
TP63 tumor protein p63
TPM1 tropomyosin 1 (alpha)
VEGFA vascular endothelial growth factor A
VMP1 vacuole membrane protein 1
WNT1 wingless-type MMTV integration site family, member 1