mir22 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description microRNA 22|microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 407004)
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Genes

32 genes co-occuring with the biological term mir22 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
BSG basigin (Ok blood group)
CD151 CD151 molecule (Raph blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
ERBB3 erb-b2 receptor tyrosine kinase 3
EZR ezrin
HDAC4 histone deacetylase 4
HDAC6 histone deacetylase 6
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
MAX MYC associated factor X
MIR17 microRNA 17
MIR183 microRNA 183
MIR200B microRNA 200b
MIR20A microRNA 20a
MIR22 microRNA 22
MIR24-1 microRNA 24-1
MIR34A microRNA 34a
MIR375 microRNA 375
MIR451A microRNA 451a
MMP2 matrix metallopeptidase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
PTEN phosphatase and tensin homolog
RCOR1 REST corepressor 1
RGS2 regulator of G-protein signaling 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SP1 Sp1 transcription factor
TIAM1 T-cell lymphoma invasion and metastasis 1
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TP53 tumor protein p53
WNT1 wingless-type MMTV integration site family, member 1