mist1_22510200_pancreas_c57bl6_lof_mouse_gpl6246_gds4341 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS4341
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Genes

722 genes differentially expressed following the mist1_22510200_pancreas_c57bl6_lof_mouse_gpl6246_gds4341 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
AASS aminoadipate-semialdehyde synthase 2.18961
EGF epidermal growth factor 2.1548
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.14985
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 2.14985
WDYHV1 WDYHV motif containing 1 2.14985
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.14985
OSBPL2 oxysterol binding protein-like 2 2.14985
GDE1 glycerophosphodiester phosphodiesterase 1 2.14985
ATP13A2 ATPase type 13A2 2.14985
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.14985
CLDN6 claudin 6 2.14985
BHLHA15 basic helix-loop-helix family, member a15 2.14985
ATPIF1 ATPase inhibitory factor 1 2.14985
PADI2 peptidyl arginine deiminase, type II 2.14985
ERGIC2 ERGIC and golgi 2 2.14985
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.14985
COPZ2 coatomer protein complex, subunit zeta 2 2.14985
GJB1 gap junction protein, beta 1, 32kDa 2.14985
MOXD1 monooxygenase, DBH-like 1 2.14985
GC group-specific component (vitamin D binding protein) 2.14985
RANBP3L RAN binding protein 3-like 2.14985
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.12447
CS citrate synthase 2.12447
SEC11C SEC11 homolog C (S. cerevisiae) 2.11569
C18ORF8 chromosome 18 open reading frame 8 2.1102
UBA5 ubiquitin-like modifier activating enzyme 5 2.06717
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.06717
NUDT22 nudix (nucleoside diphosphate linked moiety X)-type motif 22 2.06717
MIR711 microRNA 711 2.06717
CTRC chymotrypsin C (caldecrin) 2.06717
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 2.06717
ILF2 interleukin enhancer binding factor 2 2.06717
SYNE4 spectrin repeat containing, nuclear envelope family member 4 2.05594
CABP2 calcium binding protein 2 2.05254
NOX4 NADPH oxidase 4 2.04528
CCDC68 coiled-coil domain containing 68 2.04528
RAB3D RAB3D, member RAS oncogene family 2.02349
PYCR2 pyrroline-5-carboxylate reductase family, member 2 2.01925
LZTR1 leucine-zipper-like transcription regulator 1 2.00972
ZMYND8 zinc finger, MYND-type containing 8 2.00663
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 1.99084
ETNK1 ethanolamine kinase 1 1.99084
FOXRED2 FAD-dependent oxidoreductase domain containing 2 1.99084
DOCK7 dedicator of cytokinesis 7 1.99084
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 1.99084
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 1.98472
FUOM fucose mutarotase 1.98292
ERP27 endoplasmic reticulum protein 27 1.98292
GLP1R glucagon-like peptide 1 receptor 1.98292
PYCR1 pyrroline-5-carboxylate reductase 1 1.97989
UQCRB ubiquinol-cytochrome c reductase binding protein 1.96168
NUDC nudC nuclear distribution protein 1.94314
FAT3 FAT atypical cadherin 3 1.93628
LIPH lipase, member H 1.93628
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 1.93628
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.93628
HDAC10 histone deacetylase 10 1.91787
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 1.90242
VEGFB vascular endothelial growth factor B 1.90242
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 1.90242
CHP1 calcineurin-like EF-hand protein 1 1.90242
SERF2 small EDRK-rich factor 2 1.84825
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.82854
CLIC6 chloride intracellular channel 6 1.82854
MIB1 mindbomb E3 ubiquitin protein ligase 1 1.81715
HSF2BP heat shock transcription factor 2 binding protein 1.81715
RNU7-1 RNA, U7 small nuclear 1 1.81715
BCKDK branched chain ketoacid dehydrogenase kinase 1.79066
QTRT1 queuine tRNA-ribosyltransferase 1 1.77246
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 1.76867
SUSD2 sushi domain containing 2 1.74687
CLDN9 claudin 9 1.74077
COX6C cytochrome c oxidase subunit VIc 1.73826
UBXN6 UBX domain protein 6 1.71371
TTC7B tetratricopeptide repeat domain 7B 1.67835
GFRA1 GDNF family receptor alpha 1 1.67835
FAM91A1 family with sequence similarity 91, member A1 1.66519
NAT8B N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene) 1.65064
SPDEF SAM pointed domain containing ETS transcription factor 1.63887
PLIN3 perilipin 3 1.61754
TMEM120B transmembrane protein 120B 1.61754
NDRG2 NDRG family member 2 1.60464
RAB26 RAB26, member RAS oncogene family 1.60464
AK3 adenylate kinase 3 1.57352
CELA2A chymotrypsin-like elastase family, member 2A 1.54648
VWA9 von Willebrand factor A domain containing 9 1.54648
ZBTB18 zinc finger and BTB domain containing 18 1.54648
TMEM150A transmembrane protein 150A 1.54648
PI4K2B phosphatidylinositol 4-kinase type 2 beta 1.54648
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 1.54027
GCDH glutaryl-CoA dehydrogenase 1.54027
FRY furry homolog (Drosophila) 1.54027
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 1.54027
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.5238
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 1.51437
FIGN fidgetin 1.50282
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 1.50282
HTRA2 HtrA serine peptidase 2 1.5006
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 1.49819
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 1.49539
RPL7A ribosomal protein L7a 1.47802
PDE8B phosphodiesterase 8B 1.47802
MIA melanoma inhibitory activity 1.47802
NIPAL2 NIPA-like domain containing 2 1.46888
GALK1 galactokinase 1 1.43612
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 1.39392
ELL2 elongation factor, RNA polymerase II, 2 1.39392
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 1.3933
RPL11 ribosomal protein L11 1.3933
PLCD1 phospholipase C, delta 1 1.3933
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 1.3933
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 1.3933
CRYZL1 crystallin, zeta (quinone reductase)-like 1 1.36748
ARFGEF3 ARFGEF family member 3 1.35679
HMGB1 high mobility group box 1 1.35679
KDM1B lysine (K)-specific demethylase 1B 1.35679
RHOQ ras homolog family member Q 1.34163
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.34163
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.34163
LAMA5 laminin, alpha 5 1.33279
NALCN sodium leak channel, non selective 1.32816
ASRGL1 asparaginase like 1 1.32816
COX4I1 cytochrome c oxidase subunit IV isoform 1 1.27911
DIXDC1 DIX domain containing 1 1.25497
IFFO2 intermediate filament family orphan 2 1.25118
R3HCC1 R3H domain and coiled-coil containing 1 1.238
ANXA6 annexin A6 1.22133
CHUK conserved helix-loop-helix ubiquitous kinase 1.19578
ELMOD2 ELMO/CED-12 domain containing 2 1.19578
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 1.18551
PAQR5 progestin and adipoQ receptor family member V 1.17641
CCRL2 chemokine (C-C motif) receptor-like 2 1.1762
NUCB2 nucleobindin 2 1.1762
EPCAM epithelial cell adhesion molecule 1.1762
HYAL3 hyaluronoglucosaminidase 3 1.1762
PPAPDC1B phosphatidic acid phosphatase type 2 domain containing 1B 1.1762
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 1.1762
VSTM4 V-set and transmembrane domain containing 4 1.1762
RAB25 RAB25, member RAS oncogene family 1.17353
PLA2G1B phospholipase A2, group IB (pancreas) 1.17353
GGT1 gamma-glutamyltransferase 1 1.17353
DOCK4 dedicator of cytokinesis 4 1.17353
COG5 component of oligomeric golgi complex 5 1.17353
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 1.17353
PNLIP pancreatic lipase 1.17353
GIF gastric intrinsic factor (vitamin B synthesis) 1.17353
SEP15 15 kDa selenoprotein 1.17353
TRAPPC12 trafficking protein particle complex 12 1.17353
SNHG5 small nucleolar RNA host gene 5 1.17353
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.17353
FOXP2 forkhead box P2 1.1672
TEX30 testis expressed 30 1.1672
GSTM1 glutathione S-transferase mu 1 1.16689
KAT2A K(lysine) acetyltransferase 2A 1.16689
DYNLL2 dynein, light chain, LC8-type 2 1.16689
C1ORF74 chromosome 1 open reading frame 74 1.16689
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 1.16689
ODC1 ornithine decarboxylase 1 1.16689
TLCD1 TLC domain containing 1 1.14332
TMEM50B transmembrane protein 50B 1.14332
GABPA GA binding protein transcription factor, alpha subunit 60kDa 1.14013
JMJD8 jumonji domain containing 8 1.12752
ACSL5 acyl-CoA synthetase long-chain family member 5 1.12345
CYFIP1 cytoplasmic FMR1 interacting protein 1 1.12345
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 1.12345
ITGA1 integrin, alpha 1 1.07936
SLC46A3 solute carrier family 46, member 3 1.07936
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 1.07936
TM4SF4 transmembrane 4 L six family member 4 0.999796
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.988149
YIPF6 Yip1 domain family, member 6 0.982833
PROM2 prominin 2 0.973243
ASB6 ankyrin repeat and SOCS box containing 6 0.973243
SLA2 Src-like-adaptor 2 0.947265
PDLIM1 PDZ and LIM domain 1 0.941095
CNOT10 CCR4-NOT transcription complex, subunit 10 0.939627
TMEM219 transmembrane protein 219 0.912323
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 0.906466
BMP3 bone morphogenetic protein 3 0.894914
UNC5A unc-5 homolog A (C. elegans) 0.894914
SYTL1 synaptotagmin-like 1 0.893842
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.893098
COPE coatomer protein complex, subunit epsilon 0.879823
PEG3 paternally expressed 3 0.879823
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d 0.879823
CABP1 calcium binding protein 1 0.879823
AGTRAP angiotensin II receptor-associated protein 0.853237
TTYH1 tweety family member 1 0.850934
TEAD2 TEA domain family member 2 0.826685
SOD1 superoxide dismutase 1, soluble 0.815027
SH2D7 SH2 domain containing 7 0.813569
TMEM47 transmembrane protein 47 0.787195
UNC79 unc-79 homolog (C. elegans) 0.787195
IVNS1ABP influenza virus NS1A binding protein 0.787195
PIH1D1 PIH1 domain containing 1 0.787195
ABHD17A abhydrolase domain containing 17A 0.787195
TRAM1 translocation associated membrane protein 1 0.769247
RIOK3 RIO kinase 3 0.758634
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 0.754302
LEPROTL1 leptin receptor overlapping transcript-like 1 0.748439
ADCK4 aarF domain containing kinase 4 0.748439
RNH1 ribonuclease/angiogenin inhibitor 1 0.732864
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.732864
MYO1D myosin ID 0.732864
BICD1 bicaudal D homolog 1 (Drosophila) 0.732864
S100A1 S100 calcium binding protein A1 0.732864
METTL21B methyltransferase like 21B 0.732864
DTNA dystrobrevin, alpha 0.732864
C1RL complement component 1, r subcomponent-like 0.729447
TECR trans-2,3-enoyl-CoA reductase 0.716781
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.716531
OXCT1 3-oxoacid CoA transferase 1 0.716531
PPIF peptidylprolyl isomerase F 0.716531
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 0.716531
DENND4A DENN/MADD domain containing 4A 0.713125
ASB8 ankyrin repeat and SOCS box containing 8 0.706581
EXTL1 exostosin-like glycosyltransferase 1 0.687763
CGRRF1 cell growth regulator with ring finger domain 1 0.67762
SMIM14 small integral membrane protein 14 0.665375
DPP7 dipeptidyl-peptidase 7 0.665375
TSPAN13 tetraspanin 13 0.665375
APCS amyloid P component, serum 0.622286
SLC35F5 solute carrier family 35, member F5 0.622286
CAPRIN2 caprin family member 2 0.606172
CCDC141 coiled-coil domain containing 141 0.597245
DYNLL1 dynein, light chain, LC8-type 1 0.597245
TRIP6 thyroid hormone receptor interactor 6 0.59415
OCLN occludin 0.59415
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.59415
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.59415
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.59415
KIAA1614 KIAA1614 0.583072
ISYNA1 inositol-3-phosphate synthase 1 0.583072
FAM171A1 family with sequence similarity 171, member A1 0.573419
DUSP22 dual specificity phosphatase 22 0.573419
VSIG2 V-set and immunoglobulin domain containing 2 0.573419
DOCK1 dedicator of cytokinesis 1 0.573419
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 0.571276
SAR1B secretion associated, Ras related GTPase 1B 0.571276
CLDN10 claudin 10 0.571276
KIF1B kinesin family member 1B 0.571276
MPV17L MPV17 mitochondrial membrane protein-like 0.571276
AFM afamin 0.563147
WARS tryptophanyl-tRNA synthetase 0.563147
CAT catalase 0.563147
EML3 echinoderm microtubule associated protein like 3 0.542759
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.542279
APIP APAF1 interacting protein 0.542279
GSTM2 glutathione S-transferase mu 2 (muscle) 0.539772
KIAA1324 KIAA1324 0.530518
KIF16B kinesin family member 16B 0.5291
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 0.5291
DMXL2 Dmx-like 2 0.5291
NTN1 netrin 1 0.526982
TBCCD1 TBCC domain containing 1 0.521175
BST2 bone marrow stromal cell antigen 2 0.499451
SNAP29 synaptosomal-associated protein, 29kDa 0.499451
PIPOX pipecolic acid oxidase 0.499451
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.495191
SUGP1 SURP and G patch domain containing 1 0.477431
TPK1 thiamin pyrophosphokinase 1 0.429845
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.429845
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 0.422723
CD320 CD320 molecule 0.422723
FAM221A family with sequence similarity 221, member A 0.418729
ZMYM3 zinc finger, MYM-type 3 0.385616
RND2 Rho family GTPase 2 0.385616
ARL2 ADP-ribosylation factor-like 2 0.382406
NES nestin 0.382151
CREB3L2 cAMP responsive element binding protein 3-like 2 0.374267
TMEM86A transmembrane protein 86A 0.36629
ARHGAP44 Rho GTPase activating protein 44 0.351376
NANS N-acetylneuraminic acid synthase 0.351376
LYRM9 LYR motif containing 9 0.350496
ABHD13 abhydrolase domain containing 13 0.350496
ASL argininosuccinate lyase 0.34928
GCK glucokinase (hexokinase 4) 0.348849
AP4B1 adaptor-related protein complex 4, beta 1 subunit 0.347265
IFT20 intraflagellar transport 20 0.340849
JMJD6 jumonji domain containing 6 0.336265
ARSG arylsulfatase G 0.329973
POC1B POC1 centriolar protein B 0.329973
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.321835
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 0.321566
UBE2I ubiquitin-conjugating enzyme E2I 0.318451
AFF1 AF4/FMR2 family, member 1 0.313931
FXYD6 FXYD domain containing ion transport regulator 6 0.308955
TES testin LIM domain protein 0.307841
PARP11 poly (ADP-ribose) polymerase family, member 11 0.306076
ITFG3 integrin alpha FG-GAP repeat containing 3 0.304915
WDR59 WD repeat domain 59 0.304915
OLA1 Obg-like ATPase 1 0.300864
GLO1 glyoxalase I 0.300864
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.300864
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.300864
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.300864
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.287472
TRABD TraB domain containing 0.287472
PPAP2B phosphatidic acid phosphatase type 2B 0.284812
THOP1 thimet oligopeptidase 1 0.284812
ZNF266 zinc finger protein 266 0.284317
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.281951
HADH hydroxyacyl-CoA dehydrogenase 0.279598
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.279598
DLAT dihydrolipoamide S-acetyltransferase 0.279598
COA7 cytochrome c oxidase assembly factor 7 (putative) 0.277008
TNRC6C trinucleotide repeat containing 6C 0.277008
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.272206
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.269992
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.256797
EIF3J eukaryotic translation initiation factor 3, subunit J 0.255847
AEN apoptosis enhancing nuclease 0.254042
OTUD3 OTU deubiquitinase 3 0.210954
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 0.210954
TSC22D1 TSC22 domain family, member 1 0.210954
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.210954
DUSP26 dual specificity phosphatase 26 (putative) 0.210954
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.210954
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 0.210954
GAL galanin/GMAP prepropeptide 0.205017
SCAP SREBF chaperone 0.204471
SERP1 stress-associated endoplasmic reticulum protein 1 0.182547
REST RE1-silencing transcription factor 0.182228
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 0.182228
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.182091
TMEM63B transmembrane protein 63B 0.179138
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.179138
PGA5 pepsinogen 5, group I (pepsinogen A) 0.179138
MINOS1 mitochondrial inner membrane organizing system 1 0.178419
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 0.178419
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 0.178419
RUFY1 RUN and FYVE domain containing 1 0.178419
TMX2 thioredoxin-related transmembrane protein 2 0.162282
PECR peroxisomal trans-2-enoyl-CoA reductase 0.162282
PLS1 plastin 1 0.162282
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.162282
HBS1L HBS1-like translational GTPase 0.162031
TIFA TRAF-interacting protein with forkhead-associated domain 0.156204
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.154557
PM20D1 peptidase M20 domain containing 1 0.154557
AGMO alkylglycerol monooxygenase 0.154557
RPL37 ribosomal protein L37 0.148645
MTA3 metastasis associated 1 family, member 3 0.148645
PAIP2B poly(A) binding protein interacting protein 2B 0.148645
BRCA1 breast cancer 1, early onset 0.148645
ANKMY2 ankyrin repeat and MYND domain containing 2 0.138228
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 0.109234
LMO4 LIM domain only 4 0.097113
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 0.096033
STAG1 stromal antigen 1 0.096033
QSER1 glutamine and serine rich 1 0.08952
GLTP glycolipid transfer protein 0.068866
TMEM214 transmembrane protein 214 0.060478
TPP2 tripeptidyl peptidase II 0.060478
ATG2B autophagy related 2B 0.058478
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.058478
OCRL oculocerebrorenal syndrome of Lowe 0.058478
GAMT guanidinoacetate N-methyltransferase 0.058478
TMEM164 transmembrane protein 164 0.058478
MYO5C myosin VC 0.057288
WWOX WW domain containing oxidoreductase 0.057288
COMMD6 COMM domain containing 6 0.049763
PORCN porcupine homolog (Drosophila) 0.016859
SIDT2 SID1 transmembrane family, member 2 0.016859
OR8J3 olfactory receptor, family 8, subfamily J, member 3 0.016859
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 0.016859
IGBP1 immunoglobulin (CD79A) binding protein 1 0.016859
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.016859
PLXNB2 plexin B2 0.016859
MR1 major histocompatibility complex, class I-related 0.016859
TRAPPC3 trafficking protein particle complex 3 0.016859
DYDC1 DPY30 domain containing 1 0.016859
CA4 carbonic anhydrase IV 0.012266
SPIRE1 spire-type actin nucleation factor 1 0.002129
UFM1 ubiquitin-fold modifier 1 0.002129
SNX6 sorting nexin 6 0.002129

decreased expression

Symbol Name Standardized Value
ALDOA aldolase A, fructose-bisphosphate -0.37137
CDKN2AIPNL CDKN2A interacting protein N-terminal like -0.370461
RPL18 ribosomal protein L18 -0.370461
TMEM242 transmembrane protein 242 -0.370461
PON3 paraoxonase 3 -0.370164
ZNF442 zinc finger protein 442 -0.370039
PDE4DIP phosphodiesterase 4D interacting protein -0.369003
SLC44A3 solute carrier family 44, member 3 -0.365835
TDH L-threonine dehydrogenase (pseudogene) -0.361867
TRRAP transformation/transcription domain-associated protein -0.361501
SURF1 surfeit 1 -0.361501
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -0.354222
CDIP1 cell death-inducing p53 target 1 -0.353571
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.350869
TMC4 transmembrane channel-like 4 -0.350027
ACSF2 acyl-CoA synthetase family member 2 -0.349611
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.349525
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -0.349381
SPRYD7 SPRY domain containing 7 -0.347764
EIF3K eukaryotic translation initiation factor 3, subunit K -0.347764
PROM1 prominin 1 -0.347604
AIG1 androgen-induced 1 -0.346469
CD81 CD81 molecule -0.346104
MTA1 metastasis associated 1 -0.346104
RPL27 ribosomal protein L27 -0.346104
SOAT1 sterol O-acyltransferase 1 -0.346104
WTIP Wilms tumor 1 interacting protein -0.345724
SNX1 sorting nexin 1 -0.343889
JOSD2 Josephin domain containing 2 -0.34166
EIF3M eukaryotic translation initiation factor 3, subunit M -0.340741
PGAP2 post-GPI attachment to proteins 2 -0.340741
TUBA4A tubulin, alpha 4a -0.340015
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 -0.337563
NLE1 notchless homolog 1 (Drosophila) -0.337072
SFXN2 sideroflexin 2 -0.337072
JAK1 Janus kinase 1 -0.336581
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 -0.33615
GJB2 gap junction protein, beta 2, 26kDa -0.332161
TESK1 testis-specific kinase 1 -0.331611
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -0.331358
NFE2L2 nuclear factor, erythroid 2-like 2 -0.331358
WDR13 WD repeat domain 13 -0.331061
ABHD2 abhydrolase domain containing 2 -0.331061
TROVE2 TROVE domain family, member 2 -0.331061
DEK DEK proto-oncogene -0.329218
GTF2I general transcription factor IIi -0.329218
ACOT13 acyl-CoA thioesterase 13 -0.329218
GSTM4 glutathione S-transferase mu 4 -0.328965
AIP aryl hydrocarbon receptor interacting protein -0.322536
INTS4 integrator complex subunit 4 -0.322536
AGTPBP1 ATP/GTP binding protein 1 -0.318747
SFXN1 sideroflexin 1 -0.31857
HID1 HID1 domain containing -0.317114
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -0.315338
FAM81A family with sequence similarity 81, member A -0.314663
CD9 CD9 molecule -0.313359
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.313359
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.313359
RNASE4 ribonuclease, RNase A family, 4 -0.313359
KIAA1467 KIAA1467 -0.313359
PRDM15 PR domain containing 15 -0.313359
BCO2 beta-carotene oxygenase 2 -0.308742
PARM1 prostate androgen-regulated mucin-like protein 1 -0.305553
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) -0.304231
LARS leucyl-tRNA synthetase -0.304231
KIAA1841 KIAA1841 -0.304231
WDR7 WD repeat domain 7 -0.300782
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.299653
CTBP2 C-terminal binding protein 2 -0.299653
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.299653
VAMP8 vesicle-associated membrane protein 8 -0.297401
AS3MT arsenite methyltransferase -0.297257
AP2A1 adaptor-related protein complex 2, alpha 1 subunit -0.297112
WDR41 WD repeat domain 41 -0.297112
LCMT1 leucine carboxyl methyltransferase 1 -0.297112
GPRC5C G protein-coupled receptor, class C, group 5, member C -0.295657
RXRB retinoid X receptor, beta -0.295599
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 -0.295498
STARD7 StAR-related lipid transfer (START) domain containing 7 -0.293183
ZCCHC8 zinc finger, CCHC domain containing 8 -0.293183
BBS7 Bardet-Biedl syndrome 7 -0.292107
MAGED1 melanoma antigen family D1 -0.289684
MKL2 MKL/myocardin-like 2 -0.286668
RPL10A ribosomal protein L10a -0.285684
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -0.285684
SLC31A2 solute carrier family 31 (copper transporter), member 2 -0.285684
ERO1LB ERO1-like beta (S. cerevisiae) -0.285684
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.285684
SEC24A SEC24 family member A -0.285684
ANKRD24 ankyrin repeat domain 24 -0.285228
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.285228
RPS4X ribosomal protein S4, X-linked -0.284615
CCPG1 cell cycle progression 1 -0.281884
INO80D INO80 complex subunit D -0.28072
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.279641
FUS FUS RNA binding protein -0.277177
GALM galactose mutarotase (aldose 1-epimerase) -0.272898
TMEM9 transmembrane protein 9 -0.266358
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -0.260433
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase -0.260433
ATG4C autophagy related 4C, cysteine peptidase -0.259497
MROH1 maestro heat-like repeat family member 1 -0.259497
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -0.259497
CD3E CD3e molecule, epsilon (CD3-TCR complex) -0.259497
ECHDC2 enoyl CoA hydratase domain containing 2 -0.259497
DHRS7 dehydrogenase/reductase (SDR family) member 7 -0.259497
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -0.259497
DAGLA diacylglycerol lipase, alpha -0.259497
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.259497
JTB jumping translocation breakpoint -0.259497
ASUN asunder spermatogenesis regulator -0.258673
FADS3 fatty acid desaturase 3 -0.257989
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -0.257989
VDAC1 voltage-dependent anion channel 1 -0.257989
TMEM116 transmembrane protein 116 -0.257989
EZR ezrin -0.257989
NECAP1 NECAP endocytosis associated 1 -0.257989
RNF26 ring finger protein 26 -0.257333
SLC38A1 solute carrier family 38, member 1 -0.253877
SUCLG1 succinate-CoA ligase, alpha subunit -0.253877
ADAM10 ADAM metallopeptidase domain 10 -0.253877
MCF2L MCF.2 cell line derived transforming sequence-like -0.253877
BAIAP2L1 BAI1-associated protein 2-like 1 -0.253877
VEZF1 vascular endothelial zinc finger 1 -0.253877
LDHB lactate dehydrogenase B -0.253877
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.253793
RNF11 ring finger protein 11 -0.25097
CERS4 ceramide synthase 4 -0.25097
FTH1 ferritin, heavy polypeptide 1 -0.25097
GYLTL1B glycosyltransferase-like 1B -0.25097
CERS2 ceramide synthase 2 -0.25097
SH3D21 SH3 domain containing 21 -0.25097
RAB11FIP4 RAB11 family interacting protein 4 (class II) -0.25097
MRPL43 mitochondrial ribosomal protein L43 -0.25097
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 -0.25097
FGFR1OP2 FGFR1 oncogene partner 2 -0.25097
NIPSNAP3B nipsnap homolog 3B (C. elegans) -0.248861
CETN3 centrin, EF-hand protein, 3 -0.248861
CD164 CD164 molecule, sialomucin -0.248861
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -0.248861
ETF1 eukaryotic translation termination factor 1 -0.248861
PFAS phosphoribosylformylglycinamidine synthase -0.248861
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) -0.24753
ZNF622 zinc finger protein 622 -0.24753
EMP2 epithelial membrane protein 2 -0.24753
NOMO1 NODAL modulator 1 -0.24753
ARL10 ADP-ribosylation factor-like 10 -0.24753
CSNK1D casein kinase 1, delta -0.24753
TMPRSS2 transmembrane protease, serine 2 -0.24753
DTX2 deltex 2, E3 ubiquitin ligase -0.24753
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.244141
AP4M1 adaptor-related protein complex 4, mu 1 subunit -0.244141
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.24301
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) -0.24294
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -0.24221
DHRS11 dehydrogenase/reductase (SDR family) member 11 -0.24221
RAB24 RAB24, member RAS oncogene family -0.241411
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -0.241301
KIAA1429 KIAA1429 -0.241301
USP3 ubiquitin specific peptidase 3 -0.239471
PKP4 plakophilin 4 -0.237768
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -0.237768
CTAGE5 CTAGE family, member 5 -0.237768
PLXNA2 plexin A2 -0.237768
AKT2 v-akt murine thymoma viral oncogene homolog 2 -0.237686
NUP62CL nucleoporin 62kDa C-terminal like -0.237205
PDS5B PDS5 cohesin associated factor B -0.237014
ZP3 zona pellucida glycoprotein 3 (sperm receptor) -0.237014
NONO non-POU domain containing, octamer-binding -0.236191
AMY2A amylase, alpha 2A (pancreatic) -0.235
SIRT4 sirtuin 4 -0.235
PTBP3 polypyrimidine tract binding protein 3 -0.235
TOX4 TOX high mobility group box family member 4 -0.234043
PAWR PRKC, apoptosis, WT1, regulator -0.234043
STAMBPL1 STAM binding protein-like 1 -0.234043
NOTCH1 notch 1 -0.232569
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -0.232569
RAB11B RAB11B, member RAS oncogene family -0.232569
CD59 CD59 molecule, complement regulatory protein -0.231941
FAM187B family with sequence similarity 187, member B -0.227318
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -0.226097
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.226097
C16ORF62 chromosome 16 open reading frame 62 -0.224811
PTMA prothymosin, alpha -0.224811
C1ORF43 chromosome 1 open reading frame 43 -0.224811
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -0.224811
PCCB propionyl CoA carboxylase, beta polypeptide -0.224811
MGME1 mitochondrial genome maintenance exonuclease 1 -0.222919
TMEM19 transmembrane protein 19 -0.221367
C9ORF152 chromosome 9 open reading frame 152 -0.214981
TMEM30B transmembrane protein 30B -0.211007
CSRP1 cysteine and glycine-rich protein 1 -0.21054
LPP LIM domain containing preferred translocation partner in lipoma -0.21054
ISCU iron-sulfur cluster assembly enzyme -0.210446
SAP18 Sin3A-associated protein, 18kDa -0.20762
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 -0.203992
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 -0.203024
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -0.203024
YBX1 Y box binding protein 1 -0.201713
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -0.200998
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.200998
URI1 URI1, prefoldin-like chaperone -0.200998
FAM195B family with sequence similarity 195, member B -0.200998
RNFT1 ring finger protein, transmembrane 1 -0.200998
NENF neudesin neurotrophic factor -0.200826
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.200826
TBC1D23 TBC1 domain family, member 23 -0.200826
TAMM41 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) -0.200826
CXADR coxsackie virus and adenovirus receptor -0.198778
MMP15 matrix metallopeptidase 15 (membrane-inserted) -0.196812
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.196035
TSTD3 thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 -0.19439
EPHA3 EPH receptor A3 -0.19439
CCNJ cyclin J -0.19414
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.193075
COA5 cytochrome c oxidase assembly factor 5 -0.192142
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.190135
MTX1 metaxin 1 -0.18982
TRIP11 thyroid hormone receptor interactor 11 -0.18982
AP3M2 adaptor-related protein complex 3, mu 2 subunit -0.188549
KCMF1 potassium channel modulatory factor 1 -0.188549
NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.188169
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.182466
FAM173A family with sequence similarity 173, member A -0.182191
DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 -0.181943
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.181107
SPHK1 sphingosine kinase 1 -0.181107
TRIT1 tRNA isopentenyltransferase 1 -0.181107
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -0.181107
IFI27L1 interferon, alpha-inducible protein 27-like 1 -0.181107
RNF123 ring finger protein 123 -0.181107
POGLUT1 protein O-glucosyltransferase 1 -0.181107
COL16A1 collagen, type XVI, alpha 1 -0.18108
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.180009
ARF3 ADP-ribosylation factor 3 -0.177423
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -0.176861
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -0.175346
ACACB acetyl-CoA carboxylase beta -0.175346
CA8 carbonic anhydrase VIII -0.175176
CASC4 cancer susceptibility candidate 4 -0.175176
ELMO3 engulfment and cell motility 3 -0.174014
USF1 upstream transcription factor 1 -0.174014
SLC30A7 solute carrier family 30 (zinc transporter), member 7 -0.173374
STXBP2 syntaxin binding protein 2 -0.173374
PM20D2 peptidase M20 domain containing 2 -0.173374
UBL5 ubiquitin-like 5 -0.170957
NADK NAD kinase -0.170957
PTDSS1 phosphatidylserine synthase 1 -0.169912
QSOX2 quiescin Q6 sulfhydryl oxidase 2 -0.168214
LRRC8B leucine rich repeat containing 8 family, member B -0.166241
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 -0.159866
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q -0.158404
FN3K fructosamine 3 kinase -0.158404
QPCTL glutaminyl-peptide cyclotransferase-like -0.153529
NFASC neurofascin -0.150849
CLPTM1L CLPTM1-like -0.149914
ERLIN2 ER lipid raft associated 2 -0.149914
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -0.149914
MITF microphthalmia-associated transcription factor -0.149914
OSTM1 osteopetrosis associated transmembrane protein 1 -0.149421
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -0.148369
KLHL11 kelch-like family member 11 -0.148369
LTN1 listerin E3 ubiquitin protein ligase 1 -0.148369
PLA2G5 phospholipase A2, group V -0.147073
IZUMO1 izumo sperm-egg fusion 1 -0.147073
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -0.147073
WDR72 WD repeat domain 72 -0.147073
CAPNS1 calpain, small subunit 1 -0.146347
BPHL biphenyl hydrolase-like (serine hydrolase) -0.137652
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -0.128663
FLNB filamin B, beta -0.128202
PRDX2 peroxiredoxin 2 -0.128202
RPS11 ribosomal protein S11 -0.128202
KLK3 kallikrein-related peptidase 3 -0.128202
INPPL1 inositol polyphosphate phosphatase-like 1 -0.121591
TRAK2 trafficking protein, kinesin binding 2 -0.121591
TACC2 transforming, acidic coiled-coil containing protein 2 -0.121591
EHF ets homologous factor -0.119024
NUB1 negative regulator of ubiquitin-like proteins 1 -0.119024
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.119024
ARL6 ADP-ribosylation factor-like 6 -0.119024
TLE6 transducin-like enhancer of split 6 -0.11644
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.11191
SUSD1 sushi domain containing 1 -0.110174
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.110174
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.110174
MECOM MDS1 and EVI1 complex locus -0.110174
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.109182
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.101486
FOXO3 forkhead box O3 -0.100322
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.100322
SLC7A4 solute carrier family 7, member 4 -0.100322
RRAGD Ras-related GTP binding D -0.100322
AKIP1 A kinase (PRKA) interacting protein 1 -0.099212
NIT1 nitrilase 1 -0.0958
PHPT1 phosphohistidine phosphatase 1 -0.0958
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -0.0958
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -0.0958
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -0.0958
SMAGP small cell adhesion glycoprotein -0.095111
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -0.095111
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.090471
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.090471
DCTN4 dynactin 4 (p62) -0.090471
RPS26 ribosomal protein S26 -0.086778
NT5C3B 5'-nucleotidase, cytosolic IIIB -0.086778
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -0.086201
GPATCH2L G patch domain containing 2-like -0.080336
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -0.079702
DPPA3 developmental pluripotency associated 3 -0.079702
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial -0.07953
ABHD11 abhydrolase domain containing 11 -0.065684
IFI30 interferon, gamma-inducible protein 30 -0.062343
SNX22 sorting nexin 22 -0.06165
TST thiosulfate sulfurtransferase (rhodanese) -0.06165
HCFC2 host cell factor C2 -0.06165
INTS12 integrator complex subunit 12 -0.060251
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.060251
CLDN8 claudin 8 -0.060251
PANK4 pantothenate kinase 4 -0.057693
NPDC1 neural proliferation, differentiation and control, 1 -0.054824
C2ORF88 chromosome 2 open reading frame 88 -0.054824
ILF3 interleukin enhancer binding factor 3, 90kDa -0.051902
GPC1 glypican 1 -0.051902
SCAPER S-phase cyclin A-associated protein in the ER -0.051902
RPS27L ribosomal protein S27-like -0.051902
SLC37A3 solute carrier family 37, member 3 -0.050512
FBXO8 F-box protein 8 -0.038312
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.032083
H2AFV H2A histone family, member V -0.032083
WBP1 WW domain binding protein 1 -0.021392
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -0.021392
PRSS3 protease, serine, 3 -0.021392
BIN1 bridging integrator 1 -0.01934
LARP4 La ribonucleoprotein domain family, member 4 -0.01934
INTS7 integrator complex subunit 7 -0.01934
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.01934
S100A16 S100 calcium binding protein A16 -0.01934
TRAPPC10 trafficking protein particle complex 10 -0.015775
EPHA7 EPH receptor A7 -0.015775
UBP1 upstream binding protein 1 (LBP-1a) -0.015775
RPS5 ribosomal protein S5 -0.010478
MIR718 microRNA 718 -0.006011
RAB27A RAB27A, member RAS oncogene family -0.006011
TMC7 transmembrane channel-like 7 -0.006011
CCNI cyclin I -0.006011