mitf Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description microphthalmia-associated transcription factor|This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4286)
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Genes

82 genes co-occuring with the biological term mitf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATF2 activating transcription factor 2
AXL AXL receptor tyrosine kinase
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BEST1 bestrophin 1
BIRC7 baculoviral IAP repeat containing 7
BRAF B-Raf proto-oncogene, serine/threonine kinase
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CREB1 cAMP responsive element binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSK cathepsin K
DCT dopachrome tautomerase
DIAPH1 diaphanous-related formin 1
EP300 E1A binding protein p300
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
GJB2 gap junction protein, beta 2, 26kDa
GPNMB glycoprotein (transmembrane) nmb
GSK3B glycogen synthase kinase 3 beta
HDAC7 histone deacetylase 7
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HINT1 histidine triad nucleotide binding protein 1
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IRF4 interferon regulatory factor 4
JUN jun proto-oncogene
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MAPK3 mitogen-activated protein kinase 3
MARK3 MAP/microtubule affinity-regulating kinase 3
MAX MYC associated factor X
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MET MET proto-oncogene, receptor tyrosine kinase
MIR101-1 microRNA 101-1
MIR137 microRNA 137
MIR148A microRNA 148a
MIR182 microRNA 182
MIR204 microRNA 204
MIR211 microRNA 211
MIR330 microRNA 330
MIR340 microRNA 340
MIR675 microRNA 675
MITF microphthalmia-associated transcription factor
MLANA melan-A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
OTX2 orthodenticle homeobox 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX3 paired box 3
PIAS3 protein inhibitor of activated STAT, 3
PMEL premelanosome protein
POU3F2 POU class 3 homeobox 2
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRMT5 protein arginine methyltransferase 5
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB27A RAB27A, member RAS oncogene family
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAI2 snail family zinc finger 2
SOX10 SRY (sex determining region Y)-box 10
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
T T, brachyury homolog (mouse)
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
TFE3 transcription factor binding to IGHM enhancer 3
TGFB1 transforming growth factor, beta 1
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TYR tyrosinase
TYRO3 TYRO3 protein tyrosine kinase
TYRP1 tyrosinase-related protein 1
USF1 upstream transcription factor 1
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VWA5A von Willebrand factor A domain containing 5A