mmp13 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description matrix metallopeptidase 13|Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4322)
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Genes

104 genes co-occuring with the biological term mmp13 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACVRL1 activin A receptor type II-like 1
ADAM28 ADAM metallopeptidase domain 28
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AGTR1 angiotensin II receptor, type 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15 arachidonate 15-lipoxygenase
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
BSG basigin (Ok blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL3A1 collagen, type III, alpha 1
CREB1 cAMP responsive element binding protein 1
CSK c-src tyrosine kinase
CSPG4 chondroitin sulfate proteoglycan 4
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDR2 discoidin domain receptor tyrosine kinase 2
EDN1 endothelin 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELK1 ELK1, member of ETS oncogene family
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ETV4 ets variant 4
F2R coagulation factor II (thrombin) receptor
F2RL3 coagulation factor II (thrombin) receptor-like 3
FGF2 fibroblast growth factor 2 (basic)
FGF23 fibroblast growth factor 23
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
HDAC7 histone deacetylase 7
HMGB1 high mobility group box 1
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IHH indian hedgehog
IL11 interleukin 11
IL1B interleukin 1, beta
IL6 interleukin 6
IL7 interleukin 7
ING2 inhibitor of growth family, member 2
IRAK1 interleukin-1 receptor-associated kinase 1
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
ITGB6 integrin, beta 6
JAK1 Janus kinase 1
JAK3 Janus kinase 3
JUN jun proto-oncogene
LEP leptin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MIR126 microRNA 126
MIR127 microRNA 127
MIR140 microRNA 140
MIR27A microRNA 27a
MIR27B microRNA 27b
MIR488 microRNA 488
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MUC1 mucin 1, cell surface associated
MYD88 myeloid differentiation primary response 88
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME9 NME/NM23 family member 9
NOV nephroblastoma overexpressed
OSM oncostatin M
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAU plasminogen activator, urokinase
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTK2 protein tyrosine kinase 2
ROR2 receptor tyrosine kinase-like orphan receptor 2
RUNX2 runt-related transcription factor 2
S100A12 S100 calcium binding protein A12
S100A4 S100 calcium binding protein A4
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SP7 Sp7 transcription factor
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
YBX1 Y box binding protein 1