mmp2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description matrix metallopeptidase 2|This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] (NCBI Entrez Gene Database, 4313)
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Genes

302 genes co-occuring with the biological term mmp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADAM17 ADAM metallopeptidase domain 17
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIPOQ adiponectin, C1Q and collagen domain containing
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPT2 angiopoietin 2
ANPEP alanyl (membrane) aminopeptidase
ANTXR2 anthrax toxin receptor 2
ANXA5 annexin A5
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
AURKA aurora kinase A
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
BAG1 BCL2-associated athanogene
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
BCL2L2 BCL2-like 2
BHLHA15 basic helix-loop-helix family, member a15
BMP2 bone morphogenetic protein 2
BMPR1A bone morphogenetic protein receptor, type IA
BSG basigin (Ok blood group)
CA9 carbonic anhydrase IX
CAPN1 calpain 1, (mu/I) large subunit
CAPN7 calpain 7
CAPNS1 calpain, small subunit 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CCL23 chemokine (C-C motif) ligand 23
CD151 CD151 molecule (Raph blood group)
CD24 CD24 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN2A cyclin-dependent kinase inhibitor 2A
CERS2 ceramide synthase 2
CGA glycoprotein hormones, alpha polypeptide
CGB chorionic gonadotropin, beta polypeptide
CLDN4 claudin 4
CLDN5 claudin 5
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COL4A4 collagen, type IV, alpha 4
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
CSF3 colony stimulating factor 3 (granulocyte)
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CTSL cathepsin L
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DDR1 discoidin domain receptor tyrosine kinase 1
DDR2 discoidin domain receptor tyrosine kinase 2
DERL1 derlin 1
DLL4 delta-like 4 (Drosophila)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSPP dentin sialophosphoprotein
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ELN elastin
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV4 ets variant 4
ETV5 ets variant 5
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL3 coagulation factor II (thrombin) receptor-like 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLG filaggrin
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FURIN furin (paired basic amino acid cleaving enzyme)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAL galanin/GMAP prepropeptide
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLI1 GLI family zinc finger 1
GNRH2 gonadotropin-releasing hormone 2
HDAC2 histone deacetylase 2
HEPN1 hepatocellular carcinoma, down-regulated 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-G major histocompatibility complex, class I, G
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA2P heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB1 heat shock 27kDa protein 1
ICAM3 intercellular adhesion molecule 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL5 interleukin 5
IL6 interleukin 6
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
ITGB6 integrin, beta 6
JAK2 Janus kinase 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDR kinase insert domain receptor
KISS1 KiSS-1 metastasis-suppressor
KRT19 keratin 19, type I
L1CAM L1 cell adhesion molecule
LAMA4 laminin, alpha 4
LAMC2 laminin, gamma 2
LEP leptin
LEPQTL1 Leptin, serum levels of
LGALS3 lectin, galactoside-binding, soluble, 3
LOX lysyl oxidase
LPAR5 lysophosphatidic acid receptor 5
LRP1 low density lipoprotein receptor-related protein 1
MAGED1 melanoma antigen family D1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIG7 mig-7
MIR125B1 microRNA 125b-1
MIR146B microRNA 146b
MIR155 microRNA 155
MIR200B microRNA 200b
MIR20A microRNA 20a
MIR29A microRNA 29a
MIR29C microRNA 29c
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MMP25 matrix metallopeptidase 25
MMP28 matrix metallopeptidase 28
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MRC2 mannose receptor, C type 2
MTDH metadherin
MYL1 myosin, light chain 1, alkali; skeletal, fast
MZF1 myeloid zinc finger 1
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOX1 NADPH oxidase 1
NOX4 NADPH oxidase 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR4A1 nuclear receptor subfamily 4, group A, member 1
OCLN occludin
ODC1 ornithine decarboxylase 1
OPTC opticin
OSM oncostatin M
PAEP progestagen-associated endometrial protein
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARP1 poly (ADP-ribose) polymerase 1
PAX6 paired box 6
PCSK6 proprotein convertase subtilisin/kexin type 6
PDPK1 3-phosphoinositide dependent protein kinase 1
PGF placental growth factor
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAU plasminogen activator, urokinase
POU5F1 POU class 5 homeobox 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKD1 protein kinase D1
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRSS8 protease, serine, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTAFR platelet-activating factor receptor
PTEN phosphatase and tensin homolog
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAP1GAP RAP1 GTPase activating protein
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RETN resistin
RHOA ras homolog family member A
RHOC ras homolog family member C
RLN2 relaxin 2
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPSA ribosomal protein SA
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
RYK receptor-like tyrosine kinase
S100A12 S100 calcium binding protein A12
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SDC2 syndecan 2
SHH sonic hedgehog
SIM2 single-minded family bHLH transcription factor 2
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLPI secretory leukocyte peptidase inhibitor
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SNAI1 snail family zinc finger 1
SOCS1 suppressor of cytokine signaling 1
SOD1 superoxide dismutase 1, soluble
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TACR1 tachykinin receptor 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
TJP1 tight junction protein 1
TLN1 talin 1
TLR9 toll-like receptor 9
TNC tenascin C
TNF tumor necrosis factor
TNNI2 troponin I type 2 (skeletal, fast)
TP53 tumor protein p53
TP63 tumor protein p63
TSC2 tuberous sclerosis 2
TTN titin
TWIST1 twist family bHLH transcription factor 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VTN vitronectin
WASF1 WAS protein family, member 1
WISP1 WNT1 inducible signaling pathway protein 1
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36 ZFP36 ring finger protein