modification-dependent protein catabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. (Gene Ontology, GO_0019941)
External Link http://amigo.geneontology.org/amigo/term/GO:0019941
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Genes

209 genes participating in the modification-dependent protein catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANAPC11 anaphase promoting complex subunit 11
ANKIB1 ankyrin repeat and IBR domain containing 1
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARRB1 arrestin, beta 1
ARRDC1 arrestin domain containing 1
ASB2 ankyrin repeat and SOCS box containing 2
ATE1 arginyltransferase 1
ATXN3 ataxin 3
BAG6 BCL2-associated athanogene 6
BFAR bifunctional apoptosis regulator
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C18ORF25 chromosome 18 open reading frame 25
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCAR1 cell division cycle and apoptosis regulator 1
CDC23 cell division cycle 23
CDC34 cell division cycle 34
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CNOT4 CCR4-NOT transcription complex, subunit 4
COPS3 COP9 signalosome subunit 3
CUL3 cullin 3
CUL7 cullin 7
DCST1 DC-STAMP domain containing 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTX3L deltex 3 like, E3 ubiquitin ligase
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ELOC elongin C
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FBXL14 F-box and leucine-rich repeat protein 14
FBXL4 F-box and leucine-rich repeat protein 4
FBXL7 F-box and leucine-rich repeat protein 7
FBXO10 F-box protein 10
FBXO11 F-box protein 11
FBXO21 F-box protein 21
FBXO22 F-box protein 22
FBXO4 F-box protein 4
FBXO45 F-box protein 45
FBXO7 F-box protein 7
FBXO8 F-box protein 8
FBXW4 F-box and WD repeat domain containing 4
FBXW8 F-box and WD repeat domain containing 8
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae)
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ISG15 ISG15 ubiquitin-like modifier
ITCH itchy E3 ubiquitin protein ligase
KCMF1 potassium channel modulatory factor 1
KCTD10 potassium channel tetramerization domain containing 10
KCTD21 potassium channel tetramerization domain containing 21
KCTD6 potassium channel tetramerization domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KLF1 Kruppel-like factor 1 (erythroid)
KLHL15 kelch-like family member 15
KLHL22 kelch-like family member 22
KLHL25 kelch-like family member 25
KLHL3 kelch-like family member 3
KLHL8 kelch-like family member 8
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LONP1 lon peptidase 1, mitochondrial
MAGEF1 melanoma antigen family F1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MKRN2 makorin ring finger protein 2
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MYLIP myosin regulatory light chain interacting protein
NDFIP1 Nedd4 family interacting protein 1
NDFIP2 Nedd4 family interacting protein 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NSFL1C NSFL1 (p97) cofactor (p47)
NTAN1 N-terminal asparagine amidase
NUB1 negative regulator of ubiquitin-like proteins 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PCYOX1 prenylcysteine oxidase 1
PCYOX1L prenylcysteine oxidase 1 like
PINK1 PTEN induced putative kinase 1
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11
PRKN parkin RBR E3 ubiquitin protein ligase
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RBBP6 retinoblastoma binding protein 6
RBX1 ring-box 1, E3 ubiquitin protein ligase
RC3H1 ring finger and CCCH-type domains 1
RC3H2 ring finger and CCCH-type domains 2
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RLIM ring finger protein, LIM domain interacting
RNF11 ring finger protein 11
RNF111 ring finger protein 111
RNF114 ring finger protein 114
RNF123 ring finger protein 123
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126 ring finger protein 126
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF13 ring finger protein 13
RNF130 ring finger protein 130
RNF133 ring finger protein 133
RNF14 ring finger protein 14
RNF144A ring finger protein 144A
RNF144B ring finger protein 144B
RNF146 ring finger protein 146
RNF148 ring finger protein 148
RNF149 ring finger protein 149
RNF150 ring finger protein 150
RNF166 ring finger protein 166
RNF167 ring finger protein 167
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF185 ring finger protein 185
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RNF213 ring finger protein 213
RNF215 ring finger protein 215
RNF217 ring finger protein 217
RNF25 ring finger protein 25
RNF26 ring finger protein 26
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RNF43 ring finger protein 43
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RNF6 ring finger protein (C3H2C3 type) 6
RNF7 ring finger protein 7
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPGR retinitis pigmentosa GTPase regulator
RPS27A ribosomal protein S27a
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4
SQSTM1 sequestosome 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase
TOLLIP toll interacting protein
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRIM25 tripartite motif containing 25
TRIM31 tripartite motif containing 31
TRIM32 tripartite motif containing 32
TRIP12 thyroid hormone receptor interactor 12
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TTC3 tetratricopeptide repeat domain 3
UBA1 ubiquitin-like modifier activating enzyme 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBA6 ubiquitin-like modifier activating enzyme 6
UBB ubiquitin B
UBC ubiquitin C
UBD ubiquitin D
UBE2A ubiquitin-conjugating enzyme E2A
UBE2B ubiquitin-conjugating enzyme E2B
UBE2C ubiquitin-conjugating enzyme E2C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2G1 ubiquitin-conjugating enzyme E2G 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2H ubiquitin-conjugating enzyme E2H
UBE2I ubiquitin-conjugating enzyme E2I
UBE2J2 ubiquitin-conjugating enzyme E2, J2
UBE2K ubiquitin-conjugating enzyme E2K
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE2L5 ubiquitin conjugating enzyme E2 L5
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBE2R2 ubiquitin-conjugating enzyme E2R 2
UBE2S ubiquitin-conjugating enzyme E2S
UBE3A ubiquitin protein ligase E3A
UBE3B ubiquitin protein ligase E3B
UBE3C ubiquitin protein ligase E3C
UBE4B ubiquitination factor E4B
UBL4A ubiquitin-like 4A
UBL7 ubiquitin-like 7
UBQLN1 ubiquilin 1
UBQLN2 ubiquilin 2
UBQLN3 ubiquilin 3
UBQLN4 ubiquilin 4
UBQLNL ubiquilin-like
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UFD1 ubiquitin recognition factor in ER associated degradation 1
UHRF1 ubiquitin-like with PHD and ring finger domains 1
USP33 ubiquitin specific peptidase 33
VCP valosin containing protein
WDR81 WD repeat domain 81
WDR91 WD repeat domain 91
XBP1 X-box binding protein 1
ZNRF3 zinc and ring finger 3
ZNRF4 zinc and ring finger 4