modiolus Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The central pillar or columella of the cochlea. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001693)
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Genes

252 proteins co-occuring with the tissue modiolus in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
NTF3 neurotrophin 3 2.14322
BDNF brain-derived neurotrophic factor 2.05996
GJB2 gap junction protein, beta 2, 26kDa 1.54006
TMPRSS3 transmembrane protease, serine 3 1.50717
GDNF glial cell derived neurotrophic factor 1.37819
ATOH1 atonal homolog 1 (Drosophila) 1.26486
CLRN1 clarin 1 1.25726
TBC1D24 TBC1 domain family, member 24 1.22648
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 1.21713
NOX3 NADPH oxidase 3 1.20111
TMPRSS4 transmembrane protease, serine 4 1.15894
ARTN artemin 1.12925
DFNB59 deafness, autosomal recessive 59 1.11641
LOXHD1 lipoxygenase homology domains 1 1.08413
SOX10 SRY (sex determining region Y)-box 10 1.07176
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.06956
DONSON downstream neighbor of SON 1.04093
EPHB3 EPH receptor B3 1.00719
DNTT DNA nucleotidylexotransferase 0.987597
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 0.964199
NGF nerve growth factor (beta polypeptide) 0.959017
POU4F1 POU class 4 homeobox 1 0.941785
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.940925
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 0.931908
CALB1 calbindin 1, 28kDa 0.921627
CALB2 calbindin 2 0.91052
NEUROG1 neurogenin 1 0.907535
EPHA4 EPH receptor A4 0.905404
SYP synaptophysin 0.885015
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.880358
NGFR nerve growth factor receptor 0.859679
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.859258
TMPRSS5 transmembrane protease, serine 5 0.854629
PVALB parvalbumin 0.850845
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.849585
NRTN neurturin 0.833642
GRXCR1 glutaredoxin, cysteine rich 1 0.832804
MYO7A myosin VIIA 0.822339
CTBP2 C-terminal binding protein 2 0.819412
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.808134
PHEX phosphate regulating endopeptidase homolog, X-linked 0.805213
CDH23 cadherin-related 23 0.795208
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.794375
BSN bassoon presynaptic cytomatrix protein 0.778155
GJB6 gap junction protein, beta 6, 30kDa 0.759086
S100A1 S100 calcium binding protein A1 0.755777
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 0.751231
SKA1 spindle and kinetochore associated complex subunit 1 0.739266
NEFL neurofilament, light polypeptide 0.735971
JUN jun proto-oncogene 0.732677
MPZ myelin protein zero 0.731442
SLITRK6 SLIT and NTRK-like family, member 6 0.725274
NTF4 neurotrophin 4 0.71501
NEUROD1 neuronal differentiation 1 0.708041
TMIE transmembrane inner ear 0.701899
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 0.70108
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.68188
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.671285
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.670064
MSRB3 methionine sulfoxide reductase B3 0.666809
SYNJ2 synaptojanin 2 0.648938
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.646505
PSPN persephin 0.644479
CNTF ciliary neurotrophic factor 0.644479
DNAH8 dynein, axonemal, heavy chain 8 0.640833
PCDH15 protocadherin-related 15 0.638809
SIK3 SIK family kinase 3 0.63638
TFB1M transcription factor B1, mitochondrial 0.635572
HSPA4L heat shock 70kDa protein 4-like 0.62991
EFNB2 ephrin-B2 0.626677
HSPA4 heat shock 70kDa protein 4 0.62385
NGEF neuronal guanine nucleotide exchange factor 0.622639
GATA3 GATA binding protein 3 0.620217
ESPN espin 0.614974
CAPN1 calpain 1, (mu/I) large subunit 0.610138
POU4F3 POU class 4 homeobox 3 0.609332
NTS neurotensin 0.604502
CARD10 caspase recruitment domain family, member 10 0.600479
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.595656
ADGRV1 adhesion G protein-coupled receptor V1 0.588832
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.586427
LMO4 LIM domain only 4 0.58242
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 0.581618
GJB4 gap junction protein, beta 4, 30.3kDa 0.577215
EFS embryonal Fyn-associated substrate 0.56603
PSMC3IP PSMC3 interacting protein 0.560449
AQP2 aquaporin 2 (collecting duct) 0.558457
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.558457
FKBP8 FK506 binding protein 8, 38kDa 0.558059
S100A6 S100 calcium binding protein A6 0.556865
METRN meteorin, glial cell differentiation regulator 0.555671
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.554478
EPHB2 EPH receptor B2 0.55249
TRPM4 transient receptor potential cation channel, subfamily M, member 4 0.550503
S100A5 S100 calcium binding protein A5 0.550106
TUB tubby bipartite transcription factor 0.540188
FGF2 fibroblast growth factor 2 (basic) 0.539
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.523194
TMC1 transmembrane channel-like 1 0.521617
EDNRB endothelin receptor type B 0.516104
PTGFR prostaglandin F receptor (FP) 0.515317
POU4F2 POU class 4 homeobox 2 0.513743
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.511384
DNER delta/notch-like EGF repeat containing 0.511384
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.50942
ISL1 ISL LIM homeobox 1 0.509027
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.508635
GTF2IRD1 GTF2I repeat domain containing 1 0.505102
FBXO2 F-box protein 2 0.504318
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 0.501574
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 0.496092
CNGA4 cyclic nucleotide gated channel alpha 4 0.494136
MAPK8 mitogen-activated protein kinase 8 0.489447
SOD2 superoxide dismutase 2, mitochondrial 0.487496
KIF1BP KIF1 binding protein 0.482817
HPN hepsin 0.482038
ARSA arylsulfatase A 0.481259
FGF1 fibroblast growth factor 1 (acidic) 0.48087
UBE2K ubiquitin-conjugating enzyme E2K 0.479312
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.478145
DFNB31 deafness, autosomal recessive 31 0.476589
NTN1 netrin 1 0.464561
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.459532
SORT1 sortilin 1 0.457987
OPRK1 opioid receptor, kappa 1 0.456828
SOX2 SRY (sex determining region Y)-box 2 0.450657
GJC3 gap junction protein, gamma 3, 30.2kDa 0.449116
AQP3 aquaporin 3 (Gill blood group) 0.438739
GLB1 galactosidase, beta 1 0.437205
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.436438
POLG polymerase (DNA directed), gamma 0.43146
CIDEB cell death-inducing DFFA-like effector b 0.427636
PDLIM1 PDZ and LIM domain 1 0.427254
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.424199
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.417337
CREB1 cAMP responsive element binding protein 1 0.417337
ENO2 enolase 2 (gamma, neuronal) 0.415814
FLT1 fms-related tyrosine kinase 1 0.412011
NOS1 nitric oxide synthase 1 (neuronal) 0.407453
SLC26A5 solute carrier family 26 (anion exchanger), member 5 0.402144
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.393819
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.392309
PAX2 paired box 2 0.389289
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.387781
PANX3 pannexin 3 0.383637
XPC xeroderma pigmentosum, complementation group C 0.382131
EFNB1 ephrin-B1 0.379875
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.375368
SLC25A27 solute carrier family 25, member 27 0.371994
MRAP melanocortin 2 receptor accessory protein 0.371245
TAC1 tachykinin, precursor 1 0.369747
GFAP glial fibrillary acidic protein 0.369373
NPR3 natriuretic peptide receptor 3 0.36825
PKD2L1 polycystic kidney disease 2-like 1 0.367502
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 0.362273
CPLX1 complexin 1 0.361901
NES nestin 0.359664
TSPAN1 tetraspanin 1 0.359292
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.355942
RIPK3 receptor-interacting serine-threonine kinase 3 0.352227
BAX BCL2-associated X protein 0.350372
ADAM23 ADAM metallopeptidase domain 23 0.34371
GJC2 gap junction protein, gamma 2, 47kDa 0.342233
PANX2 pannexin 2 0.33965
UBE2S ubiquitin-conjugating enzyme E2S 0.3356
PRPS1 phosphoribosyl pyrophosphate synthetase 1 0.335233
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.334498
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.329361
XPA xeroderma pigmentosum, complementation group A 0.329361
MBP myelin basic protein 0.328262
TBCE tubulin folding cofactor E 0.326798
FOS FBJ murine osteosarcoma viral oncogene homolog 0.323874
SSTR1 somatostatin receptor 1 0.320956
SDF4 stromal cell derived factor 4 0.31877
RAB3B RAB3B, member RAS oncogene family 0.317315
PDCD5 programmed cell death 5 0.315135
EFNA3 ephrin-A3 0.314409
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.314046
FASLG Fas ligand (TNF superfamily, member 6) 0.31332
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 0.312595
FZD9 frizzled class receptor 9 0.311507
NOXO1 NADPH oxidase organizer 1 0.311145
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.310783
DSTN destrin (actin depolymerizing factor) 0.310059
SLC26A4 solute carrier family 26 (anion exchanger), member 4 0.309335
RND1 Rho family GTPase 1 0.307167
COQ9 coenzyme Q9 0.306083
ASIC3 acid sensing (proton gated) ion channel 3 0.30464
NEFM neurofilament, medium polypeptide 0.302118
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 0.302118
GRIK1 glutamate receptor, ionotropic, kainate 1 0.301758
BTD biotinidase 0.298165
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.297806
CAPN2 calpain 2, (m/II) large subunit 0.294223
OTOF otoferlin 0.291722
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.291722
CNGB1 cyclic nucleotide gated channel beta 1 0.290295
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.290295
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.289582
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.287803
ADAM22 ADAM metallopeptidase domain 22 0.284962
CHAT choline O-acetyltransferase 0.283899
CLCNKB chloride channel, voltage-sensitive Kb 0.279307
USH1C Usher syndrome 1C (autosomal recessive, severe) 0.277197
EFNB3 ephrin-B3 0.275094
DES desmin 0.272997
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.272649
RET ret proto-oncogene 0.269867
THRB thyroid hormone receptor, beta 0.268828
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.267102
S1PR5 sphingosine-1-phosphate receptor 5 0.265038
ERBB3 erb-b2 receptor tyrosine kinase 3 0.259254
PYCARD PYD and CARD domain containing 0.257237
SIX6 SIX homeobox 6 0.257237
GTF2I general transcription factor IIi 0.255567
NDP Norrie disease (pseudoglioma) 0.252261
PROX1 prospero homeobox 1 0.250627
LHX4 LIM homeobox 4 0.250301
NEFH neurofilament, heavy polypeptide 0.24804
COCH cochlin 0.247399
GJB3 gap junction protein, beta 3, 31kDa 0.246442
POU3F4 POU class 3 homeobox 4 0.245491
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0.244232
EPHA1 EPH receptor A1 0.243294
ADCY2 adenylate cyclase 2 (brain) 0.242054
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.239307
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.239007
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.238108
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.23604
ADAM28 ADAM metallopeptidase domain 28 0.234016
CHD7 chromodomain helicase DNA binding protein 7 0.23176
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.23176
IL1R2 interleukin 1 receptor, type II 0.229839
SNCB synuclein, beta 0.229299
SGK1 serum/glucocorticoid regulated kinase 1 0.227707
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 0.226926
PDZK1IP1 PDZK1 interacting protein 1 0.225395
NID1 nidogen 1 0.224645
ASIC2 acid sensing (proton gated) ion channel 2 0.22246
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.222224
SHH sonic hedgehog 0.221521
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.221061
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.218613
MEF2D myocyte enhancer factor 2D 0.218186
ESR2 estrogen receptor 2 (ER beta) 0.217762
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.215534
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.215341
ACHE acetylcholinesterase (Yt blood group) 0.214576
SIRT4 sirtuin 4 0.214388
MEOX2 mesenchyme homeobox 2 0.214202
FGF10 fibroblast growth factor 10 0.213833
NOS3 nitric oxide synthase 3 (endothelial cell) 0.213471