molsidomine-5426 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the molsidomine-5426 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACAA2 acetyl-CoA acyltransferase 2
ADTRP androgen-dependent TFPI-regulating protein
AKAP8L A kinase (PRKA) anchor protein 8-like
ALOX15 arachidonate 15-lipoxygenase
APLP1 amyloid beta (A4) precursor-like protein 1
ARC activity-regulated cytoskeleton-associated protein
ATXN8OS ATXN8 opposite strand (non-protein coding)
BAIAP3 BAI1-associated protein 3
BCAM basal cell adhesion molecule (Lutheran blood group)
BIN1 bridging integrator 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CD52 CD52 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CFAP45 cilia and flagella associated protein 45
CFHR4 complement factor H-related 4
CLEC4A C-type lectin domain family 4, member A
CNOT3 CCR4-NOT transcription complex, subunit 3
CRMP1 collapsin response mediator protein 1
CTSS cathepsin S
CYBRD1 cytochrome b reductase 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DCTN2 dynactin 2 (p50)
DOCK5 dedicator of cytokinesis 5
DPF1 D4, zinc and double PHD fingers family 1
ESRRA estrogen-related receptor alpha
FAM46C family with sequence similarity 46, member C
FOXG1 forkhead box G1
FRZB frizzled-related protein
FSTL3 follistatin-like 3 (secreted glycoprotein)
GBP1 guanylate binding protein 1, interferon-inducible
GFER growth factor, augmenter of liver regeneration
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GSTA3 glutathione S-transferase alpha 3
HGFAC HGF activator
HIST1H4E histone cluster 1, H4e
HOXA10 homeobox A10
HPX hemopexin
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGKV3-20 immunoglobulin kappa variable 3-20
ING4 inhibitor of growth family, member 4
IRF5 interferon regulatory factor 5
ITM2C integral membrane protein 2C
KDM8 lysine (K)-specific demethylase 8
KLF6 Kruppel-like factor 6
KYNU kynureninase
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LIME1 Lck interacting transmembrane adaptor 1
LOC644450 uncharacterized LOC644450
MAPT microtubule-associated protein tau
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MST1 macrophage stimulating 1
MST1L macrophage stimulating 1-like
NKX3-2 NK3 homeobox 2
NOTCH4 notch 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OASL 2'-5'-oligoadenylate synthetase-like
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PARVA parvin, alpha
PCDHGA11 protocadherin gamma subfamily A, 11
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLSCR4 phospholipid scramblase 4
PON1 paraoxonase 1
PTCRA pre T-cell antigen receptor alpha
RAD52 RAD52 homolog (S. cerevisiae)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RIF1 replication timing regulatory factor 1
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF17 ring finger protein 17
SCG2 secretogranin II
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SH2D3A SH2 domain containing 3A
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC35E2 solute carrier family 35, member E2
SLFN12 schlafen family member 12
SOS2 son of sevenless homolog 2 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPAG8 sperm associated antigen 8
STARD3 StAR-related lipid transfer (START) domain containing 3
STK11 serine/threonine kinase 11
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TBX5 T-box 5
TM4SF4 transmembrane 4 L six family member 4
TMEM212 transmembrane protein 212
TMPRSS11D transmembrane protease, serine 11D
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
VCAN versican
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF287 zinc finger protein 287
ZNF639 zinc finger protein 639
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACTG2 actin, gamma 2, smooth muscle, enteric
AFF4 AF4/FMR2 family, member 4
AKIP1 A kinase (PRKA) interacting protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMC4 armadillo repeat containing 4
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
C2ORF44 chromosome 2 open reading frame 44
CBR4 carbonyl reductase 4
CENPO centromere protein O
CES3 carboxylesterase 3
CIDEC cell death-inducing DFFA-like effector c
CLCN6 chloride channel, voltage-sensitive 6
CLDN15 claudin 15
CLDND1 claudin domain containing 1
CLGN calmegin
CORO2A coronin, actin binding protein, 2A
CORT cortistatin
CRY2 cryptochrome circadian clock 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
DBF4B DBF4 zinc finger B
DMTN dematin actin binding protein
DSCAM Down syndrome cell adhesion molecule
EDAR ectodysplasin A receptor
ERN2 endoplasmic reticulum to nucleus signaling 2
EXO5 exonuclease 5
FGD1 FYVE, RhoGEF and PH domain containing 1
GAB2 GRB2-associated binding protein 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GAMT guanidinoacetate N-methyltransferase
GDAP1 ganglioside induced differentiation associated protein 1
GLB1L galactosidase, beta 1-like
GPR143 G protein-coupled receptor 143
GPR27 G protein-coupled receptor 27
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H3B histone cluster 1, H3b
HIST1H4C histone cluster 1, H4c
IFI6 interferon, alpha-inducible protein 6
IFT140 intraflagellar transport 140
IGFBP6 insulin-like growth factor binding protein 6
IQCG IQ motif containing G
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LMNB1 lamin B1
LRRC20 leucine rich repeat containing 20
LYPLA2P1 lysophospholipase II pseudogene 1
LYRM9 LYR motif containing 9
MANBA mannosidase, beta A, lysosomal
MFAP2 microfibrillar-associated protein 2
MGC12488
MRPS18C mitochondrial ribosomal protein S18C
NAT6 N-acetyltransferase 6 (GCN5-related)
NHEJ1 nonhomologous end-joining factor 1
NIPAL2 NIPA-like domain containing 2
NME5 NME/NM23 family member 5
NOD1 nucleotide-binding oligomerization domain containing 1
NOL10 nucleolar protein 10
NOL12 nucleolar protein 12
NPIPB15 nuclear pore complex interacting protein family, member B15
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PCDHA9 protocadherin alpha 9
PCDHB13 protocadherin beta 13
PDE12 phosphodiesterase 12
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PODNL1 podocan-like 1
PPT2 palmitoyl-protein thioesterase 2
PRICKLE3 prickle homolog 3 (Drosophila)
PSG4 pregnancy specific beta-1-glycoprotein 4
RAB30 RAB30, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
RWDD3 RWD domain containing 3
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SIX1 SIX homeobox 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLN sarcolipin
SPON2 spondin 2, extracellular matrix protein
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRD5A3 steroid 5 alpha-reductase 3
SYBU syntabulin (syntaxin-interacting)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TGFBR3 transforming growth factor, beta receptor III
TH tyrosine hydroxylase
TRIM25 tripartite motif containing 25
TRIM36 tripartite motif containing 36
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
USP27X ubiquitin specific peptidase 27, X-linked
WLS wntless Wnt ligand secretion mediator
ZNF254 zinc finger protein 254
ZNF492 zinc finger protein 492
ZNF767P zinc finger family member 767, pseudogene