mometasone-5116 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the mometasone-5116 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ALDOB aldolase B, fructose-bisphosphate
ALLC allantoicase
AMIGO2 adhesion molecule with Ig-like domain 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF93 chromosome 14 open reading frame 93
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CD7 CD7 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DMBT1 deleted in malignant brain tumors 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
ERO1LB ERO1-like beta (S. cerevisiae)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F5 coagulation factor V (proaccelerin, labile factor)
FAM182B family with sequence similarity 182, member B
FGF22 fibroblast growth factor 22
FILIP1L filamin A interacting protein 1-like
FOSL2 FOS-like antigen 2
FOXO4 forkhead box O4
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
HAND1 heart and neural crest derivatives expressed 1
HCRP1 hepatocellular carcinoma-related HCRP1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOOK1 hook microtubule-tethering protein 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL6 interleukin 6
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JAK3 Janus kinase 3
KLF6 Kruppel-like factor 6
KLHL25 kelch-like family member 25
KRT34 keratin 34, type I
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LEFTY2 left-right determination factor 2
LIPG lipase, endothelial
LPAR4 lysophosphatidic acid receptor 4
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MCL1 myeloid cell leukemia 1
MIER2 mesoderm induction early response 1, family member 2
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MUC7 mucin 7, secreted
NAV2 neuron navigator 2
NNMT nicotinamide N-methyltransferase
NRP2 neuropilin 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCSK6 proprotein convertase subtilisin/kexin type 6
PER1 period circadian clock 1
PLAT plasminogen activator, tissue
PRSS16 protease, serine, 16 (thymus)
PSD4 pleckstrin and Sec7 domain containing 4
PTEN phosphatase and tensin homolog
PVR poliovirus receptor
RARG retinoic acid receptor, gamma
RGS5 regulator of G-protein signaling 5
RNFT1 ring finger protein, transmembrane 1
RUNX1 runt-related transcription factor 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC14L2 SEC14-like 2 (S. cerevisiae)
SIRPB1 signal-regulatory protein beta 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPHK2 sphingosine kinase 2
SQLE squalene epoxidase
STARD5 StAR-related lipid transfer (START) domain containing 5
STC2 stanniocalcin 2
TGFB2 transforming growth factor, beta 2
THBS1 thrombospondin 1
TIMP4 TIMP metallopeptidase inhibitor 4
TJAP1 tight junction associated protein 1 (peripheral)
TLDC1 TBC/LysM-associated domain containing 1
TLR2 toll-like receptor 2
TMEM63A transmembrane protein 63A
TOM1 target of myb1 (chicken)
TRIB3 tribbles pseudokinase 3
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
WIZ widely interspaced zinc finger motifs
ZDHHC8P1 zinc finger, DHHC-type containing 8 pseudogene 1
ZFP36 ZFP36 ring finger protein
ZNF268 zinc finger protein 268

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ANKRD10 ankyrin repeat domain 10
APH1A APH1A gamma secretase subunit
ARHGAP24 Rho GTPase activating protein 24
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARRB2 arrestin, beta 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAK1 BCL2-antagonist/killer 1
BCL9 B-cell CLL/lymphoma 9
BEX4 brain expressed, X-linked 4
BTBD2 BTB (POZ) domain containing 2
C1ORF35 chromosome 1 open reading frame 35
C7ORF69 chromosome 7 open reading frame 69
C8ORF60 chromosome 8 open reading frame 60
CBX7 chromobox homolog 7
CDH7 cadherin 7, type 2
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CENPC centromere protein C
CISH cytokine inducible SH2-containing protein
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPEB1 cytoplasmic polyadenylation element binding protein 1
CSRNP3 cysteine-serine-rich nuclear protein 3
CUL9 cullin 9
DNAL4 dynein, axonemal, light chain 4
DTX4 deltex 4, E3 ubiquitin ligase
ECM1 extracellular matrix protein 1
EPHB6 EPH receptor B6
EVPL envoplakin
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM102A family with sequence similarity 102, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXO2 F-box protein 2
FZD8 frizzled class receptor 8
GPR3 G protein-coupled receptor 3
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GUSBP3 glucuronidase, beta pseudogene 3
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA4 homeobox A4
HOXC4 homeobox C4
IFI6 interferon, alpha-inducible protein 6
IL11RA interleukin 11 receptor, alpha
IL17RA interleukin 17 receptor A
IL1B interleukin 1, beta
INPPL1 inositol polyphosphate phosphatase-like 1
JAM3 junctional adhesion molecule 3
KCTD7 potassium channel tetramerization domain containing 7
LIME1 Lck interacting transmembrane adaptor 1
LOC730101 uncharacterized LOC730101
LPAR6 lysophosphatidic acid receptor 6
LY6G5C lymphocyte antigen 6 complex, locus G5C
MED15 mediator complex subunit 15
MFSD6 major facilitator superfamily domain containing 6
MRPL44 mitochondrial ribosomal protein L44
NDP Norrie disease (pseudoglioma)
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OSR2 odd-skipped related transciption factor 2
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PALMD palmdelphin
PER3 period circadian clock 3
PEX26 peroxisomal biogenesis factor 26
PHACTR4 phosphatase and actin regulator 4
PLAU plasminogen activator, urokinase
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKG2 protein kinase, cGMP-dependent, type II
QSER1 glutamine and serine rich 1
RFWD3 ring finger and WD repeat domain 3
RIN1 Ras and Rab interactor 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPP25 ribonuclease P/MRP 25kDa subunit
S100A3 S100 calcium binding protein A3
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLITRK5 SLIT and NTRK-like family, member 5
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNPH syntaphilin
SOBP sine oculis binding protein homolog (Drosophila)
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SSBP3 single stranded DNA binding protein 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBXAS1 thromboxane A synthase 1 (platelet)
TEP1 telomerase-associated protein 1
TEX40 testis expressed 40
TGS1 trimethylguanosine synthase 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMCC2 transmembrane and coiled-coil domain family 2
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRIM25 tripartite motif containing 25
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
WNT7A wingless-type MMTV integration site family, member 7A
ZNF415 zinc finger protein 415