monastrol-610 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the monastrol-610 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
AGFG2 ArfGAP with FG repeats 2
ANO10 anoctamin 10
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATXN8OS ATXN8 opposite strand (non-protein coding)
BCL3 B-cell CLL/lymphoma 3
BMP8A bone morphogenetic protein 8a
C3ORF52 chromosome 3 open reading frame 52
CALU calumenin
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCS copper chaperone for superoxide dismutase
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CTRC chymotrypsin C (caldecrin)
DAAM1 dishevelled associated activator of morphogenesis 1
DEFA4 defensin, alpha 4, corticostatin
DENND1C DENN/MADD domain containing 1C
DHRS9 dehydrogenase/reductase (SDR family) member 9
DND1 DND microRNA-mediated repression inhibitor 1
EFNB3 ephrin-B3
EGR4 early growth response 4
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8L1 EPS8-like 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM162A family with sequence similarity 162, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FHL3 four and a half LIM domains 3
FLT3 fms-related tyrosine kinase 3
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GLRX glutaredoxin (thioltransferase)
GPR3 G protein-coupled receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHIPL2 HHIP-like 2
HNF4A hepatocyte nuclear factor 4, alpha
IDUA iduronidase, alpha-L-
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL19 interleukin 19
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL1RN interleukin 1 receptor antagonist
ITK IL2-inducible T-cell kinase
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLK13 kallikrein-related peptidase 13
LGALS4 lectin, galactoside-binding, soluble, 4
LIMS2 LIM and senescent cell antigen-like domains 2
LRRC23 leucine rich repeat containing 23
LZTS1 leucine zipper, putative tumor suppressor 1
MAP4 microtubule-associated protein 4
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED28 mediator complex subunit 28
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NADK NAD kinase
NCKIPSD NCK interacting protein with SH3 domain
NCR2 natural cytotoxicity triggering receptor 2
NEBL nebulette
NEMF nuclear export mediator factor
NF1 neurofibromin 1
NOS1 nitric oxide synthase 1 (neuronal)
NPTX1 neuronal pentraxin I
NR4A1 nuclear receptor subfamily 4, group A, member 1
OASL 2'-5'-oligoadenylate synthetase-like
OBSL1 obscurin-like 1
OLFM1 olfactomedin 1
PADI1 peptidyl arginine deiminase, type I
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARM1 prostate androgen-regulated mucin-like protein 1
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PP14571 uncharacterized LOC100130449
PRPH2 peripherin 2 (retinal degeneration, slow)
RCAN1 regulator of calcineurin 1
RGS14 regulator of G-protein signaling 14
RUNX2 runt-related transcription factor 2
SCAMP1 secretory carrier membrane protein 1
SGCE sarcoglycan, epsilon
SGK2 serum/glucocorticoid regulated kinase 2
SIRPA signal-regulatory protein alpha
SMC5 structural maintenance of chromosomes 5
SPDEF SAM pointed domain containing ETS transcription factor
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPRR1B small proline-rich protein 1B
SSX3 synovial sarcoma, X breakpoint 3
STK19 serine/threonine kinase 19
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFA transforming growth factor, alpha
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP53TG1 TP53 target 1 (non-protein coding)
TRA2A transformer 2 alpha homolog (Drosophila)
TRAM2 translocation associated membrane protein 2
TRIB3 tribbles pseudokinase 3
TRIM3 tripartite motif containing 3
TSPYL2 TSPY-like 2
VRK3 vaccinia related kinase 3
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AGBL5 ATP/GTP binding protein-like 5
ALG12 ALG12, alpha-1,6-mannosyltransferase
APIP APAF1 interacting protein
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASTE1 asteroid homolog 1 (Drosophila)
AURKC aurora kinase C
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL9 B-cell CLL/lymphoma 9
CCDC28A coiled-coil domain containing 28A
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CHAF1B chromatin assembly factor 1, subunit B (p60)
CLSTN2 calsyntenin 2
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNPY3 canopy FGF signaling regulator 3
COPZ2 coatomer protein complex, subunit zeta 2
CPTP ceramide-1-phosphate transfer protein
CTNNBIP1 catenin, beta interacting protein 1
CUZD1 CUB and zona pellucida-like domains 1
DCP1A decapping mRNA 1A
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHDDS dehydrodolichyl diphosphate synthase
DRP2 dystrophin related protein 2
DSCAM Down syndrome cell adhesion molecule
EGR3 early growth response 3
EPHA4 EPH receptor A4
FKBPL FK506 binding protein like
FOXC1 forkhead box C1
GDAP2 ganglioside induced differentiation associated protein 2
GMIP GEM interacting protein
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNG3 guanine nucleotide binding protein (G protein), gamma 3
HELLS helicase, lymphoid-specific
HOOK1 hook microtubule-tethering protein 1
HPN hepsin
IGKV1D-13 immunoglobulin kappa variable 1D-13
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
JOSD1 Josephin domain containing 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL28 kelch-like family member 28
KLHL36 kelch-like family member 36
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOXL1 lysyl oxidase-like 1
MAGEF1 melanoma antigen family F1
MALL mal, T-cell differentiation protein-like
MSX1 msh homeobox 1
NARF nuclear prelamin A recognition factor
NAT6 N-acetyltransferase 6 (GCN5-related)
NCK2 NCK adaptor protein 2
NCS1 neuronal calcium sensor 1
NOL6 nucleolar protein 6 (RNA-associated)
NUPL1 nucleoporin like 1
ORC1 origin recognition complex, subunit 1
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PDZD7 PDZ domain containing 7
PFAS phosphoribosylformylglycinamidine synthase
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PISD phosphatidylserine decarboxylase
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PQLC3 PQ loop repeat containing 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RHOF ras homolog family member F (in filopodia)
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMYD5 SMYD family member 5
SNX10 sorting nexin 10
SNX6 sorting nexin 6
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TGM3 transglutaminase 3
THBS3 thrombospondin 3
TMEM51 transmembrane protein 51
TRAF5 TNF receptor-associated factor 5
TRAPPC12 trafficking protein particle complex 12
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN32 tetraspanin 32
TSSC4 tumor suppressing subtransferable candidate 4
TTC4 tetratricopeptide repeat domain 4
UFSP2 UFM1-specific peptidase 2
VIM vimentin
WDR13 WD repeat domain 13
YEATS2 YEATS domain containing 2
ZNF428 zinc finger protein 428
ZNF480 zinc finger protein 480
ZNF580 zinc finger protein 580
ZNF91 zinc finger protein 91