monocrotaline-6771 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the monocrotaline-6771 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ADCY3 adenylate cyclase 3
AIM1L absent in melanoma 1-like
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOM apolipoprotein M
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
C4BPA complement component 4 binding protein, alpha
CA5B carbonic anhydrase VB, mitochondrial
CAMK1 calcium/calmodulin-dependent protein kinase I
CASZ1 castor zinc finger 1
CCNJL cyclin J-like
CFLAR CASP8 and FADD-like apoptosis regulator
CHKB choline kinase beta
COPA coatomer protein complex, subunit alpha
CPA4 carboxypeptidase A4
CTBP2 C-terminal binding protein 2
DICER1 dicer 1, ribonuclease type III
DMPK dystrophia myotonica-protein kinase
DNM3 dynamin 3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DUSP13 dual specificity phosphatase 13
EFNB3 ephrin-B3
EGFL7 EGF-like-domain, multiple 7
EWSR1 EWS RNA-binding protein 1
FABP3 fatty acid binding protein 3, muscle and heart
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FHOD1 formin homology 2 domain containing 1
FLJ11292
FRZB frizzled-related protein
FSCN1 fascin actin-bundling protein 1
GPER1 G protein-coupled estrogen receptor 1
GPR15 G protein-coupled receptor 15
GREB1 growth regulation by estrogen in breast cancer 1
HAP1 huntingtin-associated protein 1
HIPK2 homeodomain interacting protein kinase 2
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IFT27 intraflagellar transport 27
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL6R interleukin 6 receptor
INHBA inhibin, beta A
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA0754 KIAA0754
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAMP3 lysosomal-associated membrane protein 3
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LPCAT4 lysophosphatidylcholine acyltransferase 4
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP4 microtubule-associated protein 4
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MBNL3 muscleblind-like splicing regulator 3
MINK1 misshapen-like kinase 1
MKL1 megakaryoblastic leukemia (translocation) 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP25 matrix metallopeptidase 25
MOB3B MOB kinase activator 3B
MZF1 myeloid zinc finger 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
PCDH7 protocadherin 7
PCDHA9 protocadherin alpha 9
PENK proenkephalin
PEX6 peroxisomal biogenesis factor 6
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIDD1 p53-induced death domain protein 1
PLIN2 perilipin 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RTEL1 regulator of telomere elongation helicase 1
SCN1B sodium channel, voltage gated, type I beta subunit
SERGEF secretion regulating guanine nucleotide exchange factor
SHOX2 short stature homeobox 2
SIGLEC8 sialic acid binding Ig-like lectin 8
SOX2 SRY (sex determining region Y)-box 2
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STK11 serine/threonine kinase 11
STK24 serine/threonine kinase 24
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TIMP3 TIMP metallopeptidase inhibitor 3
TJP3 tight junction protein 3
TLE2 transducin-like enhancer of split 2
TMOD1 tropomodulin 1
TNPO2 transportin 2
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TRPM6 transient receptor potential cation channel, subfamily M, member 6
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VASH2 vasohibin 2
VIM vimentin
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WDR62 WD repeat domain 62
XAB2 XPA binding protein 2
ZBED1 zinc finger, BED-type containing 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF76 zinc finger protein 76
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ABHD17B abhydrolase domain containing 17B
ACSF2 acyl-CoA synthetase family member 2
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD40 ankyrin repeat domain 40
ANXA2P3 annexin A2 pseudogene 3
ARC activity-regulated cytoskeleton-associated protein
ARRB1 arrestin, beta 1
ATAD5 ATPase family, AAA domain containing 5
BPGM 2,3-bisphosphoglycerate mutase
C11ORF30 chromosome 11 open reading frame 30
C17ORF80 chromosome 17 open reading frame 80
C1ORF56 chromosome 1 open reading frame 56
C7ORF43 chromosome 7 open reading frame 43
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CLDN1 claudin 1
CNPY3 canopy FGF signaling regulator 3
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTNNBIP1 catenin, beta interacting protein 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
EXD3 exonuclease 3'-5' domain containing 3
FBXO22 F-box protein 22
FRS2 fibroblast growth factor receptor substrate 2
GAMT guanidinoacetate N-methyltransferase
GATA4 GATA binding protein 4
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRB7 growth factor receptor-bound protein 7
GTF2I general transcription factor IIi
HHLA3 HERV-H LTR-associating 3
HIST1H2AJ histone cluster 1, H2aj
IFI6 interferon, alpha-inducible protein 6
IL17RA interleukin 17 receptor A
IRF1 interferon regulatory factor 1
JMJD4 jumonji domain containing 4
KCTD20 potassium channel tetramerization domain containing 20
KDM8 lysine (K)-specific demethylase 8
KIAA0125 KIAA0125
KIAA0895 KIAA0895
KPTN kaptin (actin binding protein)
KRT86 keratin 86, type II
LINC00115 long intergenic non-protein coding RNA 115
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC730101 uncharacterized LOC730101
LY6D lymphocyte antigen 6 complex, locus D
LYPD1 LY6/PLAUR domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MGC12488
MNX1 motor neuron and pancreas homeobox 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NNAT neuronatin
NUPL2 nucleoporin like 2
NXN nucleoredoxin
P3H1 prolyl 3-hydroxylase 1
PAQR6 progestin and adipoQ receptor family member VI
PCDH12 protocadherin 12
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLIN3 perilipin 3
PLXNA3 plexin A3
POMT2 protein-O-mannosyltransferase 2
PRICKLE3 prickle homolog 3 (Drosophila)
PTTG3P pituitary tumor-transforming 3, pseudogene
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB27B RAB27B, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFTN1 raftlin, lipid raft linker 1
RGS2 regulator of G-protein signaling 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
RPAP2 RNA polymerase II associated protein 2
SAMHD1 SAM domain and HD domain 1
SCAI suppressor of cancer cell invasion
SHARPIN SHANK-associated RH domain interactor
SLC16A6 solute carrier family 16, member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLIT2 slit homolog 2 (Drosophila)
SMR3A submaxillary gland androgen regulated protein 3A
SP1 Sp1 transcription factor
TBX19 T-box 19
THBS3 thrombospondin 3
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TICAM1 toll-like receptor adaptor molecule 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN1 tetraspanin 1
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBQLN4 ubiquilin 4
WDR76 WD repeat domain 76
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF571 zinc finger protein 571
ZNF675 zinc finger protein 675
ZNF747 zinc finger protein 747