moxisylyte-1682 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the moxisylyte-1682 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABHD6 abhydrolase domain containing 6
ACBD4 acyl-CoA binding domain containing 4
AEN apoptosis enhancing nuclease
AHI1 Abelson helper integration site 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARL4C ADP-ribosylation factor-like 4C
ATAT1 alpha tubulin acetyltransferase 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BAIAP2 BAI1-associated protein 2
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL2L2 BCL2-like 2
C11ORF21 chromosome 11 open reading frame 21
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD82 CD82 molecule
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
DCTN1 dynactin 1
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
E2F4 E2F transcription factor 4, p107/p130-binding
EMID1 EMI domain containing 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO31 F-box protein 31
FLOT1 flotillin 1
FNDC3A fibronectin type III domain containing 3A
FOXG1 forkhead box G1
GAS7 growth arrest-specific 7
GJA9 gap junction protein, alpha 9, 59kDa
HDAC5 histone deacetylase 5
HOXC5 homeobox C5
IDS iduronate 2-sulfatase
IFT74 intraflagellar transport 74
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL11 interleukin 11
IL17RA interleukin 17 receptor A
IL1B interleukin 1, beta
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IRS2 insulin receptor substrate 2
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KLHL22 kelch-like family member 22
LIME1 Lck interacting transmembrane adaptor 1
MBNL3 muscleblind-like splicing regulator 3
MCOLN3 mucolipin 3
MLANA melan-A
MMP25 matrix metallopeptidase 25
NCAPH2 non-SMC condensin II complex, subunit H2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK2 NIMA-related kinase 2
NF1 neurofibromin 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFYA nuclear transcription factor Y, alpha
NLRX1 NLR family member X1
PALM paralemmin
PARD6B par-6 family cell polarity regulator beta
PBX2 pre-B-cell leukemia homeobox 2
PCDHB13 protocadherin beta 13
PIDD1 p53-induced death domain protein 1
PKNOX2 PBX/knotted 1 homeobox 2
PLCD1 phospholipase C, delta 1
PMP22 peripheral myelin protein 22
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PTK6 protein tyrosine kinase 6
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTRF polymerase I and transcript release factor
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RANBP3 RAN binding protein 3
RASAL2 RAS protein activator like 2
RPL7 ribosomal protein L7
SCRN3 secernin 3
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SOS2 son of sevenless homolog 2 (Drosophila)
SPATA5L1 spermatogenesis associated 5-like 1
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SRP72 signal recognition particle 72kDa
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
STX7 syntaxin 7
TFDP3 transcription factor Dp family, member 3
TRABD TraB domain containing
TRIM68 tripartite motif containing 68
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VIPR2 vasoactive intestinal peptide receptor 2
WFDC2 WAP four-disulfide core domain 2
WWC2 WW and C2 domain containing 2
YIPF4 Yip1 domain family, member 4
ZDHHC17 zinc finger, DHHC-type containing 17
ZFPL1 zinc finger protein-like 1
ZNF134 zinc finger protein 134
ZNF253 zinc finger protein 253
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACSF2 acyl-CoA synthetase family member 2
ADCY6 adenylate cyclase 6
AMPD2 adenosine monophosphate deaminase 2
ANAPC2 anaphase promoting complex subunit 2
ANKRD40 ankyrin repeat domain 40
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAGE B melanoma antigen
BCL9 B-cell CLL/lymphoma 9
CASZ1 castor zinc finger 1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPJ centromere protein J
CENPQ centromere protein Q
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CIR1 corepressor interacting with RBPJ, 1
CLSPN claspin
CORO1A coronin, actin binding protein, 1A
DDIT3 DNA-damage-inducible transcript 3
DSCAM Down syndrome cell adhesion molecule
ERO1L ERO1-like (S. cerevisiae)
FAAH fatty acid amide hydrolase
FBRS fibrosin
FBXL2 F-box and leucine-rich repeat protein 2
FLT4 fms-related tyrosine kinase 4
FMO4 flavin containing monooxygenase 4
FSD1 fibronectin type III and SPRY domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GBP2 guanylate binding protein 2, interferon-inducible
GLS2 glutaminase 2 (liver, mitochondrial)
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HMOX1 heme oxygenase 1
IDI2-AS1 IDI2 antisense RNA 1
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KLC2 kinesin light chain 2
KRBOX4 KRAB box domain containing 4
LAMB3 laminin, beta 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP1S microtubule-associated protein 1S
MED9 mediator complex subunit 9
MFSD12 major facilitator superfamily domain containing 12
MNX1 motor neuron and pancreas homeobox 1
NCAM2 neural cell adhesion molecule 2
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NEK11 NIMA-related kinase 11
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NPY1R neuropeptide Y receptor Y1
NRSN2 neurensin 2
NT5C 5', 3'-nucleotidase, cytosolic
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PARG poly (ADP-ribose) glycohydrolase
PELI1 pellino E3 ubiquitin protein ligase 1
PER3 period circadian clock 3
PGPEP1 pyroglutamyl-peptidase I
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G10 phospholipase A2, group X
PLAC8 placenta-specific 8
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTBP2 polypyrimidine tract binding protein 2
PTDSS2 phosphatidylserine synthase 2
RAB4B RAB4B, member RAS oncogene family
RARS arginyl-tRNA synthetase
RGS19 regulator of G-protein signaling 19
RIBC2 RIB43A domain with coiled-coils 2
RPAP1 RNA polymerase II associated protein 1
S100A4 S100 calcium binding protein A4
SH2D4A SH2 domain containing 4A
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX12 SRY (sex determining region Y)-box 12
SPIDR scaffolding protein involved in DNA repair
STX5 syntaxin 5
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYT17 synaptotagmin XVII
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TMEM120B transmembrane protein 120B
TMEM62 transmembrane protein 62
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TTC30A tetratricopeptide repeat domain 30A
TUBA4A tubulin, alpha 4a
YEATS2 YEATS domain containing 2
ZNF276 zinc finger protein 276
ZNF32 zinc finger protein 32