moxonidine-4084 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the moxonidine-4084 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRE2 adhesion G protein-coupled receptor E2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDOB aldolase B, fructose-bisphosphate
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOC4 apolipoprotein C-IV
ARHGAP26 Rho GTPase activating protein 26
ARTN artemin
ASCL1 achaete-scute family bHLH transcription factor 1
BAAT bile acid CoA:amino acid N-acyltransferase
BBC3 BCL2 binding component 3
BMP4 bone morphogenetic protein 4
C11ORF16 chromosome 11 open reading frame 16
C2CD2L C2CD2-like
CASR calcium-sensing receptor
CCDC170 coiled-coil domain containing 170
CD6 CD6 molecule
CEP152 centrosomal protein 152kDa
CLEC4M C-type lectin domain family 4, member M
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CPN2 carboxypeptidase N, polypeptide 2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL8 chemokine (C-X-C motif) ligand 8
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDN dendrin
DST dystonin
EDIL3 EGF-like repeats and discoidin I-like domains 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FGF22 fibroblast growth factor 22
FGFR2 fibroblast growth factor receptor 2
FRMD4A FERM domain containing 4A
FUBP1 far upstream element (FUSE) binding protein 1
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GALR3 galanin receptor 3
GNRHR gonadotropin-releasing hormone receptor
GPR161 G protein-coupled receptor 161
GRM8 glutamate receptor, metabotropic 8
GTF2I general transcription factor IIi
HOXD10 homeobox D10
IGHM immunoglobulin heavy constant mu
IGSF6 immunoglobulin superfamily, member 6
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQCC IQ motif containing C
IRF4 interferon regulatory factor 4
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAG1 jagged 1
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIF1C kinesin family member 1C
KLF12 Kruppel-like factor 12
KLK10 kallikrein-related peptidase 10
KMT2A lysine (K)-specific methyltransferase 2A
LAMA2 laminin, alpha 2
LIPG lipase, endothelial
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
METTL7A methyltransferase like 7A
MLANA melan-A
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NEK9 NIMA-related kinase 9
NF1 neurofibromin 1
OPRK1 opioid receptor, kappa 1
PBX2 pre-B-cell leukemia homeobox 2
PGK2 phosphoglycerate kinase 2
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLCH2 phospholipase C, eta 2
PLN phospholamban
PLXDC1 plexin domain containing 1
PMFBP1 polyamine modulated factor 1 binding protein 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBM12B-AS1 RBM12B antisense RNA 1
RDH8 retinol dehydrogenase 8 (all-trans)
RGS6 regulator of G-protein signaling 6
RIF1 replication timing regulatory factor 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPLP2 ribosomal protein, large, P2
RRAD Ras-related associated with diabetes
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SS18 synovial sarcoma translocation, chromosome 18
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SUGP1 SURP and G patch domain containing 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TGFB2 transforming growth factor, beta 2
TNIK TRAF2 and NCK interacting kinase
TNNT3 troponin T type 3 (skeletal, fast)
TP53I11 tumor protein p53 inducible protein 11
TRPC1 transient receptor potential cation channel, subfamily C, member 1
USP22 ubiquitin specific peptidase 22
WIPI2 WD repeat domain, phosphoinositide interacting 2
XCL1 chemokine (C motif) ligand 1
ZNF391 zinc finger protein 391

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ACE angiotensin I converting enzyme
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
AGMAT agmatine ureohydrolase (agmatinase)
ANP32A-IT1 ANP32A intronic transcript 1
APH1B APH1B gamma secretase subunit
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARL15 ADP-ribosylation factor-like 15
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAGE B melanoma antigen
BAHCC1 BAH domain and coiled-coil containing 1
BTC betacellulin
C17ORF70 chromosome 17 open reading frame 70
C1QTNF1 C1q and tumor necrosis factor related protein 1
CCDC85C coiled-coil domain containing 85C
CD82 CD82 molecule
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDIP1 cell death-inducing p53 target 1
CDKL3 cyclin-dependent kinase-like 3
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CNGB3 cyclic nucleotide gated channel beta 3
CNTFR ciliary neurotrophic factor receptor
CPPED1 calcineurin-like phosphoesterase domain containing 1
CUZD1 CUB and zona pellucida-like domains 1
CXORF21 chromosome X open reading frame 21
DENND4A DENN/MADD domain containing 4A
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPYS dihydropyrimidinase
DUSP8 dual specificity phosphatase 8
EFNB1 ephrin-B1
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
EYA3 EYA transcriptional coactivator and phosphatase 3
FBXO31 F-box protein 31
FLJ21369 uncharacterized protein FLJ21369
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GAN gigaxonin
GAS8 growth arrest-specific 8
GLS2 glutaminase 2 (liver, mitochondrial)
GPR1 G protein-coupled receptor 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
GSTCD glutathione S-transferase, C-terminal domain containing
HIST1H3F histone cluster 1, H3f
HOXA4 homeobox A4
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFT140 intraflagellar transport 140
INPPL1 inositol polyphosphate phosphatase-like 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLC2 kinesin light chain 2
KLF1 Kruppel-like factor 1 (erythroid)
KLF3 Kruppel-like factor 3 (basic)
LINC00260 long intergenic non-protein coding RNA 260
LOC100286895 cell division cycle 27 homolog pseudogene
LOC157562 uncharacterized LOC157562
LUM lumican
LY6D lymphocyte antigen 6 complex, locus D
LYPD3 LY6/PLAUR domain containing 3
MMP9 matrix metallopeptidase 9
MTA2 metastasis associated 1 family, member 2
MYLK myosin light chain kinase
NAT6 N-acetyltransferase 6 (GCN5-related)
NGF nerve growth factor (beta polypeptide)
NOD1 nucleotide-binding oligomerization domain containing 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5DC3 5'-nucleotidase domain containing 3
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGA10 protocadherin gamma subfamily A, 10
PPL periplakin
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRR7 proline rich 7 (synaptic)
RAB40A RAB40A, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RFPL3 ret finger protein-like 3
RPH3AL rabphilin 3A-like (without C2 domains)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETD1A SET domain containing 1A
SIRT6 sirtuin 6
SLC16A6 solute carrier family 16, member 6
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLITRK5 SLIT and NTRK-like family, member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMR3A submaxillary gland androgen regulated protein 3A
SSTR4 somatostatin receptor 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBKBP1 TBK1 binding protein 1
THRAP3 thyroid hormone receptor associated protein 3
THRB thyroid hormone receptor, beta
TINAGL1 tubulointerstitial nephritis antigen-like 1
UNC119 unc-119 homolog (C. elegans)
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF253 zinc finger protein 253
ZNF268 zinc finger protein 268
ZNF428 zinc finger protein 428
ZNF549 zinc finger protein 549
ZNF747 zinc finger protein 747
ZNF768 zinc finger protein 768