mre11 complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. (Gene Ontology, GO_0030870)
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Genes

58 proteins co-occuring with the mre11 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 3.43967
RAD50 RAD50 homolog (S. cerevisiae) 3.19836
ATM ATM serine/threonine kinase 2.34001
NBN nibrin 1.95302
EXO1 exonuclease 1 1.39239
MDC1 mediator of DNA-damage checkpoint 1 1.38794
UBA2 ubiquitin-like modifier activating enzyme 2 1.29103
H2AFX H2A histone family, member X 1.26075
ATR ATR serine/threonine kinase 1.0104
TOPBP1 topoisomerase (DNA) II binding protein 1 0.937377
RAD51 RAD51 recombinase 0.925604
NABP2 nucleic acid binding protein 2 0.924666
CHEK1 checkpoint kinase 1 0.893018
BRCA1 breast cancer 1, early onset 0.776841
RBBP8 retinoblastoma binding protein 8 0.725705
RAD17 RAD17 homolog (S. pombe) 0.701304
TP53 tumor protein p53 0.699983
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.683335
SPO11 SPO11 meiotic protein covalently bound to DSB 0.631598
TEX11 testis expressed 11 0.609086
CUL5 cullin 5 0.595173
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.580504
DNA2 DNA replication helicase/nuclease 2 0.552251
SSBP2 single-stranded DNA binding protein 2 0.546472
ELF4 E74-like factor 4 (ets domain transcription factor) 0.516532
EXOG endo/exonuclease (5'-3'), endonuclease G-like 0.513677
WRN Werner syndrome, RecQ helicase-like 0.510826
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.504318
TOP1 topoisomerase (DNA) I 0.484483
LIG4 ligase IV, DNA, ATP-dependent 0.460001
RPA2 replication protein A2, 32kDa 0.456809
SESN1 sestrin 1 0.446465
TP53BP1 tumor protein p53 binding protein 1 0.445672
ATMIN ATM interactor 0.431041
HSPA14 heat shock 70kDa protein 14 0.417685
RAD9A RAD9 homolog A (S. pombe) 0.403637
AICDA activation-induced cytidine deaminase 0.382354
ATRIP ATR interacting protein 0.365095
MTBP MDM2 binding protein 0.323075
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.32195
RAD18 RAD18 E3 ubiquitin protein ligase 0.321575
RECQL5 RecQ protein-like 5 0.318579
RAD52 RAD52 homolog (S. cerevisiae) 0.314839
CUL7 cullin 7 0.298826
CDC25A cell division cycle 25A 0.2719
MED23 mediator complex subunit 23 0.265311
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.242797
IARS isoleucyl-tRNA synthetase 0.242437
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 0.224913
HUS1 HUS1 checkpoint homolog (S. pombe) 0.223143
PCNA proliferating cell nuclear antigen 0.22173
BTG2 BTG family, member 2 0.196339
RPA3 replication protein A3, 14kDa 0.19307
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 0.182422
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.168101
TERF2 telomeric repeat binding factor 2 0.166643
SRSF1 serine/arginine-rich splicing factor 1 0.164089
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.159268